Hyaluronic acid levels predict risk of hepatic encephalopathy and liver-related death in HIV/viral hepatitis coinfected patients

Background: Whereas it is well established that various soluble biomarkers can predict level of liver fibrosis, their ability to predict liver-related clinical outcomes is less clearly established, in particular among HIV/viral hepatitis co-infected persons. We investigated plasma hyaluronic acid�...

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Autores: Peters, Lars, Mocroft, Amanda, Soriano, Vincent, Rockstroh, Jürgen Kurt, Rauch, Andri, Karlsson, Anders, Knysz, Brygida, Pradier, Christian, Zilmer, Kai, Lundgren, Jens D., Gatell, José M., Miró Meda, José M. (José María), 1956-, EuroSIDA Study Group
Tipo de documento: artigo
Estado:Versão publicada
Data de publicação:2013
País:España
Recursos:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Repositório:Recercat. Dipósit de la Recerca de Catalunya
OAI Identifier:oai:recercat.cat:2445/147923
Acesso em linha:https://hdl.handle.net/2445/147923
Access Level:Acceso aberto
Palavra-chave:VIH (Virus)
Hepatitis vírica
HIV (Viruses)
Viral hepatitis
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spelling Hyaluronic acid levels predict risk of hepatic encephalopathy and liver-related death in HIV/viral hepatitis coinfected patientsPeters, LarsMocroft, AmandaSoriano, VincentRockstroh, Jürgen KurtRauch, AndriKarlsson, AndersKnysz, BrygidaPradier, ChristianZilmer, KaiLundgren, Jens D.Gatell, José M.Miró Meda, José M. (José María), 1956-EuroSIDA Study GroupVIH (Virus)Hepatitis víricaHIV (Viruses)Viral hepatitisBackground: Whereas it is well established that various soluble biomarkers can predict level of liver fibrosis, their ability to predict liver-related clinical outcomes is less clearly established, in particular among HIV/viral hepatitis co-infected persons. We investigated plasma hyaluronic acid's (HA) ability to predict risk of liver-related events (LRE; hepatic coma or liver-related death) in the EuroSIDA study. Methods: Patients included were positive for anti-HCV and/or HBsAg with at least one available plasma sample. The earliest collected plasma sample was tested for HA (normal range 0-75 ng/mL) and levels were associated with risk of LRE. Change in HA per year of follow-up was estimated after measuring HA levels in latest sample before the LRE for those experiencing this outcome (cases) and in a random selection of one sixth of the remaining patients (controls). Results: During a median of 8.2 years of follow-up, 84/1252 (6.7%) patients developed a LRE. Baseline median (IQR) HA in those without and with a LRE was 31.8 (17.2-62.6) and 221.6 ng/mL (74.9-611.3), respectively (p,0.0001). After adjustment, HA levels predicted risk of contracting a LRE; incidence rate ratios for HA levels 75-250 or $250 vs. ,75 ng/mL were 5.22 (95% CI 2.86-9.26, p,0.0007) and 28.22 (95% CI 14.95-46.00, p,0.0001), respectively. Median HA levels increased substantially prior to developing a LRE (107.6 ng/mL, IQR 0.8 to 251.1), but remained stable for controls (1.0 ng/mL, IQR -5.1 to 8.2), (p,0.0001 comparing cases and controls), and greater increases predicted risk of a LRE in adjusted models (p,0.001). Conclusions: An elevated level of plasma HA, particularly if the level further increases over time, substantially increases the risk of contracting LRE over the next five years. HA is an inexpensive, standardized and non-invasive supplement to other methods aimed at identifying HIV/viral hepatitis co-infected patients at risk of hepatic complications.Public Library of Science (PLoS)2020202020132020info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersion10 p.application/pdfapplication/pdfhttps://hdl.handle.net/2445/147923Articles publicats en revistes (Medicina)reponame:Recercat. Dipósit de la Recerca de Catalunyainstname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)InglésReproducció del document publicat a: https://doi.org/10.1371/journal.pone.0064283PLoS One, 2013, vol. 8, num. 5, p. e64283https://doi.org/10.1371/journal.pone.0064283info:eu-repo/grantAgreement/EC/FP7/260694cc-by (c) Peters, Lars et al., 2013http://creativecommons.org/licenses/by/3.0/esinfo:eu-repo/semantics/openAccessoai:recercat.cat:2445/1479232026-05-29T05:05:01Z
dc.title.none.fl_str_mv Hyaluronic acid levels predict risk of hepatic encephalopathy and liver-related death in HIV/viral hepatitis coinfected patients
title Hyaluronic acid levels predict risk of hepatic encephalopathy and liver-related death in HIV/viral hepatitis coinfected patients
spellingShingle Hyaluronic acid levels predict risk of hepatic encephalopathy and liver-related death in HIV/viral hepatitis coinfected patients
Peters, Lars
VIH (Virus)
Hepatitis vírica
HIV (Viruses)
Viral hepatitis
title_short Hyaluronic acid levels predict risk of hepatic encephalopathy and liver-related death in HIV/viral hepatitis coinfected patients
title_full Hyaluronic acid levels predict risk of hepatic encephalopathy and liver-related death in HIV/viral hepatitis coinfected patients
title_fullStr Hyaluronic acid levels predict risk of hepatic encephalopathy and liver-related death in HIV/viral hepatitis coinfected patients
title_full_unstemmed Hyaluronic acid levels predict risk of hepatic encephalopathy and liver-related death in HIV/viral hepatitis coinfected patients
title_sort Hyaluronic acid levels predict risk of hepatic encephalopathy and liver-related death in HIV/viral hepatitis coinfected patients
dc.creator.none.fl_str_mv Peters, Lars
Mocroft, Amanda
Soriano, Vincent
Rockstroh, Jürgen Kurt
Rauch, Andri
Karlsson, Anders
Knysz, Brygida
Pradier, Christian
Zilmer, Kai
Lundgren, Jens D.
Gatell, José M.
Miró Meda, José M. (José María), 1956-
EuroSIDA Study Group
author Peters, Lars
author_facet Peters, Lars
Mocroft, Amanda
Soriano, Vincent
Rockstroh, Jürgen Kurt
Rauch, Andri
Karlsson, Anders
Knysz, Brygida
Pradier, Christian
Zilmer, Kai
Lundgren, Jens D.
Gatell, José M.
Miró Meda, José M. (José María), 1956-
EuroSIDA Study Group
author_role author
author2 Mocroft, Amanda
Soriano, Vincent
Rockstroh, Jürgen Kurt
Rauch, Andri
Karlsson, Anders
Knysz, Brygida
Pradier, Christian
Zilmer, Kai
Lundgren, Jens D.
Gatell, José M.
Miró Meda, José M. (José María), 1956-
EuroSIDA Study Group
author2_role author
author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv VIH (Virus)
Hepatitis vírica
HIV (Viruses)
Viral hepatitis
topic VIH (Virus)
Hepatitis vírica
HIV (Viruses)
Viral hepatitis
description Background: Whereas it is well established that various soluble biomarkers can predict level of liver fibrosis, their ability to predict liver-related clinical outcomes is less clearly established, in particular among HIV/viral hepatitis co-infected persons. We investigated plasma hyaluronic acid's (HA) ability to predict risk of liver-related events (LRE; hepatic coma or liver-related death) in the EuroSIDA study. Methods: Patients included were positive for anti-HCV and/or HBsAg with at least one available plasma sample. The earliest collected plasma sample was tested for HA (normal range 0-75 ng/mL) and levels were associated with risk of LRE. Change in HA per year of follow-up was estimated after measuring HA levels in latest sample before the LRE for those experiencing this outcome (cases) and in a random selection of one sixth of the remaining patients (controls). Results: During a median of 8.2 years of follow-up, 84/1252 (6.7%) patients developed a LRE. Baseline median (IQR) HA in those without and with a LRE was 31.8 (17.2-62.6) and 221.6 ng/mL (74.9-611.3), respectively (p,0.0001). After adjustment, HA levels predicted risk of contracting a LRE; incidence rate ratios for HA levels 75-250 or $250 vs. ,75 ng/mL were 5.22 (95% CI 2.86-9.26, p,0.0007) and 28.22 (95% CI 14.95-46.00, p,0.0001), respectively. Median HA levels increased substantially prior to developing a LRE (107.6 ng/mL, IQR 0.8 to 251.1), but remained stable for controls (1.0 ng/mL, IQR -5.1 to 8.2), (p,0.0001 comparing cases and controls), and greater increases predicted risk of a LRE in adjusted models (p,0.001). Conclusions: An elevated level of plasma HA, particularly if the level further increases over time, substantially increases the risk of contracting LRE over the next five years. HA is an inexpensive, standardized and non-invasive supplement to other methods aimed at identifying HIV/viral hepatitis co-infected patients at risk of hepatic complications.
publishDate 2013
dc.date.none.fl_str_mv 2013
2020
2020
2020
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/2445/147923
url https://hdl.handle.net/2445/147923
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Reproducció del document publicat a: https://doi.org/10.1371/journal.pone.0064283
PLoS One, 2013, vol. 8, num. 5, p. e64283
https://doi.org/10.1371/journal.pone.0064283
info:eu-repo/grantAgreement/EC/FP7/260694
dc.rights.none.fl_str_mv cc-by (c) Peters, Lars et al., 2013
http://creativecommons.org/licenses/by/3.0/es
info:eu-repo/semantics/openAccess
rights_invalid_str_mv cc-by (c) Peters, Lars et al., 2013
http://creativecommons.org/licenses/by/3.0/es
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 10 p.
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Public Library of Science (PLoS)
publisher.none.fl_str_mv Public Library of Science (PLoS)
dc.source.none.fl_str_mv Articles publicats en revistes (Medicina)
reponame:Recercat. Dipósit de la Recerca de Catalunya
instname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
instname_str Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
reponame_str Recercat. Dipósit de la Recerca de Catalunya
collection Recercat. Dipósit de la Recerca de Catalunya
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15.812429

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