The rise of serotype 8 is associated with lineages and mutations in the capsular operon with different potential to produce invasive pneumococcal disease

Despite conjugate vaccine introduction to prevent invasive pneumococcal disease (IPD), serotype replacement by non-vaccine serotypes is a constant concern. In this study, we elucidate the rise of serotype 8 causing IPD in Spain. We evaluated isolates received during the period 2008-2023 including wh...

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Autores: Pérez García, Covadonga, González Díaz, Aida, Domenech, Mirian, Llamosí, Mirella, Úbeda, Aída, Sanz, Juan Carlos, García, Ernesto, Ardanuy Tisaire, María Carmen, Sempere, Julio, Yuste, José Enrique
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2025
País:España
Institución:Universidad de Barcelona
Repositorio:Dipòsit Digital de la UB
OAI Identifier:oai:diposit.ub.edu:2445/222835
Acceso en línea:https://hdl.handle.net/2445/222835
Access Level:acceso abierto
Palabra clave:Infeccions per pneumococs
Vacuna antipneumocòccica
Pneumococcal Infections
Pneumococcal vaccine
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spelling The rise of serotype 8 is associated with lineages and mutations in the capsular operon with different potential to produce invasive pneumococcal diseasePérez García, CovadongaGonzález Díaz, AidaDomenech, MirianLlamosí, MirellaÚbeda, AídaSanz, Juan CarlosGarcía, ErnestoArdanuy Tisaire, María CarmenSempere, JulioYuste, José EnriqueInfeccions per pneumococsVacuna antipneumocòccicaPneumococcal InfectionsPneumococcal vaccineDespite conjugate vaccine introduction to prevent invasive pneumococcal disease (IPD), serotype replacement by non-vaccine serotypes is a constant concern. In this study, we elucidate the rise of serotype 8 causing IPD in Spain. We evaluated isolates received during the period 2008-2023 including whole genome sequencing characterization and host-pathogen interaction studies. Serotype 8 has emerged as one of the most prevalent serotypes causing IPD in both children and adults. CC53/GPSC3 carrying pspC 6.11 was the dominant lineage in recent years, displaying increased adhesion to lung cells, enhanced biofilm formation, higher factor H recruitment, improved phagocytosis evasion, and greater virulence in a mice pneumonia model than other co-circulating lineages which could explain its predominance. Morphologically, serotype 8 strains exhibit two appearances on blood agar plates: mucoid colonies, and non-mucoid variants. Molecular characterization revealed that non-mucoid variants harbour mutations in the wchA gene and/or others within the capsular operon, leading to increased adhesion and biofilm formation, albeit with reduced immune evasion capacity. Serotype 8 has become a major cause of IPD, with CC53/GPSC3 as the dominant lineage due to its pathogenic advantages. The versatility of the capsular operon contributes to its success in causing IPD. The use of vaccines with broader coverage, such as PCV20 or PCV21, containing this serotype, may offer an effective strategy to ameliorate the impact on IPD by serotype 8.Informa UK Limited2025info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://hdl.handle.net/2445/222835Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))reponame:Dipòsit Digital de la UBinstname:Universidad de BarcelonaInglésReproducció del document publicat a: https://doi.org/10.1080/22221751.2025.2521845Emerging Microbes & Infections, 2025, vol. 14, num. 1https://doi.org/10.1080/22221751.2025.2521845cc-by (c) Pérez García, Covadonga et al., 2025http://creativecommons.org/licenses/by/3.0/es/info:eu-repo/semantics/openAccessoai:diposit.ub.edu:2445/2228352026-05-27T06:46:51Z
dc.title.none.fl_str_mv The rise of serotype 8 is associated with lineages and mutations in the capsular operon with different potential to produce invasive pneumococcal disease
title The rise of serotype 8 is associated with lineages and mutations in the capsular operon with different potential to produce invasive pneumococcal disease
spellingShingle The rise of serotype 8 is associated with lineages and mutations in the capsular operon with different potential to produce invasive pneumococcal disease
Pérez García, Covadonga
Infeccions per pneumococs
Vacuna antipneumocòccica
Pneumococcal Infections
Pneumococcal vaccine
title_short The rise of serotype 8 is associated with lineages and mutations in the capsular operon with different potential to produce invasive pneumococcal disease
title_full The rise of serotype 8 is associated with lineages and mutations in the capsular operon with different potential to produce invasive pneumococcal disease
title_fullStr The rise of serotype 8 is associated with lineages and mutations in the capsular operon with different potential to produce invasive pneumococcal disease
title_full_unstemmed The rise of serotype 8 is associated with lineages and mutations in the capsular operon with different potential to produce invasive pneumococcal disease
title_sort The rise of serotype 8 is associated with lineages and mutations in the capsular operon with different potential to produce invasive pneumococcal disease
dc.creator.none.fl_str_mv Pérez García, Covadonga
González Díaz, Aida
Domenech, Mirian
Llamosí, Mirella
Úbeda, Aída
Sanz, Juan Carlos
García, Ernesto
Ardanuy Tisaire, María Carmen
Sempere, Julio
Yuste, José Enrique
author Pérez García, Covadonga
author_facet Pérez García, Covadonga
González Díaz, Aida
Domenech, Mirian
Llamosí, Mirella
Úbeda, Aída
Sanz, Juan Carlos
García, Ernesto
Ardanuy Tisaire, María Carmen
Sempere, Julio
Yuste, José Enrique
author_role author
author2 González Díaz, Aida
Domenech, Mirian
Llamosí, Mirella
Úbeda, Aída
Sanz, Juan Carlos
García, Ernesto
Ardanuy Tisaire, María Carmen
Sempere, Julio
Yuste, José Enrique
author2_role author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Infeccions per pneumococs
Vacuna antipneumocòccica
Pneumococcal Infections
Pneumococcal vaccine
topic Infeccions per pneumococs
Vacuna antipneumocòccica
Pneumococcal Infections
Pneumococcal vaccine
description Despite conjugate vaccine introduction to prevent invasive pneumococcal disease (IPD), serotype replacement by non-vaccine serotypes is a constant concern. In this study, we elucidate the rise of serotype 8 causing IPD in Spain. We evaluated isolates received during the period 2008-2023 including whole genome sequencing characterization and host-pathogen interaction studies. Serotype 8 has emerged as one of the most prevalent serotypes causing IPD in both children and adults. CC53/GPSC3 carrying pspC 6.11 was the dominant lineage in recent years, displaying increased adhesion to lung cells, enhanced biofilm formation, higher factor H recruitment, improved phagocytosis evasion, and greater virulence in a mice pneumonia model than other co-circulating lineages which could explain its predominance. Morphologically, serotype 8 strains exhibit two appearances on blood agar plates: mucoid colonies, and non-mucoid variants. Molecular characterization revealed that non-mucoid variants harbour mutations in the wchA gene and/or others within the capsular operon, leading to increased adhesion and biofilm formation, albeit with reduced immune evasion capacity. Serotype 8 has become a major cause of IPD, with CC53/GPSC3 as the dominant lineage due to its pathogenic advantages. The versatility of the capsular operon contributes to its success in causing IPD. The use of vaccines with broader coverage, such as PCV20 or PCV21, containing this serotype, may offer an effective strategy to ameliorate the impact on IPD by serotype 8.
publishDate 2025
dc.date.none.fl_str_mv 2025
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/2445/222835
url https://hdl.handle.net/2445/222835
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Reproducció del document publicat a: https://doi.org/10.1080/22221751.2025.2521845
Emerging Microbes & Infections, 2025, vol. 14, num. 1
https://doi.org/10.1080/22221751.2025.2521845
dc.rights.none.fl_str_mv cc-by (c) Pérez García, Covadonga et al., 2025
http://creativecommons.org/licenses/by/3.0/es/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv cc-by (c) Pérez García, Covadonga et al., 2025
http://creativecommons.org/licenses/by/3.0/es/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Informa UK Limited
publisher.none.fl_str_mv Informa UK Limited
dc.source.none.fl_str_mv Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))
reponame:Dipòsit Digital de la UB
instname:Universidad de Barcelona
instname_str Universidad de Barcelona
reponame_str Dipòsit Digital de la UB
collection Dipòsit Digital de la UB
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,811543

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