A global multinational survey of cefotaxime-resistant coliforms in urban wastewater treatment plants

The World Health Organization Global Action Plan recommends integrated surveillance programs as crucial strategies for monitoring antibiotic resistance. Although several national surveillance programs are in place for clinical and veterinary settings, no such schemes exist for monitoring antibiotic-...

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Autores: Marano, Roberto, Fernandes, Telma, Manaia, Célia, Nunes, Olga, Morrison, Donald, Berendonk, Thomas, Kreuzinger, Norbert, Telson, Tanel, Corno, Gianluca, Fatta-Kassinos, Despo, Merlin, Christophe, Topp, Edward, Jurkevitch, Edouard, Henn, Leonie, Scott, Andrew, Heß, Stefanie, Slipko, Katarzyna, Laht, Mailis, Kisand, Veljo, Di Cesare, Andrea, Karaolia, Popi, Michael, Stella, Petre, Alice, Rosal, Roberto, Pruden, Amy, Riquelme, Virginia, Agüera, Ana, Esteban, Belen, Luczkiewicz, Aneta, Kalinowska, Agnieszka, Leonard, Anne, Gaze, William, Adegoket, Anthony, Stenstrom, Thor, Pollice, Alfieri, Salerno, Carlo, Schwermer, Carsten, Krzeminski, Pawel, Guilloteau, Hélène, Donner, Erica, Drigo, Barbara, Libralato, Giovanni, Guida, Marco, Bürgmann, Helmut, Beck, Karin, Garelick, Hemda, Tacão, Marta, Henriques, Isabel, Martínez-Alcalá, Isabel, Guillén Navarro, José Manuel, Popowska, Magdalena, Piotrowska, Marta, Quintela Baluja, Marcos, Bunce, FJoshua, Polo López, Maria, Nahim–Granados, Samira, Pons, Marie, Milakovic, Milena, Udikovic-Kolic, Nikolina, Ory, Jérôme, Ousmane, Traore, Caballero, Pilar, Oliver, Antoni, Rodriguez Mozaz, Sara, Balcazar, Jose, Jäger, Thomas, Schwartz, Thomas, Yang, Ying, Zou, Shichun, Lee, Yunho, Yoon, Younggun, Herzog, Bastian, Mayrhofer, Heidrum, Prakash, Om, Nimonkar, Yogesh, Heath, Ester, Baraniak, Anna, Abreu Silva, Joana, Choudhury, Manika, Munoz, Leonardo, Krizanovic, Stela, Brunetti, Gianluca, Maile-Moskowitz, Ayella, Brown, Connor, Cytryn, Eddie
Tipo de recurso: artículo
Fecha de publicación:2020
País:España
Institución:Universidad Católica San Antonio de Murcia (UCAM)
Repositorio:RIUCAM. Repositorio Institucional de la Universidad Católica San Antonio de Murcia
OAI Identifier:oai:repositorio.ucam.edu:10952/7820
Acceso en línea:http://hdl.handle.net/10952/7820
https://doi.org/10.1016/j.envint.2020.106035
Access Level:acceso abierto
Palabra clave:Antibiotic resistance
Coliforms
ESBLs
Wastewater treatment
Water reuse
Descripción
Sumario:The World Health Organization Global Action Plan recommends integrated surveillance programs as crucial strategies for monitoring antibiotic resistance. Although several national surveillance programs are in place for clinical and veterinary settings, no such schemes exist for monitoring antibiotic-resistant bacteria in the environment. In this transnational study, we developed, validated, and tested a low-cost surveillance and easy to implement approach to evaluate antibiotic resistance in wastewater treatment plants (WWTPs) by targeting cefotaxime-resistant (CTX-R) coliforms as indicators. The rationale for this approach was: i) coliform quantification methods are internationally accepted as indicators of fecal contamination in recreational waters and are therefore routinely applied in analytical labs; ii) CTX-R coliforms are clinically relevant, associated with extended-spectrum β-lactamases (ESBLs), and are rare in pristine environments. We analyzed 57 WWTPs in 22 countries across Europe, Asia, Africa, Australia, and North America. CTX-R coliforms were ubiquitous in raw sewage and their relative abundance varied significantly (<0.1% to 38.3%), being positively correlated (p < 0.001) with regional atmospheric temperatures. Although most WWTPs removed large proportions of CTX-R coliforms, loads over 103 colony-forming units per mL were occasionally observed in final effluents. We demonstrate that CTX-R coliform monitoring is a feasible and affordable approach to assess wastewater antibiotic resistance status.

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