Obesity and Breast Cancer: Role of Leptin

Obesity-related breast cancer is an important threat that affects especially post-menopausal women. The link between obesity and breast cancer seems to be relying on the microenvironment generated at adipose tissue level, which includes inflammatory cytokines. In addition, its association with syste...

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Detalles Bibliográficos
Autores: Sánchez Jiménez, Flora, Pérez Pérez, Antonio, Cruz Merino, Luis de la, Sánchez Margalet, Víctor
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2019
País:España
Institución:Universidad de Sevilla (US)
Repositorio:idUS. Depósito de Investigación de la Universidad de Sevilla
OAI Identifier:oai:idus.us.es:11441/110902
Acceso en línea:https://hdl.handle.net/11441/110902
https://doi.org/10.3389/fonc.2019.00596
Access Level:acceso abierto
Palabra clave:Breast cancer
Leptin
Leptin receptor
Leptin signaling
Obesity
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spelling Obesity and Breast Cancer: Role of LeptinSánchez Jiménez, FloraPérez Pérez, AntonioCruz Merino, Luis de laSánchez Margalet, VíctorBreast cancerLeptinLeptin receptorLeptin signalingObesityObesity-related breast cancer is an important threat that affects especially post-menopausal women. The link between obesity and breast cancer seems to be relying on the microenvironment generated at adipose tissue level, which includes inflammatory cytokines. In addition, its association with systemic endocrine changes, including hyperinsulinemia, increased estrogens levels, and hyperleptinemia may be key factors for tumor development. These factors may promote tumor initiation, tumor primary growth, tissue invasion, and metastatic progression. Although the relationship between obesity and breast cancer is already established, the different pathophysiological mechanisms involved are not clear. Obesity-related insulin resistance is a well-known risk factor for breast cancer development in post-menopausal women. However, the role of inflammation and other adipokines, especially leptin, is less studied. Leptin, like insulin, appears to be a growth factor for breast cancer cells. There exists a link between leptin and metabolism of estrogens and between leptin and other factors in a more complex network. As a result, obesity-associated hyperleptinemia has been suggested as an important mediator in the pathophysiology of breast cancer. On the other hand, recent data on the paradoxical effect of obesity on cancer immunotherapy efficacy has brought some controversy, since the proinflammatory effect of leptin may help the effect of immune checkpoint inhibitors. Therefore, a better knowledge of the molecular mechanisms that mediate leptin action may be helpful to understand the underlying processes which link obesity to breast cancer in post-menopausal women, as well as the possible role of leptin in the response to immunotherapy in obese patients.The present work was funded by grants from the Instituto de Salud Carlos III (ISCIII), PS12/00117, and PI15/01535, funded in part by FEDER Funds, to VS-M.Bioquímica Médica y Biología Molecular e InmunologíaCirugía2019info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfapplication/pdfhttps://hdl.handle.net/11441/110902https://doi.org/10.3389/fonc.2019.00596reponame:idUS. Depósito de Investigación de la Universidad de Sevillainstname:Universidad de Sevilla (US)InglésFrontiers In Oncology, 9 (596)info:eu-repo/semantics/openAccessoai:idus.us.es:11441/1109022026-06-17T12:51:07Z
dc.title.none.fl_str_mv Obesity and Breast Cancer: Role of Leptin
title Obesity and Breast Cancer: Role of Leptin
spellingShingle Obesity and Breast Cancer: Role of Leptin
Sánchez Jiménez, Flora
Breast cancer
Leptin
Leptin receptor
Leptin signaling
Obesity
title_short Obesity and Breast Cancer: Role of Leptin
title_full Obesity and Breast Cancer: Role of Leptin
title_fullStr Obesity and Breast Cancer: Role of Leptin
title_full_unstemmed Obesity and Breast Cancer: Role of Leptin
title_sort Obesity and Breast Cancer: Role of Leptin
dc.creator.none.fl_str_mv Sánchez Jiménez, Flora
Pérez Pérez, Antonio
Cruz Merino, Luis de la
Sánchez Margalet, Víctor
author Sánchez Jiménez, Flora
author_facet Sánchez Jiménez, Flora
Pérez Pérez, Antonio
Cruz Merino, Luis de la
Sánchez Margalet, Víctor
author_role author
author2 Pérez Pérez, Antonio
Cruz Merino, Luis de la
Sánchez Margalet, Víctor
author2_role author
author
author
dc.contributor.none.fl_str_mv Bioquímica Médica y Biología Molecular e Inmunología
Cirugía
dc.subject.none.fl_str_mv Breast cancer
Leptin
Leptin receptor
Leptin signaling
Obesity
topic Breast cancer
Leptin
Leptin receptor
Leptin signaling
Obesity
description Obesity-related breast cancer is an important threat that affects especially post-menopausal women. The link between obesity and breast cancer seems to be relying on the microenvironment generated at adipose tissue level, which includes inflammatory cytokines. In addition, its association with systemic endocrine changes, including hyperinsulinemia, increased estrogens levels, and hyperleptinemia may be key factors for tumor development. These factors may promote tumor initiation, tumor primary growth, tissue invasion, and metastatic progression. Although the relationship between obesity and breast cancer is already established, the different pathophysiological mechanisms involved are not clear. Obesity-related insulin resistance is a well-known risk factor for breast cancer development in post-menopausal women. However, the role of inflammation and other adipokines, especially leptin, is less studied. Leptin, like insulin, appears to be a growth factor for breast cancer cells. There exists a link between leptin and metabolism of estrogens and between leptin and other factors in a more complex network. As a result, obesity-associated hyperleptinemia has been suggested as an important mediator in the pathophysiology of breast cancer. On the other hand, recent data on the paradoxical effect of obesity on cancer immunotherapy efficacy has brought some controversy, since the proinflammatory effect of leptin may help the effect of immune checkpoint inhibitors. Therefore, a better knowledge of the molecular mechanisms that mediate leptin action may be helpful to understand the underlying processes which link obesity to breast cancer in post-menopausal women, as well as the possible role of leptin in the response to immunotherapy in obese patients.
publishDate 2019
dc.date.none.fl_str_mv 2019
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
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dc.identifier.none.fl_str_mv https://hdl.handle.net/11441/110902
https://doi.org/10.3389/fonc.2019.00596
url https://hdl.handle.net/11441/110902
https://doi.org/10.3389/fonc.2019.00596
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Frontiers In Oncology, 9 (596)
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.source.none.fl_str_mv reponame:idUS. Depósito de Investigación de la Universidad de Sevilla
instname:Universidad de Sevilla (US)
instname_str Universidad de Sevilla (US)
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