Variability in mutational fitness effects prevents full lethal transitions in large quasispecies populations

This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivs 3.0 Unported License. The images in this article are included in the article's Creative Commons license, unless indicated otherwise in the image credit; if the image is not included under the Creative Commons lice...

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Autores: Sardanyés, Josep, Simó, Carles, Solé, Ricard V., Elena, Santiago F.
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2014
País:España
Institución:Consejo Superior de Investigaciones Científicas (CSIC)
Repositorio:DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:oai:digital.csic.es:10261/100726
Acceso en línea:http://hdl.handle.net/10261/100726
Access Level:acceso abierto
id ES_e2615fa61348352da4abfacb2f2a2e64
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spelling Variability in mutational fitness effects prevents full lethal transitions in large quasispecies populationsSardanyés, JosepSimó, CarlesSolé, Ricard V.Elena, Santiago F.This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivs 3.0 Unported License. The images in this article are included in the article's Creative Commons license, unless indicated otherwise in the image credit; if the image is not included under the Creative Commons license, users will need to obtain permission from the license holder in order to reproduce the image.The distribution of mutational fitness effects (DMFE) is crucial to the evolutionary fate of quasispecies. In this article we analyze the effect of the DMFE on the dynamics of a large quasispecies by means of a phenotypic version of the classic Eigen's model that incorporates beneficial, neutral, deleterious, and lethal mutations. By parameterizing the model with available experimental data on the DMFE of Vesicular stomatitis virus (VSV) and Tobacco etch virus (TEV), we found that increasing mutation does not totally push the entire viral quasispecies towards deleterious or lethal regions of the phenotypic sequence space. The probability of finding regions in the parameter space of the general model that results in a quasispecies only composed by lethal phenotypes is extremely small at equilibrium and in transient times. The implications of our findings can be extended to other scenarios, such as lethal mutagenesis or genomically unstable cancer, where increased mutagenesis has been suggested as a potential therapy.This work was partially funded by the Botin Foundation (JS, RVS), by the Spanish Secretaria de Estado de Investigacion, Desarrollo e Innovacion grants MTM2010-16425 (CS, RM) and BFU2012-30805 (SFE), by grant 2009-SGR-67 from the Catalan government (CS, RM), by grant NSF PHY05-51164 (JS, SFE), and by the Santa Fe Institute (RVS, SFE).Peer ReviewedNature Publishing GroupFundación BotínMinisterio de Economía y Competitividad (España)Generalitat de CatalunyaNational Science Foundation (US)Santa Fe Institute (US)Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]2014201420142014info:eu-repo/semantics/articlehttp://purl.org/coar/resource_type/c_6501Publisher's versioninfo:eu-repo/semantics/publishedVersionhttp://hdl.handle.net/10261/100726reponame:DIGITAL.CSIC. Repositorio Institucional del CSICinstname:Consejo Superior de Investigaciones Científicas (CSIC)Ingléshttp://dx.doi.org/10.1038/srep04625Síinfo:eu-repo/semantics/openAccessoai:digital.csic.es:10261/1007262026-05-22T06:33:51Z
dc.title.none.fl_str_mv Variability in mutational fitness effects prevents full lethal transitions in large quasispecies populations
title Variability in mutational fitness effects prevents full lethal transitions in large quasispecies populations
spellingShingle Variability in mutational fitness effects prevents full lethal transitions in large quasispecies populations
Sardanyés, Josep
title_short Variability in mutational fitness effects prevents full lethal transitions in large quasispecies populations
title_full Variability in mutational fitness effects prevents full lethal transitions in large quasispecies populations
title_fullStr Variability in mutational fitness effects prevents full lethal transitions in large quasispecies populations
title_full_unstemmed Variability in mutational fitness effects prevents full lethal transitions in large quasispecies populations
title_sort Variability in mutational fitness effects prevents full lethal transitions in large quasispecies populations
dc.creator.none.fl_str_mv Sardanyés, Josep
Simó, Carles
Solé, Ricard V.
Elena, Santiago F.
author Sardanyés, Josep
author_facet Sardanyés, Josep
Simó, Carles
Solé, Ricard V.
Elena, Santiago F.
author_role author
author2 Simó, Carles
Solé, Ricard V.
Elena, Santiago F.
author2_role author
author
author
dc.contributor.none.fl_str_mv Fundación Botín
Ministerio de Economía y Competitividad (España)
Generalitat de Catalunya
National Science Foundation (US)
Santa Fe Institute (US)
Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]
description This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivs 3.0 Unported License. The images in this article are included in the article's Creative Commons license, unless indicated otherwise in the image credit; if the image is not included under the Creative Commons license, users will need to obtain permission from the license holder in order to reproduce the image.
publishDate 2014
dc.date.none.fl_str_mv 2014
2014
2014
2014
dc.type.none.fl_str_mv info:eu-repo/semantics/article
http://purl.org/coar/resource_type/c_6501
Publisher's version
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10261/100726
url http://hdl.handle.net/10261/100726
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv http://dx.doi.org/10.1038/srep04625
Sí
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Nature Publishing Group
publisher.none.fl_str_mv Nature Publishing Group
dc.source.none.fl_str_mv reponame:DIGITAL.CSIC. Repositorio Institucional del CSIC
instname:Consejo Superior de Investigaciones Científicas (CSIC)
instname_str Consejo Superior de Investigaciones Científicas (CSIC)
reponame_str DIGITAL.CSIC. Repositorio Institucional del CSIC
collection DIGITAL.CSIC. Repositorio Institucional del CSIC
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