Brain network functional connectivity changes in patients with anterior knee pain: a resting-state fMRI exploratory study

BackgroundThis study investigates the functional brain connectivity in patients with anterior knee pain (AKP). While biomechanical models are frequently employed to investigate AKP, it is important to recognize that pain can manifest even in the absence of structural abnormalities. Leveraging the ca...

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Autores: Sanchis-Alfonso, V, Beser-Robles, M, Ten-Esteve, A, Ramírez-Fuentes, C, Alberich-Bayarri, A, Espert, R, García-Larrea, L, Martí-Bonmatí, L
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2023
País:España
Institución:Fundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunitat Valenciana (FISABIO)
Repositorio:r-FISABIO. Repositorio Institucional de Producción Científica
OAI Identifier:oai:fisabio.fundanetsuite.com:p16654
Acceso en línea:https://fisabio.portalinvestigacion.com/publicaciones/16654
Access Level:acceso abierto
Palabra clave:Chronic pain
Brain
Catastrophization
Knee joint
Magnetic resonance imaging
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spelling Brain network functional connectivity changes in patients with anterior knee pain: a resting-state fMRI exploratory studySanchis-Alfonso, VBeser-Robles, MTen-Esteve, ARamírez-Fuentes, CAlberich-Bayarri, AEspert, RGarcía-Larrea, LMartí-Bonmatí, LChronic painBrainCatastrophizationKnee jointMagnetic resonance imagingBackgroundThis study investigates the functional brain connectivity in patients with anterior knee pain (AKP). While biomechanical models are frequently employed to investigate AKP, it is important to recognize that pain can manifest even in the absence of structural abnormalities. Leveraging the capabilities of functional magnetic resonance imaging (fMRI), this research aims to investigate the brain mechanisms present in AKP patients.MethodsForty-five female subjects (24 AKP patients, 21 controls) underwent resting-state fMRI and T1-weighted structural MRI. Functional brain connectivity patterns were analyzed, focusing on pain network areas, and the influence of catastrophizing thoughts was evaluated.ResultsComparing patients and controls, several findings emerged. First, patients with AKP exhibited increased correlation between the right supplementary motor area and cerebellum I, as well as decreased correlation between the right insula and the left rostral prefrontal cortex and superior frontal gyrus. Second, in AKP patients with catastrophizing thoughts, there was increased correlation of the left lateral parietal cortex with two regions of the right cerebellum (II and VII) and the right pallidum, and decreased correlation between the left medial frontal gyrus and the right thalamus. Furthermore, the correlation between these regions showed promising results for discriminating AKP patients from controls, achieving a cross-validation accuracy of 80.5%.ConclusionsResting-state fMRI revealed correlation differences in AKP patients compared to controls and based on catastrophizing thoughts levels. These findings shed light on neural correlates of chronic pain in AKP, suggesting that functional brain connectivity alterations may be linked to pain experience in this population.Relevance statementEtiopathogenesis of pain in anterior knee pain patients might not be limited to the knee, but also to underlying alterations in the central nervous system: cortical changes might lead a perpetuation of pain.Key points center dot Anterior knee pain patients exhibit distinct functional brain connectivity compared to controls, and among catastrophizing subgroups.center dot Resting-state fMRI reveals potential for discriminating anterior knee pain patients with 80.5% accuracy.center dot Functional brain connectivity differences improve understanding of pain pathogenesis and objective anterior knee pain identification.Key points center dot Anterior knee pain patients exhibit distinct functional brain connectivity compared to controls, and among catastrophizing subgroups.center dot Resting-state fMRI reveals potential for discriminating anterior knee pain patients with 80.5% accuracy.center dot Functional brain connectivity differences improve understanding of pain pathogenesis and objective anterior knee pain identification.Key points center dot Anterior knee pain patients exhibit distinct functional brain connectivity compared to controls, and among catastrophizing subgroups.center dot Resting-state fMRI reveals potential for discriminating anterior knee pain patients with 80.5% accuracy.center dot Functional brain connectivity differences improve understanding of pain pathogenesis and objective anterior knee pain identification.SPRINGER WIEN2023info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttps://fisabio.portalinvestigacion.com/publicaciones/16654European Radiology ExperimentalISSN: 25099280reponame:r-FISABIO. Repositorio Institucional de Producción Científicainstname:Fundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunitat Valenciana (FISABIO)Inglésinfo:eu-repo/semantics/openAccessoai:fisabio.fundanetsuite.com:p166542026-06-11T12:45:17Z
dc.title.none.fl_str_mv Brain network functional connectivity changes in patients with anterior knee pain: a resting-state fMRI exploratory study
title Brain network functional connectivity changes in patients with anterior knee pain: a resting-state fMRI exploratory study
spellingShingle Brain network functional connectivity changes in patients with anterior knee pain: a resting-state fMRI exploratory study
Sanchis-Alfonso, V
Chronic pain
Brain
Catastrophization
Knee joint
Magnetic resonance imaging
title_short Brain network functional connectivity changes in patients with anterior knee pain: a resting-state fMRI exploratory study
title_full Brain network functional connectivity changes in patients with anterior knee pain: a resting-state fMRI exploratory study
title_fullStr Brain network functional connectivity changes in patients with anterior knee pain: a resting-state fMRI exploratory study
title_full_unstemmed Brain network functional connectivity changes in patients with anterior knee pain: a resting-state fMRI exploratory study
title_sort Brain network functional connectivity changes in patients with anterior knee pain: a resting-state fMRI exploratory study
dc.creator.none.fl_str_mv Sanchis-Alfonso, V
Beser-Robles, M
Ten-Esteve, A
Ramírez-Fuentes, C
Alberich-Bayarri, A
Espert, R
García-Larrea, L
Martí-Bonmatí, L
author Sanchis-Alfonso, V
author_facet Sanchis-Alfonso, V
Beser-Robles, M
Ten-Esteve, A
Ramírez-Fuentes, C
Alberich-Bayarri, A
Espert, R
García-Larrea, L
Martí-Bonmatí, L
author_role author
author2 Beser-Robles, M
Ten-Esteve, A
Ramírez-Fuentes, C
Alberich-Bayarri, A
Espert, R
García-Larrea, L
Martí-Bonmatí, L
author2_role author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Chronic pain
Brain
Catastrophization
Knee joint
Magnetic resonance imaging
topic Chronic pain
Brain
Catastrophization
Knee joint
Magnetic resonance imaging
description BackgroundThis study investigates the functional brain connectivity in patients with anterior knee pain (AKP). While biomechanical models are frequently employed to investigate AKP, it is important to recognize that pain can manifest even in the absence of structural abnormalities. Leveraging the capabilities of functional magnetic resonance imaging (fMRI), this research aims to investigate the brain mechanisms present in AKP patients.MethodsForty-five female subjects (24 AKP patients, 21 controls) underwent resting-state fMRI and T1-weighted structural MRI. Functional brain connectivity patterns were analyzed, focusing on pain network areas, and the influence of catastrophizing thoughts was evaluated.ResultsComparing patients and controls, several findings emerged. First, patients with AKP exhibited increased correlation between the right supplementary motor area and cerebellum I, as well as decreased correlation between the right insula and the left rostral prefrontal cortex and superior frontal gyrus. Second, in AKP patients with catastrophizing thoughts, there was increased correlation of the left lateral parietal cortex with two regions of the right cerebellum (II and VII) and the right pallidum, and decreased correlation between the left medial frontal gyrus and the right thalamus. Furthermore, the correlation between these regions showed promising results for discriminating AKP patients from controls, achieving a cross-validation accuracy of 80.5%.ConclusionsResting-state fMRI revealed correlation differences in AKP patients compared to controls and based on catastrophizing thoughts levels. These findings shed light on neural correlates of chronic pain in AKP, suggesting that functional brain connectivity alterations may be linked to pain experience in this population.Relevance statementEtiopathogenesis of pain in anterior knee pain patients might not be limited to the knee, but also to underlying alterations in the central nervous system: cortical changes might lead a perpetuation of pain.Key points center dot Anterior knee pain patients exhibit distinct functional brain connectivity compared to controls, and among catastrophizing subgroups.center dot Resting-state fMRI reveals potential for discriminating anterior knee pain patients with 80.5% accuracy.center dot Functional brain connectivity differences improve understanding of pain pathogenesis and objective anterior knee pain identification.Key points center dot Anterior knee pain patients exhibit distinct functional brain connectivity compared to controls, and among catastrophizing subgroups.center dot Resting-state fMRI reveals potential for discriminating anterior knee pain patients with 80.5% accuracy.center dot Functional brain connectivity differences improve understanding of pain pathogenesis and objective anterior knee pain identification.Key points center dot Anterior knee pain patients exhibit distinct functional brain connectivity compared to controls, and among catastrophizing subgroups.center dot Resting-state fMRI reveals potential for discriminating anterior knee pain patients with 80.5% accuracy.center dot Functional brain connectivity differences improve understanding of pain pathogenesis and objective anterior knee pain identification.
publishDate 2023
dc.date.none.fl_str_mv 2023
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://fisabio.portalinvestigacion.com/publicaciones/16654
url https://fisabio.portalinvestigacion.com/publicaciones/16654
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv SPRINGER WIEN
publisher.none.fl_str_mv SPRINGER WIEN
dc.source.none.fl_str_mv European Radiology Experimental
ISSN: 25099280
reponame:r-FISABIO. Repositorio Institucional de Producción Científica
instname:Fundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunitat Valenciana (FISABIO)
instname_str Fundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunitat Valenciana (FISABIO)
reponame_str r-FISABIO. Repositorio Institucional de Producción Científica
collection r-FISABIO. Repositorio Institucional de Producción Científica
repository.name.fl_str_mv
repository.mail.fl_str_mv
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