Development of A New Delivery System Based on Drug-Loadable Electrospun Nanofibers for Psoriasis Treatment

Psoriasis is a chronic autoimmune systemic disease with an approximate incidence of 2% worldwide; it is commonly characterized by squamous lesions on the skin that present the typical pain, stinging, and bleeding associated with an inflammatory response. In this work, poly(methyl vinyl ether-alt-mal...

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Autores: Martínez-Ortega, Leticia, MIRA CARRIÓ, AMALIA, Fernandez-Carvajal, Asia, Mateo , C. Reyes, Mallavia, Ricardo, Falcó, Alberto
Tipo de recurso: artículo
Fecha de publicación:2018
País:España
Institución:Universidad Miguel Hernández de Elche
Repositorio:REDIUMH. Depósito Digital de la UMH
OAI Identifier:oai:dspace.umh.es:11000/30741
Acceso en línea:https://hdl.handle.net/11000/30741
Access Level:acceso abierto
Palabra clave:PMVE/MA
electrospinning
nanofibers
capsaicin
psoriasis
TRPV1
Química Física
CDU::5 - Ciencias puras y naturales::54 - Química
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spelling Development of A New Delivery System Based on Drug-Loadable Electrospun Nanofibers for Psoriasis TreatmentMartínez-Ortega, LeticiaMIRA CARRIÓ, AMALIAFernandez-Carvajal, AsiaMateo , C. ReyesMallavia, RicardoFalcó, AlbertoPMVE/MAelectrospinningnanofiberscapsaicinpsoriasisTRPV1Química FísicaCDU::5 - Ciencias puras y naturales::54 - QuímicaPsoriasis is a chronic autoimmune systemic disease with an approximate incidence of 2% worldwide; it is commonly characterized by squamous lesions on the skin that present the typical pain, stinging, and bleeding associated with an inflammatory response. In this work, poly(methyl vinyl ether-alt-maleic ethyl monoester) (PMVEMA-ES) nanofibers have been designed as a delivery vehicle for three therapeutic agents with palliative properties for the symptoms of this disease (salicylic acid, methyl salicylate, and capsaicin). For such a task, the production of these nanofibers by means of the electrospinning technique has been optimized. Their morphology and size have been characterized by optical microscopy and scanning electron microscopy (SEM). By selecting the optimal conditions to achieve the smallest and most uniform nanofibers, approximate diameters of up to 800–900 nm were obtained. It was also determined that the therapeutic agents that were used were encapsulated with high efficiency. The analysis of their stability over time by GC-MS showed no significant losses of the encapsulated compounds 15 days after their preparation, except in the case of methyl salicylate. Likewise, it was demonstrated that the therapeutic compounds that were encapsulated conserved, and even improved, their capacity to activate the transient receptor potential cation channel 1 (TRPV1) channel, which has been associated with the formation of psoriatic lesions.MDPIDepartamentos de la UMH::Agroquímica y Medio Ambiente202420242018info:eu-repo/semantics/articleapplication/pdf14application/pdfhttps://hdl.handle.net/11000/30741reponame:REDIUMH. Depósito Digital de la UMHinstname:Universidad Miguel Hernández de ElcheIngléshttps://doi.org/10.3390/pharmaceutics11010014info:eu-repo/semantics/openAccessAttribution-NonCommercial-NoDerivatives 4.0 Internacionalhttp://creativecommons.org/licenses/by-nc-nd/4.0/oai:dspace.umh.es:11000/307412026-05-27T13:36:21Z
dc.title.none.fl_str_mv Development of A New Delivery System Based on Drug-Loadable Electrospun Nanofibers for Psoriasis Treatment
title Development of A New Delivery System Based on Drug-Loadable Electrospun Nanofibers for Psoriasis Treatment
spellingShingle Development of A New Delivery System Based on Drug-Loadable Electrospun Nanofibers for Psoriasis Treatment
Martínez-Ortega, Leticia
PMVE/MA
electrospinning
nanofibers
capsaicin
psoriasis
TRPV1
Química Física
CDU::5 - Ciencias puras y naturales::54 - Química
title_short Development of A New Delivery System Based on Drug-Loadable Electrospun Nanofibers for Psoriasis Treatment
title_full Development of A New Delivery System Based on Drug-Loadable Electrospun Nanofibers for Psoriasis Treatment
title_fullStr Development of A New Delivery System Based on Drug-Loadable Electrospun Nanofibers for Psoriasis Treatment
title_full_unstemmed Development of A New Delivery System Based on Drug-Loadable Electrospun Nanofibers for Psoriasis Treatment
title_sort Development of A New Delivery System Based on Drug-Loadable Electrospun Nanofibers for Psoriasis Treatment
dc.creator.none.fl_str_mv Martínez-Ortega, Leticia
MIRA CARRIÓ, AMALIA
Fernandez-Carvajal, Asia
Mateo , C. Reyes
Mallavia, Ricardo
Falcó, Alberto
author Martínez-Ortega, Leticia
author_facet Martínez-Ortega, Leticia
MIRA CARRIÓ, AMALIA
Fernandez-Carvajal, Asia
Mateo , C. Reyes
Mallavia, Ricardo
Falcó, Alberto
author_role author
author2 MIRA CARRIÓ, AMALIA
Fernandez-Carvajal, Asia
Mateo , C. Reyes
Mallavia, Ricardo
Falcó, Alberto
author2_role author
author
author
author
author
dc.contributor.none.fl_str_mv Departamentos de la UMH::Agroquímica y Medio Ambiente
dc.subject.none.fl_str_mv PMVE/MA
electrospinning
nanofibers
capsaicin
psoriasis
TRPV1
Química Física
CDU::5 - Ciencias puras y naturales::54 - Química
topic PMVE/MA
electrospinning
nanofibers
capsaicin
psoriasis
TRPV1
Química Física
CDU::5 - Ciencias puras y naturales::54 - Química
description Psoriasis is a chronic autoimmune systemic disease with an approximate incidence of 2% worldwide; it is commonly characterized by squamous lesions on the skin that present the typical pain, stinging, and bleeding associated with an inflammatory response. In this work, poly(methyl vinyl ether-alt-maleic ethyl monoester) (PMVEMA-ES) nanofibers have been designed as a delivery vehicle for three therapeutic agents with palliative properties for the symptoms of this disease (salicylic acid, methyl salicylate, and capsaicin). For such a task, the production of these nanofibers by means of the electrospinning technique has been optimized. Their morphology and size have been characterized by optical microscopy and scanning electron microscopy (SEM). By selecting the optimal conditions to achieve the smallest and most uniform nanofibers, approximate diameters of up to 800–900 nm were obtained. It was also determined that the therapeutic agents that were used were encapsulated with high efficiency. The analysis of their stability over time by GC-MS showed no significant losses of the encapsulated compounds 15 days after their preparation, except in the case of methyl salicylate. Likewise, it was demonstrated that the therapeutic compounds that were encapsulated conserved, and even improved, their capacity to activate the transient receptor potential cation channel 1 (TRPV1) channel, which has been associated with the formation of psoriatic lesions.
publishDate 2018
dc.date.none.fl_str_mv 2018
2024
2024
dc.type.none.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv https://hdl.handle.net/11000/30741
url https://hdl.handle.net/11000/30741
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv https://doi.org/10.3390/pharmaceutics11010014
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
Attribution-NonCommercial-NoDerivatives 4.0 Internacional
http://creativecommons.org/licenses/by-nc-nd/4.0/
eu_rights_str_mv openAccess
rights_invalid_str_mv Attribution-NonCommercial-NoDerivatives 4.0 Internacional
http://creativecommons.org/licenses/by-nc-nd/4.0/
dc.format.none.fl_str_mv application/pdf
14
application/pdf
dc.publisher.none.fl_str_mv MDPI
publisher.none.fl_str_mv MDPI
dc.source.none.fl_str_mv reponame:REDIUMH. Depósito Digital de la UMH
instname:Universidad Miguel Hernández de Elche
instname_str Universidad Miguel Hernández de Elche
reponame_str REDIUMH. Depósito Digital de la UMH
collection REDIUMH. Depósito Digital de la UMH
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,301603

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