Protective effects of the succinate/SUCNR1 axis on damaged hepatocytes in NAFLD

[Objective]: Succinate and succinate receptor 1 (SUCNR1) are linked to fibrotic remodeling in models of non-alcoholic fatty liver disease (NAFLD), but whether they have roles beyond the activation of hepatic stellate cells remains unexplored. We investigated the succinate/SUCNR1 axis in the context...

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Detalles Bibliográficos
Autores: Marsal-Beltran, Anna, Rodríguez-Castellano, Adrià, Astiarraga, Brenno, Calvo, Enrique, Rada, Patricia, Madeira, Ana, Rodríguez-Peña, M-Mar, Llauradó, Gemma, Núñez-Roa, Catalina, Gómez-Santos, Beatriz, Maymó-Masip, Elsa, Bosch, Ramón, Frutos, María Dolores, Moreno-Navarrete, José María, Ramos-Molina, Bruno, Aspichueta, Patricia, Joven, Jorge, Fernández-Real, José M., Quer, Juan Carlos, Valverde, Ángela M., Pardo, Albert, Vendrell, Joan, Ceperuelo-Mallafré, Victoria, Fernández-Veledo, Sonia
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2023
País:España
Institución:Consejo Superior de Investigaciones Científicas (CSIC)
Repositorio:DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:oai:digital.csic.es:10261/349924
Acceso en línea:http://hdl.handle.net/10261/349924
https://api.elsevier.com/content/abstract/scopus_id/85163772791
Access Level:acceso abierto
Palabra clave:Succinate
SUCNR1
NASH
Steatosis
Hepatocyte
Glycogen
Descripción
Sumario:[Objective]: Succinate and succinate receptor 1 (SUCNR1) are linked to fibrotic remodeling in models of non-alcoholic fatty liver disease (NAFLD), but whether they have roles beyond the activation of hepatic stellate cells remains unexplored. We investigated the succinate/SUCNR1 axis in the context of NAFLD specifically in hepatocytes.

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