Bim-mediated apoptosis and PD-1/PD-L1 pathway impair reactivity of PD1+/CD127- HCV-specific CD8+ cells targeting the virus in chronic hepatitis C virus infection

26 p.

Detalles Bibliográficos
Autores: Larrubia Marfil, Juan Ramón, Benito Martínez, Selma|||0000-0002-3118-0564, Miquel Plaza, Joaquín, Calvino Fernández, Mirian, Sanz de Villalobos, Eduardo, González Praetorius, Alejandro, Albertos, Sonia, García Garzón, Silvia, Parra Cid, Trinidad
Tipo de recurso: artículo
Fecha de publicación:2011
País:España
Institución:Universidad de Alcalá (UAH)
Repositorio:e_Buah Biblioteca Digital Universidad de Alcalá
Idioma:inglés
OAI Identifier:oai:ebuah.uah.es:10017/59265
Acceso en línea:http://hdl.handle.net/10017/59265
https://dx.doi.org/10.1016/j.cellimm.2011.03.011
Access Level:acceso abierto
Palabra clave:HCV
Viral persistence
PD-1
CD127 PD-L1
z-VAD-fmk
Bim
Chronic hepatitis
Apoptosis
Cytotoxic T lymphocytes
Medicina
Medicine
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spelling Bim-mediated apoptosis and PD-1/PD-L1 pathway impair reactivity of PD1+/CD127- HCV-specific CD8+ cells targeting the virus in chronic hepatitis C virus infectionLarrubia Marfil, Juan RamónBenito Martínez, Selma|||0000-0002-3118-0564Miquel Plaza, JoaquínCalvino Fernández, MirianSanz de Villalobos, EduardoGonzález Praetorius, AlejandroAlbertos, SoniaGarcía Garzón, SilviaParra Cid, TrinidadHCVViral persistencePD-1CD127 PD-L1z-VAD-fmkBimChronic hepatitisApoptosisCytotoxic T lymphocytesMedicinaMedicine26 p.PD-1 molecule promotes anergy and IL-7 receptor (CD127) induces an anti-apoptotic effect on T cells. Correlation between PD-1/CD127 phenotype and hepatitis C virus (HCV)-specific CD8+ cell reactivity in resolved infection (RI) after treatment and persistent HCV-infection (PI) was analysed. Directly ex vivo, PD-1 and CD127 expression on HCV-specific CD8+ cells displayed a positive and negative correlation, respectively with viraemia. Proliferation after stimulation on PD-1/CD127+ cells from RI cases was preserved, while it was impaired on PD-1+/CD127 cells from PI patients. PD1+/CD127+ population was observed in PI, and these maintained expansion ability but they did not target the virus. Frequency of PI cases with HCV-specific CD8+ cell proliferation increased after anti-PD-L1 and anti-apoptotic treatment. Bim expression on HCV-specific CD8+ cells from PI patients was enhanced. In conclusion, during chronic HCV infection non-reactive HCV-specific CD8+ cells targeting the virus are PD-1+/CD127/Bim+ and, blocking apoptosis and PD-1/PD-L1 pathway on them enhances in vitro reactivity.Junta de Comunidades de Castilla-La ManchaFundación de Investigación Médica Mutua MadrileñaInstituto de Salud Carlos IIIAsociación de Hepatología Translacional20112011-01-01journal articlehttp://purl.org/coar/resource_type/c_6501NAhttp://purl.org/coar/version/c_be7fb7dd8ff6fe43info:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10017/59265https://dx.doi.org/10.1016/j.cellimm.2011.03.011reponame:e_Buah Biblioteca Digital Universidad de Alcaláinstname:Universidad de Alcalá (UAH)InglésengJunta de Comunidades de Castilla-La Mancha http://dx.doi.org/10.13039/501100011698 Not available Not availableNot available Not available Not availableNot available Not available Not availableNot available Not available Not availableopen accesshttp://purl.org/coar/access_right/c_abf2Attribution-NonCommercial-NoDerivatives 4.0 Internationalhttp://creativecommons.org/licenses/by-nc-nd/4.0/info:eu-repo/semantics/openAccessoai:ebuah.uah.es:10017/592652026-06-18T11:13:07Z
dc.title.none.fl_str_mv Bim-mediated apoptosis and PD-1/PD-L1 pathway impair reactivity of PD1+/CD127- HCV-specific CD8+ cells targeting the virus in chronic hepatitis C virus infection
title Bim-mediated apoptosis and PD-1/PD-L1 pathway impair reactivity of PD1+/CD127- HCV-specific CD8+ cells targeting the virus in chronic hepatitis C virus infection
spellingShingle Bim-mediated apoptosis and PD-1/PD-L1 pathway impair reactivity of PD1+/CD127- HCV-specific CD8+ cells targeting the virus in chronic hepatitis C virus infection
Larrubia Marfil, Juan Ramón
HCV
Viral persistence
PD-1
CD127 PD-L1
z-VAD-fmk
Bim
Chronic hepatitis
Apoptosis
Cytotoxic T lymphocytes
Medicina
Medicine
title_short Bim-mediated apoptosis and PD-1/PD-L1 pathway impair reactivity of PD1+/CD127- HCV-specific CD8+ cells targeting the virus in chronic hepatitis C virus infection
title_full Bim-mediated apoptosis and PD-1/PD-L1 pathway impair reactivity of PD1+/CD127- HCV-specific CD8+ cells targeting the virus in chronic hepatitis C virus infection
title_fullStr Bim-mediated apoptosis and PD-1/PD-L1 pathway impair reactivity of PD1+/CD127- HCV-specific CD8+ cells targeting the virus in chronic hepatitis C virus infection
title_full_unstemmed Bim-mediated apoptosis and PD-1/PD-L1 pathway impair reactivity of PD1+/CD127- HCV-specific CD8+ cells targeting the virus in chronic hepatitis C virus infection
title_sort Bim-mediated apoptosis and PD-1/PD-L1 pathway impair reactivity of PD1+/CD127- HCV-specific CD8+ cells targeting the virus in chronic hepatitis C virus infection
dc.creator.none.fl_str_mv Larrubia Marfil, Juan Ramón
Benito Martínez, Selma|||0000-0002-3118-0564
Miquel Plaza, Joaquín
Calvino Fernández, Mirian
Sanz de Villalobos, Eduardo
González Praetorius, Alejandro
Albertos, Sonia
García Garzón, Silvia
Parra Cid, Trinidad
author Larrubia Marfil, Juan Ramón
author_facet Larrubia Marfil, Juan Ramón
Benito Martínez, Selma|||0000-0002-3118-0564
Miquel Plaza, Joaquín
Calvino Fernández, Mirian
Sanz de Villalobos, Eduardo
González Praetorius, Alejandro
Albertos, Sonia
García Garzón, Silvia
Parra Cid, Trinidad
author_role author
author2 Benito Martínez, Selma|||0000-0002-3118-0564
Miquel Plaza, Joaquín
Calvino Fernández, Mirian
Sanz de Villalobos, Eduardo
González Praetorius, Alejandro
Albertos, Sonia
García Garzón, Silvia
Parra Cid, Trinidad
author2_role author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv HCV
Viral persistence
PD-1
CD127 PD-L1
z-VAD-fmk
Bim
Chronic hepatitis
Apoptosis
Cytotoxic T lymphocytes
Medicina
Medicine
topic HCV
Viral persistence
PD-1
CD127 PD-L1
z-VAD-fmk
Bim
Chronic hepatitis
Apoptosis
Cytotoxic T lymphocytes
Medicina
Medicine
description 26 p.
publishDate 2011
dc.date.none.fl_str_mv 2011
2011-01-01
dc.type.none.fl_str_mv journal article
http://purl.org/coar/resource_type/c_6501
NA
http://purl.org/coar/version/c_be7fb7dd8ff6fe43
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv http://hdl.handle.net/10017/59265
https://dx.doi.org/10.1016/j.cellimm.2011.03.011
url http://hdl.handle.net/10017/59265
https://dx.doi.org/10.1016/j.cellimm.2011.03.011
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.relation.none.fl_str_mv Junta de Comunidades de Castilla-La Mancha http://dx.doi.org/10.13039/501100011698 Not available Not available
Not available Not available Not available
Not available Not available Not available
Not available Not available Not available
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
Attribution-NonCommercial-NoDerivatives 4.0 International
http://creativecommons.org/licenses/by-nc-nd/4.0/
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
Attribution-NonCommercial-NoDerivatives 4.0 International
http://creativecommons.org/licenses/by-nc-nd/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv reponame:e_Buah Biblioteca Digital Universidad de Alcalá
instname:Universidad de Alcalá (UAH)
instname_str Universidad de Alcalá (UAH)
reponame_str e_Buah Biblioteca Digital Universidad de Alcalá
collection e_Buah Biblioteca Digital Universidad de Alcalá
repository.name.fl_str_mv
repository.mail.fl_str_mv
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