A treelet transform analysis to relate nutrient patterns to the risk of hormonal receptor-defined breast cancer in the European Prospective Investigation into Cancer and Nutrition (EPIC)

Objective: Pattern analysis has emerged as a tool to depict the role of multiple nutrients/foods in relation to health outcomes. The present study aimed at extracting nutrient patterns with respect to breast cancer (BC) aetiology. Design: Nutrient patterns were derived with treelet transform (TT) an...

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Detalles Bibliográficos
Autores: Assi, Nada, Moskal, Aurelie, Slimani, Nadia, Viallon, Vivian, Chajès, Véronique, Freisling, Heinz, Monni, Stefano, Knüppel, Sven, Förster, Jana, Weiderpass, Elisabete, Luján Barroso, Leila, Amiano, Pilar, Ardanaz, Eva, Molina Montes, Esther, Salmerón, Diego, Quirós, José Ramón, Olsen, Anja, Tjønneland, Anne, Dahm, Christina C., Overvad, Kim, Dossus, Laure, Fournier, Agnès, Baglietto, Laura, Fortner, Renée T., Kaaks, Rudolf, Trichopoulou, Antonia, Bamia, Christina, Orfanos, Philippos, Santucci de Magistris, Maria, Masala, Giovanna, Agnoli, Claudia, Ricceri, Fulvio, Tumino, Rosario, Bueno de Mesquita, H. Bas, Bakker, Marije F., Peeters, Petra H. M., Skeie, Guri, Braaten, Tonje, Winkvist, Anna, Johansson, Ingegerd
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2016
País:España
Institución:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Repositorio:Recercat. Dipósit de la Recerca de Catalunya
OAI Identifier:oai:recercat.cat:2445/160098
Acceso en línea:https://hdl.handle.net/2445/160098
Access Level:acceso abierto
Palabra clave:Nutrició
Càncer
Nutrition
Cancer
Descripción
Sumario:Objective: Pattern analysis has emerged as a tool to depict the role of multiple nutrients/foods in relation to health outcomes. The present study aimed at extracting nutrient patterns with respect to breast cancer (BC) aetiology. Design: Nutrient patterns were derived with treelet transform (TT) and related to BC risk. TT was applied to twenty-three log-transformed nutrient densities from dietary questionnaires. Hazard ratios (HR) and 95 % confidence intervals computed using Cox proportional hazards models quantified the association between quintiles of nutrient pattern scores and risk of overall BC, and by hormonal receptor and menopausal status. Principal component analysis was applied for comparison. Setting: The European Prospective Investigation into Cancer and Nutrition (EPIC). Subjects: Women (n 334 850) from the EPIC study. Results: The first TT component (TC1) highlighted a pattern rich in nutrients found in animal foods loading on cholesterol, protein, retinol, vitamins B12 and D, while the second TT component (TC2) reflected a diet rich in β-carotene, riboflavin, thiamin, vitamins C and B6, fibre, Fe, Ca, K, Mg, P and folate. While TC1 was not associated with BC risk, TC2 was inversely associated with BC risk overall (HRQ5 v. Q1=0·89, 95 % CI 0·83, 0·95, Ptrend<0·01) and showed a significantly lower risk in oestrogen receptor-positive (HRQ5 v. Q1=0·89, 95 % CI 0·81, 0·98, Ptrend=0·02) and progesterone receptor-positive tumours (HRQ5 v. Q1=0·87, 95 % CI 0·77, 0·98, Ptrend<0·01). Conclusions: TT produces readily interpretable sparse components explaining similar amounts of variation as principal component analysis. Our results suggest that participants with a nutrient pattern high in micronutrients found in vegetables, fruits and cereals had a lower risk of BC.

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