Telling true from false: cannabis users show increased susceptibility to false memories

Previous studies on the neurocognitive impact of cannabis use have found working and declarative memory deficits that tend to normalize with abstinence. An unexplored aspect of cognitive function in chronic cannabis users is the ability to distinguish between veridical and illusory memories, a cruci...

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Autores: Riba, Jordi, Valle, Marta, Sampedro, Frederic, Rodriguez Pujadas, Aina, Martínez Horta, Saúl, Kulisevsky, Jaime, Rodríguez Fornells, Antoni
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2015
País:España
Institución:Universidad de Barcelona
Repositorio:Dipòsit Digital de la UB
OAI Identifier:oai:diposit.ub.edu:2445/125342
Acceso en línea:https://hdl.handle.net/2445/125342
Access Level:acceso abierto
Palabra clave:Cànnabis
Neurociència cognitiva
Trastorns de la memòria
Cannabis
Cognitive neuroscience
Memory disorders
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spelling Telling true from false: cannabis users show increased susceptibility to false memoriesRiba, JordiValle, MartaSampedro, FredericRodriguez Pujadas, AinaMartínez Horta, SaúlKulisevsky, JaimeRodríguez Fornells, AntoniCànnabisNeurociència cognitivaTrastorns de la memòriaCannabisCognitive neuroscienceMemory disordersPrevious studies on the neurocognitive impact of cannabis use have found working and declarative memory deficits that tend to normalize with abstinence. An unexplored aspect of cognitive function in chronic cannabis users is the ability to distinguish between veridical and illusory memories, a crucial aspect of reality monitoring that relies on adequate memory function and cognitive control. Using functional magnetic resonance imaging, we show that abstinent cannabis users have an increased susceptibility to false memories, failing to identify lure stimuli as events that never occurred. In addition to impaired performance, cannabis users display reduced activation in areas associated with memory processing within the lateral and medial temporal lobe (MTL), and in parietal and frontal brain regions involved in attention and performance monitoring. Furthermore, cannabis consumption was inversely correlated with MTL activity, suggesting that the drug is especially detrimental to the episodic aspects of memory. These findings indicate that cannabis users have an increased susceptibility to memory distortions even when abstinent and drug-free, suggesting a long-lasting compromise of memory and cognitive control mechanisms involved in reality monitoring.Nature Publishing Group2015info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://hdl.handle.net/2445/125342Articles publicats en revistes (Cognició, Desenvolupament i Psicologia de l'Educació)reponame:Dipòsit Digital de la UBinstname:Universidad de BarcelonaInglésReproducció del document publicat a: https://doi.org/10.1038/mp.2015.36Molecular Psychiatry, 2015, vol. 20, p. 772-777https://doi.org/10.1038/mp.2015.36cc-by-nc-nd (c) Riba, Jordi et al., 2015http://creativecommons.org/licenses/by-nc-nd/3.0/esinfo:eu-repo/semantics/openAccessoai:diposit.ub.edu:2445/1253422026-05-27T06:46:51Z
dc.title.none.fl_str_mv Telling true from false: cannabis users show increased susceptibility to false memories
title Telling true from false: cannabis users show increased susceptibility to false memories
spellingShingle Telling true from false: cannabis users show increased susceptibility to false memories
Riba, Jordi
Cànnabis
Neurociència cognitiva
Trastorns de la memòria
Cannabis
Cognitive neuroscience
Memory disorders
title_short Telling true from false: cannabis users show increased susceptibility to false memories
title_full Telling true from false: cannabis users show increased susceptibility to false memories
title_fullStr Telling true from false: cannabis users show increased susceptibility to false memories
title_full_unstemmed Telling true from false: cannabis users show increased susceptibility to false memories
title_sort Telling true from false: cannabis users show increased susceptibility to false memories
dc.creator.none.fl_str_mv Riba, Jordi
Valle, Marta
Sampedro, Frederic
Rodriguez Pujadas, Aina
Martínez Horta, Saúl
Kulisevsky, Jaime
Rodríguez Fornells, Antoni
author Riba, Jordi
author_facet Riba, Jordi
Valle, Marta
Sampedro, Frederic
Rodriguez Pujadas, Aina
Martínez Horta, Saúl
Kulisevsky, Jaime
Rodríguez Fornells, Antoni
author_role author
author2 Valle, Marta
Sampedro, Frederic
Rodriguez Pujadas, Aina
Martínez Horta, Saúl
Kulisevsky, Jaime
Rodríguez Fornells, Antoni
author2_role author
author
author
author
author
author
dc.subject.none.fl_str_mv Cànnabis
Neurociència cognitiva
Trastorns de la memòria
Cannabis
Cognitive neuroscience
Memory disorders
topic Cànnabis
Neurociència cognitiva
Trastorns de la memòria
Cannabis
Cognitive neuroscience
Memory disorders
description Previous studies on the neurocognitive impact of cannabis use have found working and declarative memory deficits that tend to normalize with abstinence. An unexplored aspect of cognitive function in chronic cannabis users is the ability to distinguish between veridical and illusory memories, a crucial aspect of reality monitoring that relies on adequate memory function and cognitive control. Using functional magnetic resonance imaging, we show that abstinent cannabis users have an increased susceptibility to false memories, failing to identify lure stimuli as events that never occurred. In addition to impaired performance, cannabis users display reduced activation in areas associated with memory processing within the lateral and medial temporal lobe (MTL), and in parietal and frontal brain regions involved in attention and performance monitoring. Furthermore, cannabis consumption was inversely correlated with MTL activity, suggesting that the drug is especially detrimental to the episodic aspects of memory. These findings indicate that cannabis users have an increased susceptibility to memory distortions even when abstinent and drug-free, suggesting a long-lasting compromise of memory and cognitive control mechanisms involved in reality monitoring.
publishDate 2015
dc.date.none.fl_str_mv 2015
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/2445/125342
url https://hdl.handle.net/2445/125342
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Reproducció del document publicat a: https://doi.org/10.1038/mp.2015.36
Molecular Psychiatry, 2015, vol. 20, p. 772-777
https://doi.org/10.1038/mp.2015.36
dc.rights.none.fl_str_mv cc-by-nc-nd (c) Riba, Jordi et al., 2015
http://creativecommons.org/licenses/by-nc-nd/3.0/es
info:eu-repo/semantics/openAccess
rights_invalid_str_mv cc-by-nc-nd (c) Riba, Jordi et al., 2015
http://creativecommons.org/licenses/by-nc-nd/3.0/es
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Nature Publishing Group
publisher.none.fl_str_mv Nature Publishing Group
dc.source.none.fl_str_mv Articles publicats en revistes (Cognició, Desenvolupament i Psicologia de l'Educació)
reponame:Dipòsit Digital de la UB
instname:Universidad de Barcelona
instname_str Universidad de Barcelona
reponame_str Dipòsit Digital de la UB
collection Dipòsit Digital de la UB
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,300719

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