Negative schizophrenic symptoms as prefrontal cortex dysfunction: Examination using a task measuring goal neglect

Background: The negative symptoms of schizophrenia have been proposed to reflect prefrontal cortex dysfunc-tion. However, this proposal has not been consistently supported in functional imaging studies, which have also used executive tasks that may not capture key aspects of negative symptoms such a...

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Authors: Fuentes-Claramonte P, Ramiro N, Torres L, Argila-Plaza I, Salgado-Pineda P, Soler-Vidal J, García-León MÁ, Albacete A, Bosque C, Panicalli F, Boix E, Munuera J, Tristany J, Sarró S, Bernardo M, Salvador R, McKenna PJ, Pomarol-Clotet E
Format: article
Status:Published version
Publication Date:2022
Country:España
Institution:Fundació Sant Joan de Déu
Repository:r-FSJD. Repositorio Institucional de Producción Científica de la Fundació Sant Joan de Déu
OAI Identifier:oai:fsjd.fundanetsuite.com:p21884
Online Access:https://fsjd.fundanetsuite.com/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=21884
https://www.sciencedirect.com/science/article/pii/S221315822200184X?via%3Dihub
Access Level:Open access
Keyword:Schizophrenia
Negative symptoms
Frontal lobes
Executive function
fMRI
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spelling Negative schizophrenic symptoms as prefrontal cortex dysfunction: Examination using a task measuring goal neglectFuentes-Claramonte PRamiro NTorres LArgila-Plaza ISalgado-Pineda PSoler-Vidal JGarcía-León MÁAlbacete ABosque CPanicalli FBoix EMunuera JTristany JSarró SBernardo MSalvador RMcKenna PJPomarol-Clotet ESchizophreniaNegative symptomsFrontal lobesExecutive functionfMRIBackground: The negative symptoms of schizophrenia have been proposed to reflect prefrontal cortex dysfunc-tion. However, this proposal has not been consistently supported in functional imaging studies, which have also used executive tasks that may not capture key aspects of negative symptoms such as lack of volition.Method: Twenty-four DSM-5 schizophrenic patients with high negative symptoms (HNS), 25 with absent negative symptoms (ANS) and 30 healthy controls underwent fMRI during performance of the Computerized Multiple Elements Test (CMET), a task designed to measure poor organization of goal directed behaviour or 'goal neglect'. Negative symptoms were rated using the PANSS and the Clinical Assessment Interview for Negative Symptoms (CAINS).Results: On whole brain analysis, the ANS patients showed no significant clusters of reduced activation compared to the healthy controls. In contrast, the HNS patients showed hypoactivation compared to the healthy controls in the left anterior frontal cortex, the right dorsolateral prefrontal cortex (DLPFC), the anterior insula bilaterally and the bilateral inferior parietal cortex. When compared to the ANS patients, the HNS patients showed reduced activation in the left anterior frontal cortex, the left DLPFC and the left inferior parietal cortex. After controlling for disorganization scores, differences remained in clusters in the left anterior frontal cortex and the bilateral inferior parietal cortex.Conclusions: This study provides evidence that reduced prefrontal activation, perhaps especially in the left anterior frontal cortex, is a brain functional correlate of negative symptoms in schizophrenia. The simultaneous finding of reduced inferior parietal cortex activation was unexpected, but could reflect this region's involvement in cognitive control, particularly the 'regulative' component of this.ELSEVIER SCI LTD2022info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttps://fsjd.fundanetsuite.com/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=21884https://www.sciencedirect.com/science/article/pii/S221315822200184X?via%3DihubNeuroImage-ClinicalISSN: 22131582reponame:r-FSJD. Repositorio Institucional de Producción Científica de la Fundació Sant Joan de Déuinstname:Fundació Sant Joan de DéuInglésinfo:eu-repo/semantics/openAccessoai:fsjd.fundanetsuite.com:p218842026-05-27T12:37:41Z
dc.title.none.fl_str_mv Negative schizophrenic symptoms as prefrontal cortex dysfunction: Examination using a task measuring goal neglect
title Negative schizophrenic symptoms as prefrontal cortex dysfunction: Examination using a task measuring goal neglect
spellingShingle Negative schizophrenic symptoms as prefrontal cortex dysfunction: Examination using a task measuring goal neglect
Fuentes-Claramonte P
Schizophrenia
Negative symptoms
Frontal lobes
Executive function
fMRI
title_short Negative schizophrenic symptoms as prefrontal cortex dysfunction: Examination using a task measuring goal neglect
title_full Negative schizophrenic symptoms as prefrontal cortex dysfunction: Examination using a task measuring goal neglect
title_fullStr Negative schizophrenic symptoms as prefrontal cortex dysfunction: Examination using a task measuring goal neglect
title_full_unstemmed Negative schizophrenic symptoms as prefrontal cortex dysfunction: Examination using a task measuring goal neglect
title_sort Negative schizophrenic symptoms as prefrontal cortex dysfunction: Examination using a task measuring goal neglect
dc.creator.none.fl_str_mv Fuentes-Claramonte P
Ramiro N
Torres L
Argila-Plaza I
Salgado-Pineda P
Soler-Vidal J
García-León MÁ
Albacete A
Bosque C
Panicalli F
Boix E
Munuera J
Tristany J
Sarró S
Bernardo M
Salvador R
McKenna PJ
Pomarol-Clotet E
author Fuentes-Claramonte P
author_facet Fuentes-Claramonte P
Ramiro N
Torres L
Argila-Plaza I
Salgado-Pineda P
Soler-Vidal J
García-León MÁ
Albacete A
Bosque C
Panicalli F
Boix E
Munuera J
Tristany J
Sarró S
Bernardo M
Salvador R
McKenna PJ
Pomarol-Clotet E
author_role author
author2 Ramiro N
Torres L
Argila-Plaza I
Salgado-Pineda P
Soler-Vidal J
García-León MÁ
Albacete A
Bosque C
Panicalli F
Boix E
Munuera J
Tristany J
Sarró S
Bernardo M
Salvador R
McKenna PJ
Pomarol-Clotet E
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Schizophrenia
Negative symptoms
Frontal lobes
Executive function
fMRI
topic Schizophrenia
Negative symptoms
Frontal lobes
Executive function
fMRI
description Background: The negative symptoms of schizophrenia have been proposed to reflect prefrontal cortex dysfunc-tion. However, this proposal has not been consistently supported in functional imaging studies, which have also used executive tasks that may not capture key aspects of negative symptoms such as lack of volition.Method: Twenty-four DSM-5 schizophrenic patients with high negative symptoms (HNS), 25 with absent negative symptoms (ANS) and 30 healthy controls underwent fMRI during performance of the Computerized Multiple Elements Test (CMET), a task designed to measure poor organization of goal directed behaviour or 'goal neglect'. Negative symptoms were rated using the PANSS and the Clinical Assessment Interview for Negative Symptoms (CAINS).Results: On whole brain analysis, the ANS patients showed no significant clusters of reduced activation compared to the healthy controls. In contrast, the HNS patients showed hypoactivation compared to the healthy controls in the left anterior frontal cortex, the right dorsolateral prefrontal cortex (DLPFC), the anterior insula bilaterally and the bilateral inferior parietal cortex. When compared to the ANS patients, the HNS patients showed reduced activation in the left anterior frontal cortex, the left DLPFC and the left inferior parietal cortex. After controlling for disorganization scores, differences remained in clusters in the left anterior frontal cortex and the bilateral inferior parietal cortex.Conclusions: This study provides evidence that reduced prefrontal activation, perhaps especially in the left anterior frontal cortex, is a brain functional correlate of negative symptoms in schizophrenia. The simultaneous finding of reduced inferior parietal cortex activation was unexpected, but could reflect this region's involvement in cognitive control, particularly the 'regulative' component of this.
publishDate 2022
dc.date.none.fl_str_mv 2022
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://fsjd.fundanetsuite.com/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=21884
https://www.sciencedirect.com/science/article/pii/S221315822200184X?via%3Dihub
url https://fsjd.fundanetsuite.com/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=21884
https://www.sciencedirect.com/science/article/pii/S221315822200184X?via%3Dihub
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv ELSEVIER SCI LTD
publisher.none.fl_str_mv ELSEVIER SCI LTD
dc.source.none.fl_str_mv NeuroImage-Clinical
ISSN: 22131582
reponame:r-FSJD. Repositorio Institucional de Producción Científica de la Fundació Sant Joan de Déu
instname:Fundació Sant Joan de Déu
instname_str Fundació Sant Joan de Déu
reponame_str r-FSJD. Repositorio Institucional de Producción Científica de la Fundació Sant Joan de Déu
collection r-FSJD. Repositorio Institucional de Producción Científica de la Fundació Sant Joan de Déu
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,81155

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