SN-38-loaded nanofiber matrices for local control of pediatric solid tumors after subtotal resection surgery

Monterrubio, Carles; Pascual Pasto, Guillem; Cano Casas, Francesc|||0000-0002-4920-2194; Vilà Ubach, Mònica; Manzanares Quintela, Alejandro; Schaiqueviche, Paula; Tornero García, José Antonio|||0000-0001-9479-825X; Sosnik, alejandro; Mora Graupera, Jaume; Montero Carcaboso, Ángel

SN-38-loaded nanofiber matrices for local control of pediatric solid tumors after subtotal resection surgery

In addition to surgery, local tumor control in pediatric oncology requires new treatments as an alternative to radiotherapy. SN-38 is an anticancer drug with proved activity against several pediatric solid tumors including neuroblastoma, rhabdomyosarcoma and Ewing sarcoma. Taking advantage of the ex...

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Detalles Bibliográficos
Autores:	Monterrubio, Carles, Pascual Pasto, Guillem, Cano Casas, Francesc\|\|\|0000-0002-4920-2194, Vilà Ubach, Mònica, Manzanares Quintela, Alejandro, Schaiqueviche, Paula, Tornero García, José Antonio\|\|\|0000-0001-9479-825X, Sosnik, alejandro, Mora Graupera, Jaume, Montero Carcaboso, Ángel
Tipo de recurso:	artículo
Fecha de publicación:	2015
País:	España
Institución:	Universitat Politècnica de Catalunya (UPC)
Repositorio:	UPCommons. Portal del coneixement obert de la UPC
Idioma:	inglés
OAI Identifier:	oai:upcommons.upc.edu:2117/81791
Acceso en línea:	https://hdl.handle.net/2117/81791 https://dx.doi.org/10.1016/j.biomaterials.2015.11.055
Access Level:	acceso abierto
Palabra clave:	Nanofibers Chemotherapy Tumors in children--Chemotherapy Pharmacokinetics Microdialysis--methods Local chemotherapy delivery SN-38 Poly(lactic acid) electrospun nanofibers Pediatric solid tumor Microdialysis Nanofibres Quimioteràpia Farmacocinètica Tumors -- Tractament Àrees temàtiques de la UPC::Enginyeria tèxtil::Teixits::Teixits mèdics Àrees temàtiques de la UPC::Ciències de la salut::Medicina

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spelling	SN-38-loaded nanofiber matrices for local control of pediatric solid tumors after subtotal resection surgeryMonterrubio, CarlesPascual Pasto, GuillemCano Casas, Francesc\|\|\|0000-0002-4920-2194Vilà Ubach, MònicaManzanares Quintela, AlejandroSchaiqueviche, PaulaTornero García, José Antonio\|\|\|0000-0001-9479-825XSosnik, alejandroMora Graupera, JaumeMontero Carcaboso, ÁngelNanofibersChemotherapyTumors in children--ChemotherapyPharmacokineticsMicrodialysis--methodsLocal chemotherapy deliverySN-38Poly(lactic acid) electrospun nanofibersPediatric solid tumorPharmacokineticsMicrodialysisNanofibresQuimioteràpiaFarmacocinèticaTumors -- TractamentÀrees temàtiques de la UPC::Enginyeria tèxtil::Teixits::Teixits mèdicsÀrees temàtiques de la UPC::Ciències de la salut::MedicinaIn addition to surgery, local tumor control in pediatric oncology requires new treatments as an alternative to radiotherapy. SN-38 is an anticancer drug with proved activity against several pediatric solid tumors including neuroblastoma, rhabdomyosarcoma and Ewing sarcoma. Taking advantage of the extremely low aqueous solubility of SN-38, we have developed a novel drug delivery system (DDS) consisting of matrices made of poly(lactic acid) electrospun polymer nanofibers loaded with SN-38 microcrystals for local release in difficult-to-treat pediatric solid tumors. To model the clinical scenario, we conducted extensive preclinical experiments to characterize the biodistribution of the released SN-38 using microdialysis sampling in vivo. We observed that the drug achieves high concentrations in the virtual space of the surgical bed and penetrates a maximum distance of 2 mm within the tumor bulk. Subsequently, we developed a model of subtotal tumor resection in clinically relevant pediatric patient-derived xenografts and used such models to provide evidence of the activity of the SN-38 DDS to inhibit tumor regrowth. We propose that this novel DDS could represent a potential future strategy to avoid harmful radiation therapy as a primary tumor control together with surgeryIn addition to surgery, local tumor control in pediatric oncology requires new treatments as an alternative to radiotherapy. SN-38 is an anticancer drug with proved activity against several pediatric solid tumors including neuroblastoma, rhabdomyosarcoma and Ewing sarcoma. Taking advantage of the extremely low aqueous solubility of SN-38, we have developed a novel drug delivery system (DDS) consisting of matrices made of poly(lactic acid) electrospun polymer nanofibers loaded with SN-38 microcrystals for local release in difficult-to-treat pediatric solid tumors. To model the clinical scenario, we conducted extensive preclinical experiments to characterize the biodistribution of the released SN-38 using microdialysis sampling in vivo. We observed that the drug achieves high concentrations in the virtual space of the surgical bed and penetrates a maximum distance of 2 mm within the tumor bulk. Subsequently, we developed a model of subtotal tumor resection in clinically relevant pediatric patient-derived xenografts and used such models to provide evidence of the activity of the SN-38 DDS to inhibit tumor regrowth. We propose that this novel DDS could represent a potential future strategy to avoid harmful radiation therapy as a primary tumor control together with surgery20152015-12-0220162016-01-21journal articlehttp://purl.org/coar/resource_type/c_6501AMhttp://purl.org/coar/version/c_ab4af688f83e57aainfo:eu-repo/semantics/articleapplication/pdfhttps://hdl.handle.net/2117/81791https://dx.doi.org/10.1016/j.biomaterials.2015.11.055reponame:UPCommons. Portal del coneixement obert de la UPCinstname:Universitat Politècnica de Catalunya (UPC)Inglésengopen accesshttp://purl.org/coar/access_right/c_abf2info:eu-repo/semantics/openAccessoai:upcommons.upc.edu:2117/817912026-05-27T15:37:01Z
dc.title.none.fl_str_mv	SN-38-loaded nanofiber matrices for local control of pediatric solid tumors after subtotal resection surgery
title	SN-38-loaded nanofiber matrices for local control of pediatric solid tumors after subtotal resection surgery
spellingShingle	SN-38-loaded nanofiber matrices for local control of pediatric solid tumors after subtotal resection surgery Monterrubio, Carles Nanofibers Chemotherapy Tumors in children--Chemotherapy Pharmacokinetics Microdialysis--methods Local chemotherapy delivery SN-38 Poly(lactic acid) electrospun nanofibers Pediatric solid tumor Pharmacokinetics Microdialysis Nanofibres Quimioteràpia Farmacocinètica Tumors -- Tractament Àrees temàtiques de la UPC::Enginyeria tèxtil::Teixits::Teixits mèdics Àrees temàtiques de la UPC::Ciències de la salut::Medicina
title_short	SN-38-loaded nanofiber matrices for local control of pediatric solid tumors after subtotal resection surgery
title_full	SN-38-loaded nanofiber matrices for local control of pediatric solid tumors after subtotal resection surgery
title_fullStr	SN-38-loaded nanofiber matrices for local control of pediatric solid tumors after subtotal resection surgery
title_full_unstemmed	SN-38-loaded nanofiber matrices for local control of pediatric solid tumors after subtotal resection surgery
title_sort	SN-38-loaded nanofiber matrices for local control of pediatric solid tumors after subtotal resection surgery
dc.creator.none.fl_str_mv	Monterrubio, Carles Pascual Pasto, Guillem Cano Casas, Francesc\|\|\|0000-0002-4920-2194 Vilà Ubach, Mònica Manzanares Quintela, Alejandro Schaiqueviche, Paula Tornero García, José Antonio\|\|\|0000-0001-9479-825X Sosnik, alejandro Mora Graupera, Jaume Montero Carcaboso, Ángel
author	Monterrubio, Carles
author_facet	Monterrubio, Carles Pascual Pasto, Guillem Cano Casas, Francesc\|\|\|0000-0002-4920-2194 Vilà Ubach, Mònica Manzanares Quintela, Alejandro Schaiqueviche, Paula Tornero García, José Antonio\|\|\|0000-0001-9479-825X Sosnik, alejandro Mora Graupera, Jaume Montero Carcaboso, Ángel
author_role	author
author2	Pascual Pasto, Guillem Cano Casas, Francesc\|\|\|0000-0002-4920-2194 Vilà Ubach, Mònica Manzanares Quintela, Alejandro Schaiqueviche, Paula Tornero García, José Antonio\|\|\|0000-0001-9479-825X Sosnik, alejandro Mora Graupera, Jaume Montero Carcaboso, Ángel
author2_role	author author author author author author author author author
dc.subject.none.fl_str_mv	Nanofibers Chemotherapy Tumors in children--Chemotherapy Pharmacokinetics Microdialysis--methods Local chemotherapy delivery SN-38 Poly(lactic acid) electrospun nanofibers Pediatric solid tumor Pharmacokinetics Microdialysis Nanofibres Quimioteràpia Farmacocinètica Tumors -- Tractament Àrees temàtiques de la UPC::Enginyeria tèxtil::Teixits::Teixits mèdics Àrees temàtiques de la UPC::Ciències de la salut::Medicina
topic	Nanofibers Chemotherapy Tumors in children--Chemotherapy Pharmacokinetics Microdialysis--methods Local chemotherapy delivery SN-38 Poly(lactic acid) electrospun nanofibers Pediatric solid tumor Pharmacokinetics Microdialysis Nanofibres Quimioteràpia Farmacocinètica Tumors -- Tractament Àrees temàtiques de la UPC::Enginyeria tèxtil::Teixits::Teixits mèdics Àrees temàtiques de la UPC::Ciències de la salut::Medicina
description	In addition to surgery, local tumor control in pediatric oncology requires new treatments as an alternative to radiotherapy. SN-38 is an anticancer drug with proved activity against several pediatric solid tumors including neuroblastoma, rhabdomyosarcoma and Ewing sarcoma. Taking advantage of the extremely low aqueous solubility of SN-38, we have developed a novel drug delivery system (DDS) consisting of matrices made of poly(lactic acid) electrospun polymer nanofibers loaded with SN-38 microcrystals for local release in difficult-to-treat pediatric solid tumors. To model the clinical scenario, we conducted extensive preclinical experiments to characterize the biodistribution of the released SN-38 using microdialysis sampling in vivo. We observed that the drug achieves high concentrations in the virtual space of the surgical bed and penetrates a maximum distance of 2 mm within the tumor bulk. Subsequently, we developed a model of subtotal tumor resection in clinically relevant pediatric patient-derived xenografts and used such models to provide evidence of the activity of the SN-38 DDS to inhibit tumor regrowth. We propose that this novel DDS could represent a potential future strategy to avoid harmful radiation therapy as a primary tumor control together with surgery
publishDate	2015
dc.date.none.fl_str_mv	2015 2015-12-02 2016 2016-01-21
dc.type.none.fl_str_mv	journal article http://purl.org/coar/resource_type/c_6501 AM http://purl.org/coar/version/c_ab4af688f83e57aa
dc.type.openaire.fl_str_mv	info:eu-repo/semantics/article
format	article
dc.identifier.none.fl_str_mv	https://hdl.handle.net/2117/81791 https://dx.doi.org/10.1016/j.biomaterials.2015.11.055
url	https://hdl.handle.net/2117/81791 https://dx.doi.org/10.1016/j.biomaterials.2015.11.055
dc.language.none.fl_str_mv	Inglés eng
language_invalid_str_mv	Inglés
language	eng
dc.rights.none.fl_str_mv	open access http://purl.org/coar/access_right/c_abf2
dc.rights.openaire.fl_str_mv	info:eu-repo/semantics/openAccess
rights_invalid_str_mv	open access http://purl.org/coar/access_right/c_abf2
eu_rights_str_mv	openAccess
dc.format.none.fl_str_mv	application/pdf
dc.source.none.fl_str_mv	reponame:UPCommons. Portal del coneixement obert de la UPC instname:Universitat Politècnica de Catalunya (UPC)
instname_str	Universitat Politècnica de Catalunya (UPC)
reponame_str	UPCommons. Portal del coneixement obert de la UPC
collection	UPCommons. Portal del coneixement obert de la UPC
repository.name.fl_str_mv
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SN-38-loaded nanofiber matrices for local control of pediatric solid tumors after subtotal resection surgery

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