Formation of Multicolor Nanogels Based on Cationic Polyfluorenes and Poly(methyl vinyl ether-alt-maleic monoethyl ester): Potential Use as pH-Responsive Fluorescent Drug Carriers

In this study, we employed the copolymer poly(methyl vinyl ether-alt-maleic monoethyl ester) (PMVEMA-Es) and three fluorene-based cationic conjugated polyelectrolytes to develop flu orescent nanoparticles with emission in the blue, green and red spectral regions. The size, Zeta Potential, polydisper...

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Detalles Bibliográficos
Autores: Rubio-Camacho, Marta, Martínez Tomé, María José, MIRA CARRIÓ, AMALIA, Mallavia, Ricardo, Reyes Mateo, Carmen
Tipo de recurso: artículo
Fecha de publicación:2021
País:España
Institución:Universidad Miguel Hernández de Elche
Repositorio:REDIUMH. Depósito Digital de la UMH
OAI Identifier:oai:dspace.umh.es:11000/30576
Acceso en línea:https://hdl.handle.net/11000/30576
Access Level:acceso abierto
Palabra clave:nanogels
PMVEMA
fluorescent conjugated polymers
doxorubicin
nanoparticles
drug-delivery
bioimagi
CDU::5 - Ciencias puras y naturales
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spelling Formation of Multicolor Nanogels Based on Cationic Polyfluorenes and Poly(methyl vinyl ether-alt-maleic monoethyl ester): Potential Use as pH-Responsive Fluorescent Drug CarriersRubio-Camacho, MartaMartínez Tomé, María JoséMIRA CARRIÓ, AMALIAMallavia, RicardoReyes Mateo, CarmennanogelsPMVEMAfluorescent conjugated polymersdoxorubicinnanoparticlesdrug-deliverybioimagiCDU::5 - Ciencias puras y naturalesIn this study, we employed the copolymer poly(methyl vinyl ether-alt-maleic monoethyl ester) (PMVEMA-Es) and three fluorene-based cationic conjugated polyelectrolytes to develop flu orescent nanoparticles with emission in the blue, green and red spectral regions. The size, Zeta Potential, polydispersity, morphology, time-stability and fluorescent properties of these nanoparticles were characterized, as well as the nature of the interaction between both PMVEMA-Es and fluorescent polyelectrolytes. Because PMVEMA-Es contains a carboxylic acid group in its structure, the effects of pH and ionic strength on the nanoparticles were also evaluated, finding that the size is responsive to pH and ionic strength, largely swelling at physiological pH and returning to their initial size at acidic pHs. Thus, the developed fluorescent nanoparticles can be categorized as pH-sensitive fluorescent nanogels, since they possess the properties of both pH-responsive hydrogels and nanoparticulate systems. Doxorubicin (DOX) was used as a model drug to show the capacity of the blue-emitting nanogels to hold drugs in acidic media and release them at physiological pH, from changes in the fluorescence properties of both nanoparticles and DOX. In addition, preliminary studies by super-resolution confocal microscopy were performed, regarding their potential use as image probes.MDPIDepartamentos de la UMH::Agroquímica y Medio AmbienteInstitutos de la UMH::Instituto de Investigación, Desarrollo e Innovación en Biotecnología Sanitaria de Elche202420242021info:eu-repo/semantics/articleapplication/pdf23application/pdfapplication/pdfhttps://hdl.handle.net/11000/30576reponame:REDIUMH. Depósito Digital de la UMHinstname:Universidad Miguel Hernández de ElcheInglés22(17)9607https://doi.org/10.3390/ijms22179607info:eu-repo/semantics/openAccesshttp://creativecommons.org/licenses/by-nc-nd/4.0/oai:dspace.umh.es:11000/305762026-05-27T13:36:21Z
dc.title.none.fl_str_mv Formation of Multicolor Nanogels Based on Cationic Polyfluorenes and Poly(methyl vinyl ether-alt-maleic monoethyl ester): Potential Use as pH-Responsive Fluorescent Drug Carriers
title Formation of Multicolor Nanogels Based on Cationic Polyfluorenes and Poly(methyl vinyl ether-alt-maleic monoethyl ester): Potential Use as pH-Responsive Fluorescent Drug Carriers
spellingShingle Formation of Multicolor Nanogels Based on Cationic Polyfluorenes and Poly(methyl vinyl ether-alt-maleic monoethyl ester): Potential Use as pH-Responsive Fluorescent Drug Carriers
Rubio-Camacho, Marta
nanogels
PMVEMA
fluorescent conjugated polymers
doxorubicin
nanoparticles
drug-delivery
bioimagi
CDU::5 - Ciencias puras y naturales
title_short Formation of Multicolor Nanogels Based on Cationic Polyfluorenes and Poly(methyl vinyl ether-alt-maleic monoethyl ester): Potential Use as pH-Responsive Fluorescent Drug Carriers
title_full Formation of Multicolor Nanogels Based on Cationic Polyfluorenes and Poly(methyl vinyl ether-alt-maleic monoethyl ester): Potential Use as pH-Responsive Fluorescent Drug Carriers
title_fullStr Formation of Multicolor Nanogels Based on Cationic Polyfluorenes and Poly(methyl vinyl ether-alt-maleic monoethyl ester): Potential Use as pH-Responsive Fluorescent Drug Carriers
title_full_unstemmed Formation of Multicolor Nanogels Based on Cationic Polyfluorenes and Poly(methyl vinyl ether-alt-maleic monoethyl ester): Potential Use as pH-Responsive Fluorescent Drug Carriers
title_sort Formation of Multicolor Nanogels Based on Cationic Polyfluorenes and Poly(methyl vinyl ether-alt-maleic monoethyl ester): Potential Use as pH-Responsive Fluorescent Drug Carriers
dc.creator.none.fl_str_mv Rubio-Camacho, Marta
Martínez Tomé, María José
MIRA CARRIÓ, AMALIA
Mallavia, Ricardo
Reyes Mateo, Carmen
author Rubio-Camacho, Marta
author_facet Rubio-Camacho, Marta
Martínez Tomé, María José
MIRA CARRIÓ, AMALIA
Mallavia, Ricardo
Reyes Mateo, Carmen
author_role author
author2 Martínez Tomé, María José
MIRA CARRIÓ, AMALIA
Mallavia, Ricardo
Reyes Mateo, Carmen
author2_role author
author
author
author
dc.contributor.none.fl_str_mv Departamentos de la UMH::Agroquímica y Medio Ambiente
Institutos de la UMH::Instituto de Investigación, Desarrollo e Innovación en Biotecnología Sanitaria de Elche
dc.subject.none.fl_str_mv nanogels
PMVEMA
fluorescent conjugated polymers
doxorubicin
nanoparticles
drug-delivery
bioimagi
CDU::5 - Ciencias puras y naturales
topic nanogels
PMVEMA
fluorescent conjugated polymers
doxorubicin
nanoparticles
drug-delivery
bioimagi
CDU::5 - Ciencias puras y naturales
description In this study, we employed the copolymer poly(methyl vinyl ether-alt-maleic monoethyl ester) (PMVEMA-Es) and three fluorene-based cationic conjugated polyelectrolytes to develop flu orescent nanoparticles with emission in the blue, green and red spectral regions. The size, Zeta Potential, polydispersity, morphology, time-stability and fluorescent properties of these nanoparticles were characterized, as well as the nature of the interaction between both PMVEMA-Es and fluorescent polyelectrolytes. Because PMVEMA-Es contains a carboxylic acid group in its structure, the effects of pH and ionic strength on the nanoparticles were also evaluated, finding that the size is responsive to pH and ionic strength, largely swelling at physiological pH and returning to their initial size at acidic pHs. Thus, the developed fluorescent nanoparticles can be categorized as pH-sensitive fluorescent nanogels, since they possess the properties of both pH-responsive hydrogels and nanoparticulate systems. Doxorubicin (DOX) was used as a model drug to show the capacity of the blue-emitting nanogels to hold drugs in acidic media and release them at physiological pH, from changes in the fluorescence properties of both nanoparticles and DOX. In addition, preliminary studies by super-resolution confocal microscopy were performed, regarding their potential use as image probes.
publishDate 2021
dc.date.none.fl_str_mv 2021
2024
2024
dc.type.none.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv https://hdl.handle.net/11000/30576
url https://hdl.handle.net/11000/30576
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv 22(17)
9607
https://doi.org/10.3390/ijms22179607
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
http://creativecommons.org/licenses/by-nc-nd/4.0/
eu_rights_str_mv openAccess
rights_invalid_str_mv http://creativecommons.org/licenses/by-nc-nd/4.0/
dc.format.none.fl_str_mv application/pdf
23
application/pdf
application/pdf
dc.publisher.none.fl_str_mv MDPI
publisher.none.fl_str_mv MDPI
dc.source.none.fl_str_mv reponame:REDIUMH. Depósito Digital de la UMH
instname:Universidad Miguel Hernández de Elche
instname_str Universidad Miguel Hernández de Elche
reponame_str REDIUMH. Depósito Digital de la UMH
collection REDIUMH. Depósito Digital de la UMH
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,300724

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