Estimating the Prevalence of Cardiac Amyloidosis in Old Patients with Heart Failure—Barriers and Opportunities for Improvement: The PREVAMIC Study

Background: Cardiac amyloidosis (CA) could be a common cause of heart failure (HF). The objective of the study was to estimate the prevalence of CA in patients with HF. Methods: Observational, prospective, and multicenter study involving 30 Spanish hospitals. A total of 453 patients >= 65 years w...

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Autores: Ruiz Hueso, Rocío, Salamanca Bautista, Prado, Quesada Simón, Maria Angustias, Yun, Sergi, Conde Martel, Alicia, Morales Rull, José Luis, Suárez Gil, Roi, García García, José Ángel, Llàcer, Pau, Fonseca Aizpuru, Eva María, Amores Arriaga, Beatriz, Martínez González, Ángel, Armengou Arxe, Arola, Peña Somovilla, José Luis, López Reboiro, Manuel Lorenzo, Aramburu Bodas, Óscar, PREVAMIC Investigators Group
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2023
País:España
Institución:Universidad de Barcelona
Repositorio:Dipòsit Digital de la UB
OAI Identifier:oai:diposit.ub.edu:2445/200879
Acceso en línea:https://hdl.handle.net/2445/200879
Access Level:acceso abierto
Palabra clave:Amiloïdosi
Insuficiència cardíaca
Epidemiologia
Amyloidosis
Heart failure
Epidemiology
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spelling Estimating the Prevalence of Cardiac Amyloidosis in Old Patients with Heart Failure—Barriers and Opportunities for Improvement: The PREVAMIC StudyRuiz Hueso, RocíoSalamanca Bautista, PradoQuesada Simón, Maria AngustiasYun, SergiConde Martel, AliciaMorales Rull, José LuisSuárez Gil, RoiGarcía García, José ÁngelLlàcer, PauFonseca Aizpuru, Eva MaríaAmores Arriaga, BeatrizMartínez González, ÁngelArmengou Arxe, ArolaPeña Somovilla, José LuisLópez Reboiro, Manuel LorenzoAramburu Bodas, ÓscarPREVAMIC Investigators GroupAmiloïdosiInsuficiència cardíacaEpidemiologiaAmyloidosisHeart failureEpidemiologyBackground: Cardiac amyloidosis (CA) could be a common cause of heart failure (HF). The objective of the study was to estimate the prevalence of CA in patients with HF. Methods: Observational, prospective, and multicenter study involving 30 Spanish hospitals. A total of 453 patients >= 65 years with HF and an interventricular septum or posterior wall thickness > 12 mm were included. All patients underwent a Tc-99m-DPD/PYP/HMDP scintigraphy and monoclonal bands were studied, following the current criteria for non-invasive diagnosis. In inconclusive cases, biopsies were performed. Results: The vast majority of CA were diagnosed non-invasively. The prevalence was 20.1%. Most of the CA were transthyretin (ATTR-CM, 84.6%), with a minority of cardiac light-chain amyloidosis (AL-CM, 2.2%). The remaining (13.2%) was untyped. The prevalence was significantly higher in men (60.1% vs 39.9%, p = 0.019). Of the patients with CA, 26.5% had a left ventricular ejection fraction less than 50%. Conclusions: CA was the cause of HF in one out of five patients and should be screened in the elderly with HF and myocardial thickening, regardless of sex and LVEF. Few transthyretin-gene-sequencing studies were performed in older patients. In many patients, it was not possible to determine the amyloid subtype.MDPI AG2023info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://hdl.handle.net/2445/200879Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))reponame:Dipòsit Digital de la UBinstname:Universidad de BarcelonaInglésReproducció del document publicat a: https://doi.org/10.3390/jcm12062273Journal of Clinical Medicine, 2023, vol. 12, num. 6, p. 2273https://doi.org/10.3390/jcm12062273cc by (c) Ruiz Hueso, Rocío et al., 2023http://creativecommons.org/licenses/by/3.0/es/info:eu-repo/semantics/openAccessoai:diposit.ub.edu:2445/2008792026-05-27T06:46:51Z
dc.title.none.fl_str_mv Estimating the Prevalence of Cardiac Amyloidosis in Old Patients with Heart Failure—Barriers and Opportunities for Improvement: The PREVAMIC Study
title Estimating the Prevalence of Cardiac Amyloidosis in Old Patients with Heart Failure—Barriers and Opportunities for Improvement: The PREVAMIC Study
spellingShingle Estimating the Prevalence of Cardiac Amyloidosis in Old Patients with Heart Failure—Barriers and Opportunities for Improvement: The PREVAMIC Study
Ruiz Hueso, Rocío
Amiloïdosi
Insuficiència cardíaca
Epidemiologia
Amyloidosis
Heart failure
Epidemiology
title_short Estimating the Prevalence of Cardiac Amyloidosis in Old Patients with Heart Failure—Barriers and Opportunities for Improvement: The PREVAMIC Study
title_full Estimating the Prevalence of Cardiac Amyloidosis in Old Patients with Heart Failure—Barriers and Opportunities for Improvement: The PREVAMIC Study
title_fullStr Estimating the Prevalence of Cardiac Amyloidosis in Old Patients with Heart Failure—Barriers and Opportunities for Improvement: The PREVAMIC Study
title_full_unstemmed Estimating the Prevalence of Cardiac Amyloidosis in Old Patients with Heart Failure—Barriers and Opportunities for Improvement: The PREVAMIC Study
title_sort Estimating the Prevalence of Cardiac Amyloidosis in Old Patients with Heart Failure—Barriers and Opportunities for Improvement: The PREVAMIC Study
dc.creator.none.fl_str_mv Ruiz Hueso, Rocío
Salamanca Bautista, Prado
Quesada Simón, Maria Angustias
Yun, Sergi
Conde Martel, Alicia
Morales Rull, José Luis
Suárez Gil, Roi
García García, José Ángel
Llàcer, Pau
Fonseca Aizpuru, Eva María
Amores Arriaga, Beatriz
Martínez González, Ángel
Armengou Arxe, Arola
Peña Somovilla, José Luis
López Reboiro, Manuel Lorenzo
Aramburu Bodas, Óscar
PREVAMIC Investigators Group
author Ruiz Hueso, Rocío
author_facet Ruiz Hueso, Rocío
Salamanca Bautista, Prado
Quesada Simón, Maria Angustias
Yun, Sergi
Conde Martel, Alicia
Morales Rull, José Luis
Suárez Gil, Roi
García García, José Ángel
Llàcer, Pau
Fonseca Aizpuru, Eva María
Amores Arriaga, Beatriz
Martínez González, Ángel
Armengou Arxe, Arola
Peña Somovilla, José Luis
López Reboiro, Manuel Lorenzo
Aramburu Bodas, Óscar
PREVAMIC Investigators Group
author_role author
author2 Salamanca Bautista, Prado
Quesada Simón, Maria Angustias
Yun, Sergi
Conde Martel, Alicia
Morales Rull, José Luis
Suárez Gil, Roi
García García, José Ángel
Llàcer, Pau
Fonseca Aizpuru, Eva María
Amores Arriaga, Beatriz
Martínez González, Ángel
Armengou Arxe, Arola
Peña Somovilla, José Luis
López Reboiro, Manuel Lorenzo
Aramburu Bodas, Óscar
PREVAMIC Investigators Group
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Amiloïdosi
Insuficiència cardíaca
Epidemiologia
Amyloidosis
Heart failure
Epidemiology
topic Amiloïdosi
Insuficiència cardíaca
Epidemiologia
Amyloidosis
Heart failure
Epidemiology
description Background: Cardiac amyloidosis (CA) could be a common cause of heart failure (HF). The objective of the study was to estimate the prevalence of CA in patients with HF. Methods: Observational, prospective, and multicenter study involving 30 Spanish hospitals. A total of 453 patients >= 65 years with HF and an interventricular septum or posterior wall thickness > 12 mm were included. All patients underwent a Tc-99m-DPD/PYP/HMDP scintigraphy and monoclonal bands were studied, following the current criteria for non-invasive diagnosis. In inconclusive cases, biopsies were performed. Results: The vast majority of CA were diagnosed non-invasively. The prevalence was 20.1%. Most of the CA were transthyretin (ATTR-CM, 84.6%), with a minority of cardiac light-chain amyloidosis (AL-CM, 2.2%). The remaining (13.2%) was untyped. The prevalence was significantly higher in men (60.1% vs 39.9%, p = 0.019). Of the patients with CA, 26.5% had a left ventricular ejection fraction less than 50%. Conclusions: CA was the cause of HF in one out of five patients and should be screened in the elderly with HF and myocardial thickening, regardless of sex and LVEF. Few transthyretin-gene-sequencing studies were performed in older patients. In many patients, it was not possible to determine the amyloid subtype.
publishDate 2023
dc.date.none.fl_str_mv 2023
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/2445/200879
url https://hdl.handle.net/2445/200879
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Reproducció del document publicat a: https://doi.org/10.3390/jcm12062273
Journal of Clinical Medicine, 2023, vol. 12, num. 6, p. 2273
https://doi.org/10.3390/jcm12062273
dc.rights.none.fl_str_mv cc by (c) Ruiz Hueso, Rocío et al., 2023
http://creativecommons.org/licenses/by/3.0/es/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv cc by (c) Ruiz Hueso, Rocío et al., 2023
http://creativecommons.org/licenses/by/3.0/es/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv MDPI AG
publisher.none.fl_str_mv MDPI AG
dc.source.none.fl_str_mv Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))
reponame:Dipòsit Digital de la UB
instname:Universidad de Barcelona
instname_str Universidad de Barcelona
reponame_str Dipòsit Digital de la UB
collection Dipòsit Digital de la UB
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,301603

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