Peripheral Blood Mononuclear Cells Antioxidant Adaptations to Regular Physical Activity in Elderly People

Regular physical activity prescription is a key point for healthy aging and chronic disease management and prevention. Our aim was to evaluate the antioxidant defense system and the mitochondrial status in peripheral blood mononuclear cells (PBMCs) and the level of oxidative damage in plasma in acti...

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Autores: Busquets-Cortés, Carla, Capó Fiol, Xavier, Bibiloni Esteva, Maria Del Mar, Martorell, Miquel, Ferrer, Miguel D, Argelich, Emma, Bouzas, Cristina, Carreres, Sandra, Tur, Josep A, Pons, Antoni, Soldevila Verdeguer, Carla
Tipo de recurso: artículo
Fecha de publicación:2018
País:España
Institución:Instituto de Salud Carlos III (ISCIII)
Repositorio:Repisalud
Idioma:inglés
OAI Identifier:oai:repisalud.isciii.es:20.500.12105/22583
Acceso en línea:https://hdl.handle.net/20.500.12105/22583
Access Level:acceso abierto
Palabra clave:Active lifestyle
Antioxidants
Daily habits
Elderly
Healthy aging
Mitochondria
PBMCs
ROS
Ejercicio Físico
Femenino
Masculino
Conducta Alimentaria
Envejecimiento
Adaptación Fisiológica
Humanos
Persona de Mediana Edad
Leucocitos Mononucleares
Anciano
Anciano de 80 o más Años
Composición Corporal
Antioxidantes
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spelling Peripheral Blood Mononuclear Cells Antioxidant Adaptations to Regular Physical Activity in Elderly PeopleBusquets-Cortés, CarlaCapó Fiol, XavierBibiloni Esteva, Maria Del MarMartorell, MiquelFerrer, Miguel DArgelich, EmmaBouzas, CristinaCarreres, SandraTur, Josep APons, AntoniSoldevila Verdeguer, CarlaActive lifestyleAntioxidantsDaily habitsElderlyHealthy agingMitochondriaPBMCsROSEjercicio FísicoFemeninoMasculinoConducta AlimentariaEnvejecimientoAdaptación FisiológicaHumanosPersona de Mediana EdadLeucocitos MononuclearesAncianoAnciano de 80 o más AñosComposición CorporalAntioxidantesAntioxidantsRegular physical activity prescription is a key point for healthy aging and chronic disease management and prevention. Our aim was to evaluate the antioxidant defense system and the mitochondrial status in peripheral blood mononuclear cells (PBMCs) and the level of oxidative damage in plasma in active, intermediate and inactive elderly. In total, 127 healthy men and women >55 years old participated in the study and were classified according on their level of declared physical activity. A more active lifestyle was accompanied by lower weight, fat mass and body mass index when compared to a more sedentary life-style. Active participants exhibited lower circulating PBMCs than inactive peers. Participants who reported higher levels of exercise had increased antioxidant protein levels when compared to more sedentary partakers. Carbonylated protein levels exhibited similar behavior, accompanied by a significant raise in expression of cytochrome c oxidase subunit IV in PBMCs. No significant changes were found in the activities of antioxidant enzymes and in the expression of structural (MitND5) and mitochondrial dynamic-related (PGC1 and Mitofusins1/2.) proteins. Active lifestyle and daily activities exert beneficial effects on body composition and it enhances the antioxidant defenses and oxidative metabolism capabilities in PBMCs from healthy elderly.Multidisciplinary Digital Publishing Institute (MDPI)20242024-09-0620182018-10-0120182018-10-01research articlehttp://purl.org/coar/resource_type/c_2df8fbb1info:eu-repo/semantics/articlehttps://hdl.handle.net/20.500.12105/22583reponame:Repisaludinstname:Instituto de Salud Carlos III (ISCIII)Inglésengopen accesshttp://purl.org/coar/access_right/c_abf2Attribution 4.0 Internationalhttp://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:repisalud.isciii.es:20.500.12105/225832026-06-12T12:43:37Z
dc.title.none.fl_str_mv Peripheral Blood Mononuclear Cells Antioxidant Adaptations to Regular Physical Activity in Elderly People
title Peripheral Blood Mononuclear Cells Antioxidant Adaptations to Regular Physical Activity in Elderly People
spellingShingle Peripheral Blood Mononuclear Cells Antioxidant Adaptations to Regular Physical Activity in Elderly People
Busquets-Cortés, Carla
Active lifestyle
Antioxidants
Daily habits
Elderly
Healthy aging
Mitochondria
PBMCs
ROS
Ejercicio Físico
Femenino
Masculino
Conducta Alimentaria
Envejecimiento
Adaptación Fisiológica
Humanos
Persona de Mediana Edad
Leucocitos Mononucleares
Anciano
Anciano de 80 o más Años
Composición Corporal
Antioxidantes
Antioxidants
title_short Peripheral Blood Mononuclear Cells Antioxidant Adaptations to Regular Physical Activity in Elderly People
title_full Peripheral Blood Mononuclear Cells Antioxidant Adaptations to Regular Physical Activity in Elderly People
title_fullStr Peripheral Blood Mononuclear Cells Antioxidant Adaptations to Regular Physical Activity in Elderly People
title_full_unstemmed Peripheral Blood Mononuclear Cells Antioxidant Adaptations to Regular Physical Activity in Elderly People
title_sort Peripheral Blood Mononuclear Cells Antioxidant Adaptations to Regular Physical Activity in Elderly People
dc.creator.none.fl_str_mv Busquets-Cortés, Carla
Capó Fiol, Xavier
Bibiloni Esteva, Maria Del Mar
Martorell, Miquel
Ferrer, Miguel D
Argelich, Emma
Bouzas, Cristina
Carreres, Sandra
Tur, Josep A
Pons, Antoni
Soldevila Verdeguer, Carla
author Busquets-Cortés, Carla
author_facet Busquets-Cortés, Carla
Capó Fiol, Xavier
Bibiloni Esteva, Maria Del Mar
Martorell, Miquel
Ferrer, Miguel D
Argelich, Emma
Bouzas, Cristina
Carreres, Sandra
Tur, Josep A
Pons, Antoni
Soldevila Verdeguer, Carla
author_role author
author2 Capó Fiol, Xavier
Bibiloni Esteva, Maria Del Mar
Martorell, Miquel
Ferrer, Miguel D
Argelich, Emma
Bouzas, Cristina
Carreres, Sandra
Tur, Josep A
Pons, Antoni
Soldevila Verdeguer, Carla
author2_role author
author
author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv
dc.subject.none.fl_str_mv Active lifestyle
Antioxidants
Daily habits
Elderly
Healthy aging
Mitochondria
PBMCs
ROS
Ejercicio Físico
Femenino
Masculino
Conducta Alimentaria
Envejecimiento
Adaptación Fisiológica
Humanos
Persona de Mediana Edad
Leucocitos Mononucleares
Anciano
Anciano de 80 o más Años
Composición Corporal
Antioxidantes
Antioxidants
topic Active lifestyle
Antioxidants
Daily habits
Elderly
Healthy aging
Mitochondria
PBMCs
ROS
Ejercicio Físico
Femenino
Masculino
Conducta Alimentaria
Envejecimiento
Adaptación Fisiológica
Humanos
Persona de Mediana Edad
Leucocitos Mononucleares
Anciano
Anciano de 80 o más Años
Composición Corporal
Antioxidantes
Antioxidants
description Regular physical activity prescription is a key point for healthy aging and chronic disease management and prevention. Our aim was to evaluate the antioxidant defense system and the mitochondrial status in peripheral blood mononuclear cells (PBMCs) and the level of oxidative damage in plasma in active, intermediate and inactive elderly. In total, 127 healthy men and women >55 years old participated in the study and were classified according on their level of declared physical activity. A more active lifestyle was accompanied by lower weight, fat mass and body mass index when compared to a more sedentary life-style. Active participants exhibited lower circulating PBMCs than inactive peers. Participants who reported higher levels of exercise had increased antioxidant protein levels when compared to more sedentary partakers. Carbonylated protein levels exhibited similar behavior, accompanied by a significant raise in expression of cytochrome c oxidase subunit IV in PBMCs. No significant changes were found in the activities of antioxidant enzymes and in the expression of structural (MitND5) and mitochondrial dynamic-related (PGC1 and Mitofusins1/2.) proteins. Active lifestyle and daily activities exert beneficial effects on body composition and it enhances the antioxidant defenses and oxidative metabolism capabilities in PBMCs from healthy elderly.
publishDate 2018
dc.date.none.fl_str_mv 2018
2018-10-01
2018
2018-10-01
2024
2024-09-06
dc.type.none.fl_str_mv research article
http://purl.org/coar/resource_type/c_2df8fbb1
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv https://hdl.handle.net/20.500.12105/22583
url https://hdl.handle.net/20.500.12105/22583
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
Attribution 4.0 International
http://creativecommons.org/licenses/by/4.0/
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
Attribution 4.0 International
http://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Multidisciplinary Digital Publishing Institute (MDPI)
publisher.none.fl_str_mv Multidisciplinary Digital Publishing Institute (MDPI)
dc.source.none.fl_str_mv reponame:Repisalud
instname:Instituto de Salud Carlos III (ISCIII)
instname_str Instituto de Salud Carlos III (ISCIII)
reponame_str Repisalud
collection Repisalud
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,811543

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