Endothelial dysfunction and subclinical atheromatosis in patients with systemic sclerosis.

Objectives: To assess subclinical vascular features in patients with systemic sclerosis (SSc) via carotid ultrasound, and flow-mediated vasodilation (FMD), as measures of cardiovascular risk (CVR). Methods: This was a cross-sectional study of 70 patients diagnosed with SSc (diffuse or limited forms)...

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Autores: González-Martín, J.J., Novella-Navarro, M., Cabrera-Alarcón, J.L., Carrión, O., Abdelkader, A., Aramburu, F., Alcocer, P., Sainz, F., García De La Peña, P., Calvo Aranda, Enrique
Tipo de recurso: artículo
Fecha de publicación:2020
País:España
Institución:Universidad Alfonso X el Sabio
Repositorio:Repositorio Institucional de la Universidad Alfonso X el Sabio
Idioma:inglés
OAI Identifier:oai:archive.uax.com:20.500.12080/52805
Acceso en línea:https://hdl.handle.net/20.500.12080/52805
Access Level:acceso abierto
Palabra clave:Esclerosis sistémica
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spelling Endothelial dysfunction and subclinical atheromatosis in patients with systemic sclerosis.González-Martín, J.J.Novella-Navarro, M.Cabrera-Alarcón, J.L.Carrión, O.Abdelkader, A.Aramburu, F.Alcocer, P.Sainz, F.García De La Peña, P.Calvo Aranda, EnriqueEsclerosis sistémicaObjectives: To assess subclinical vascular features in patients with systemic sclerosis (SSc) via carotid ultrasound, and flow-mediated vasodilation (FMD), as measures of cardiovascular risk (CVR). Methods: This was a cross-sectional study of 70 patients diagnosed with SSc (diffuse or limited forms), on whom a vascular study protocol was performed to assess angiodynamic parameters measured by FMD in brachial artery and carotid ultrasound lesions: carotid intima-media thickness (CIMT) and carotid atheroma plaques (AP). Classical CVR factors were also assessed, as well as main features of SSc regarding skin and organic involvement, laboratory parameters, presence of autoantibodies and specific treatments. Results: 94% of patients were women with a mean age of 50.2±12.5 years. 84% had endothelial dysfunction (ED), being severe in 49%, statistically associated with glucocorticoid (GC) treatment (OR=8.78; CI=1.52-50.78; p=0.015). CIMT was pathological in 39%, 23% had AP (none had significative haemo-dymanic stenosis). Serum vitamin D concentration (25(OH)D3) showed a protective effect on CIMT (OR=0.94; CI=0.89-0.99; p=0.025). No differences between types of SSc were obtained; neither association between SSc features and classical CVR factors. Conclusions: GC treatment has implications in CVR, despite in SSc GC doses administered are lower than in other autoimmune diseases (in our cohort even prednisone ≤10 mg daily was associated with ED). GC may be associated with an early vascular damage in these patients, which could lead to changes in FMD, ED and finally AP. On the other hand, optimum levels of 25(OH)D3 seemed to be beneficial against vascular damage.UAX -Campus MadridUAX Archive20202020-01-0120202020-01-01journal articlehttp://purl.org/coar/resource_type/c_6501info:eu-repo/semantics/articleapplication/pdfhttps://hdl.handle.net/20.500.12080/52805reponame:Repositorio Institucional de la Universidad Alfonso X el Sabioinstname:Universidad Alfonso X el SabioInglésengopen accesshttp://purl.org/coar/access_right/c_abf2Attribution 4.0 Internationalhttp://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:archive.uax.com:20.500.12080/528052026-05-28T12:40:21Z
dc.title.none.fl_str_mv Endothelial dysfunction and subclinical atheromatosis in patients with systemic sclerosis.
title Endothelial dysfunction and subclinical atheromatosis in patients with systemic sclerosis.
spellingShingle Endothelial dysfunction and subclinical atheromatosis in patients with systemic sclerosis.
González-Martín, J.J.
Esclerosis sistémica
title_short Endothelial dysfunction and subclinical atheromatosis in patients with systemic sclerosis.
title_full Endothelial dysfunction and subclinical atheromatosis in patients with systemic sclerosis.
title_fullStr Endothelial dysfunction and subclinical atheromatosis in patients with systemic sclerosis.
title_full_unstemmed Endothelial dysfunction and subclinical atheromatosis in patients with systemic sclerosis.
title_sort Endothelial dysfunction and subclinical atheromatosis in patients with systemic sclerosis.
dc.creator.none.fl_str_mv González-Martín, J.J.
Novella-Navarro, M.
Cabrera-Alarcón, J.L.
Carrión, O.
Abdelkader, A.
Aramburu, F.
Alcocer, P.
Sainz, F.
García De La Peña, P.
Calvo Aranda, Enrique
author González-Martín, J.J.
author_facet González-Martín, J.J.
Novella-Navarro, M.
Cabrera-Alarcón, J.L.
Carrión, O.
Abdelkader, A.
Aramburu, F.
Alcocer, P.
Sainz, F.
García De La Peña, P.
Calvo Aranda, Enrique
author_role author
author2 Novella-Navarro, M.
Cabrera-Alarcón, J.L.
Carrión, O.
Abdelkader, A.
Aramburu, F.
Alcocer, P.
Sainz, F.
García De La Peña, P.
Calvo Aranda, Enrique
author2_role author
author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv UAX -Campus Madrid
UAX Archive
dc.subject.none.fl_str_mv Esclerosis sistémica
topic Esclerosis sistémica
description Objectives: To assess subclinical vascular features in patients with systemic sclerosis (SSc) via carotid ultrasound, and flow-mediated vasodilation (FMD), as measures of cardiovascular risk (CVR). Methods: This was a cross-sectional study of 70 patients diagnosed with SSc (diffuse or limited forms), on whom a vascular study protocol was performed to assess angiodynamic parameters measured by FMD in brachial artery and carotid ultrasound lesions: carotid intima-media thickness (CIMT) and carotid atheroma plaques (AP). Classical CVR factors were also assessed, as well as main features of SSc regarding skin and organic involvement, laboratory parameters, presence of autoantibodies and specific treatments. Results: 94% of patients were women with a mean age of 50.2±12.5 years. 84% had endothelial dysfunction (ED), being severe in 49%, statistically associated with glucocorticoid (GC) treatment (OR=8.78; CI=1.52-50.78; p=0.015). CIMT was pathological in 39%, 23% had AP (none had significative haemo-dymanic stenosis). Serum vitamin D concentration (25(OH)D3) showed a protective effect on CIMT (OR=0.94; CI=0.89-0.99; p=0.025). No differences between types of SSc were obtained; neither association between SSc features and classical CVR factors. Conclusions: GC treatment has implications in CVR, despite in SSc GC doses administered are lower than in other autoimmune diseases (in our cohort even prednisone ≤10 mg daily was associated with ED). GC may be associated with an early vascular damage in these patients, which could lead to changes in FMD, ED and finally AP. On the other hand, optimum levels of 25(OH)D3 seemed to be beneficial against vascular damage.
publishDate 2020
dc.date.none.fl_str_mv 2020
2020-01-01
2020
2020-01-01
dc.type.none.fl_str_mv journal article
http://purl.org/coar/resource_type/c_6501
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv https://hdl.handle.net/20.500.12080/52805
url https://hdl.handle.net/20.500.12080/52805
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
Attribution 4.0 International
http://creativecommons.org/licenses/by/4.0/
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
Attribution 4.0 International
http://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv reponame:Repositorio Institucional de la Universidad Alfonso X el Sabio
instname:Universidad Alfonso X el Sabio
instname_str Universidad Alfonso X el Sabio
reponame_str Repositorio Institucional de la Universidad Alfonso X el Sabio
collection Repositorio Institucional de la Universidad Alfonso X el Sabio
repository.name.fl_str_mv
repository.mail.fl_str_mv
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