Nanocarriers for Delivery of Antioxidants on the Skin

Skin is protected from the harmful effects of free radicals by the presence of an endogenous antioxidant system. However, when exposed to ultraviolet (UV) radiation, there is an imbalance between pro-oxidants and antioxidants, leading to oxidative stress and photoaging of the skin. It has been descr...

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Detalles Bibliográficos
Autores: Vinardell Martínez-Hidalgo, Ma. Pilar, Mitjans Arnal, Montserrat
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2015
País:España
Institución:Universidad de Barcelona
Repositorio:Dipòsit Digital de la UB
OAI Identifier:oai:diposit.ub.edu:2445/157420
Acceso en línea:https://hdl.handle.net/2445/157420
Access Level:acceso abierto
Palabra clave:Antioxidants
Pell
Radiació ultraviolada
Càncer de pell
Indústria cosmètica
Skin
Ultraviolet radiation
Skin cancer
Cosmetics industry
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spelling Nanocarriers for Delivery of Antioxidants on the SkinVinardell Martínez-Hidalgo, Ma. PilarMitjans Arnal, MontserratAntioxidantsPellRadiació ultravioladaCàncer de pellIndústria cosmèticaAntioxidantsSkinUltraviolet radiationSkin cancerCosmetics industrySkin is protected from the harmful effects of free radicals by the presence of an endogenous antioxidant system. However, when exposed to ultraviolet (UV) radiation, there is an imbalance between pro-oxidants and antioxidants, leading to oxidative stress and photoaging of the skin. It has been described that free radicals and other reactive species can cause severe damage to cells and cell components of the skin, which results in skin aging and cancer. To prevent these actions on skin, the use of topical antioxidant supplementation is a strategy used in the cosmetics industry and these antioxidants act on quenching free radicals. There are many studies that demonstrated the antioxidant activity of many phytochemicals or bioactive compounds by free radical scavenging. However, many bioactive substances are unstable when exposed to light or lose activity during storage. The potential sensitivity of these substances to light exposure is of importance in cosmetic formulations applied to skin because photo-degradation might occur, reducing their activity. One strategy to reduce this effect on the skin is the preparation of different types of nanomaterials that allow the encapsulation of the antioxidant substances. Another problem related to some antioxidants is their inefficient percutaneous penetration, which limits the amount of the active ingredient able to reach the site of action in viable epidermis and dermis. In this sense, the encapsulation in polymeric nanoparticles could enhance the permeation of these substances. Nanocarriers offers several advantages over conventional passive delivery, such as increased surface area, higher solubility, improved stability, controlled release, reduced skin irritancy, and protection from degradation. The different nanocarrier systems used in cosmetics include nanolipid delivery systems such as solid lipid nanoparticles (SLN) and nanostructured lipid carriers (NLC), nanoemulsions (NEs), nanoparticles (NP) suspension, and polymer NPs, among others. In this review, we present the different types of nanomaterials usedMDPI2015info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://hdl.handle.net/2445/157420Articles publicats en revistes (Bioquímica i Fisiologia)reponame:Dipòsit Digital de la UBinstname:Universidad de BarcelonaInglésReproducció del document publicat a: https://doi.org/10.3390/cosmetics2040342Cosmetics, 2015, vol. 2, num. 4, p. 342-354https://doi.org/10.3390/cosmetics2040342cc-by (c) Vinardell Martínez-Hidalgo, Ma. Pilar et al., 2015http://creativecommons.org/licenses/by/3.0/esinfo:eu-repo/semantics/openAccessoai:diposit.ub.edu:2445/1574202026-05-27T06:46:51Z
dc.title.none.fl_str_mv Nanocarriers for Delivery of Antioxidants on the Skin
title Nanocarriers for Delivery of Antioxidants on the Skin
spellingShingle Nanocarriers for Delivery of Antioxidants on the Skin
Vinardell Martínez-Hidalgo, Ma. Pilar
Antioxidants
Pell
Radiació ultraviolada
Càncer de pell
Indústria cosmètica
Antioxidants
Skin
Ultraviolet radiation
Skin cancer
Cosmetics industry
title_short Nanocarriers for Delivery of Antioxidants on the Skin
title_full Nanocarriers for Delivery of Antioxidants on the Skin
title_fullStr Nanocarriers for Delivery of Antioxidants on the Skin
title_full_unstemmed Nanocarriers for Delivery of Antioxidants on the Skin
title_sort Nanocarriers for Delivery of Antioxidants on the Skin
dc.creator.none.fl_str_mv Vinardell Martínez-Hidalgo, Ma. Pilar
Mitjans Arnal, Montserrat
author Vinardell Martínez-Hidalgo, Ma. Pilar
author_facet Vinardell Martínez-Hidalgo, Ma. Pilar
Mitjans Arnal, Montserrat
author_role author
author2 Mitjans Arnal, Montserrat
author2_role author
dc.subject.none.fl_str_mv Antioxidants
Pell
Radiació ultraviolada
Càncer de pell
Indústria cosmètica
Antioxidants
Skin
Ultraviolet radiation
Skin cancer
Cosmetics industry
topic Antioxidants
Pell
Radiació ultraviolada
Càncer de pell
Indústria cosmètica
Antioxidants
Skin
Ultraviolet radiation
Skin cancer
Cosmetics industry
description Skin is protected from the harmful effects of free radicals by the presence of an endogenous antioxidant system. However, when exposed to ultraviolet (UV) radiation, there is an imbalance between pro-oxidants and antioxidants, leading to oxidative stress and photoaging of the skin. It has been described that free radicals and other reactive species can cause severe damage to cells and cell components of the skin, which results in skin aging and cancer. To prevent these actions on skin, the use of topical antioxidant supplementation is a strategy used in the cosmetics industry and these antioxidants act on quenching free radicals. There are many studies that demonstrated the antioxidant activity of many phytochemicals or bioactive compounds by free radical scavenging. However, many bioactive substances are unstable when exposed to light or lose activity during storage. The potential sensitivity of these substances to light exposure is of importance in cosmetic formulations applied to skin because photo-degradation might occur, reducing their activity. One strategy to reduce this effect on the skin is the preparation of different types of nanomaterials that allow the encapsulation of the antioxidant substances. Another problem related to some antioxidants is their inefficient percutaneous penetration, which limits the amount of the active ingredient able to reach the site of action in viable epidermis and dermis. In this sense, the encapsulation in polymeric nanoparticles could enhance the permeation of these substances. Nanocarriers offers several advantages over conventional passive delivery, such as increased surface area, higher solubility, improved stability, controlled release, reduced skin irritancy, and protection from degradation. The different nanocarrier systems used in cosmetics include nanolipid delivery systems such as solid lipid nanoparticles (SLN) and nanostructured lipid carriers (NLC), nanoemulsions (NEs), nanoparticles (NP) suspension, and polymer NPs, among others. In this review, we present the different types of nanomaterials used
publishDate 2015
dc.date.none.fl_str_mv 2015
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/2445/157420
url https://hdl.handle.net/2445/157420
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Reproducció del document publicat a: https://doi.org/10.3390/cosmetics2040342
Cosmetics, 2015, vol. 2, num. 4, p. 342-354
https://doi.org/10.3390/cosmetics2040342
dc.rights.none.fl_str_mv cc-by (c) Vinardell Martínez-Hidalgo, Ma. Pilar et al., 2015
http://creativecommons.org/licenses/by/3.0/es
info:eu-repo/semantics/openAccess
rights_invalid_str_mv cc-by (c) Vinardell Martínez-Hidalgo, Ma. Pilar et al., 2015
http://creativecommons.org/licenses/by/3.0/es
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv MDPI
publisher.none.fl_str_mv MDPI
dc.source.none.fl_str_mv Articles publicats en revistes (Bioquímica i Fisiologia)
reponame:Dipòsit Digital de la UB
instname:Universidad de Barcelona
instname_str Universidad de Barcelona
reponame_str Dipòsit Digital de la UB
collection Dipòsit Digital de la UB
repository.name.fl_str_mv
repository.mail.fl_str_mv
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