Contact repulsion controls the dispersion and final distribution of Cajal-Retzius cells

Cajal-Retzius (CR) cells play a fundamental role in the development of the mammalian cerebral cortex. They control the formation of cortical layers by regulating the migration of pyramidal cells through the release of Reelin. The function of CR cells critically depends on their regular distribution...

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Autores: Villar-Cerviño, Verona, Molano-Mazón, Manuel, Catchpole, Timothy, Valdeolmillos, Miguel, Henkemeyer, Mark, Martínez, Luis M., Borrell, Víctor, Marín Parra, Óscar
Tipo de documento: artigo
Estado:Versão publicada
Data de publicação:2013
País:España
Recursos:Consejo Superior de Investigaciones Científicas (CSIC)
Repositório:DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:oai:digital.csic.es:10261/289272
Acesso em linha:http://hdl.handle.net/10261/289272
Access Level:Acceso aberto
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spelling Contact repulsion controls the dispersion and final distribution of Cajal-Retzius cellsVillar-Cerviño, VeronaMolano-Mazón, ManuelCatchpole, TimothyValdeolmillos, MiguelHenkemeyer, MarkMartínez, Luis M.Borrell, VíctorMarín Parra, ÓscarCajal-Retzius (CR) cells play a fundamental role in the development of the mammalian cerebral cortex. They control the formation of cortical layers by regulating the migration of pyramidal cells through the release of Reelin. The function of CR cells critically depends on their regular distribution throughout the surface of the cortex, but little is known about the events controlling this phenomenon. Using time-lapse video microscopy in vivo and in vitro, we found that movement of CR cells is regulated by repulsive interactions, which leads to their random dispersion throughout the cortical surface. Mathematical modeling reveals that contact repulsion is both necessary and sufficient for this process, which demonstrates that complex neuronal assemblies may emerge during development through stochastic events. At the molecular level, we found that contact repulsion is mediated by Eph/ephrin interactions. Our observations reveal a mechanism that controls the even distribution of neurons in the developing brain.This work was supported by grants from Spanish Ministry of Science and Innovation SAF2011-28845 and CONSOLIDER CSD2007-00023 to O.M. and from the National Institutes of Health (R01 MH66332) to M.H. V.V.-C. was a “Junta de Ampliación de Estudios” (JAE) postdoctoral fellow from the Consejo Superior de Investigaciones Científicas and is now a “Juan de la Cierva” postdoctoral fellow from the Ministerio de Economía e Innovación.Peer reviewedElsevierMinisterio de Ciencia e Innovación (España)National Institutes of Health (US)Consejo Superior de Investigaciones Científicas (España)Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]202320232013info:eu-repo/semantics/articlehttp://purl.org/coar/resource_type/c_6501Publisher's versioninfo:eu-repo/semantics/publishedVersionapplication/pdfhttp://hdl.handle.net/10261/289272reponame:DIGITAL.CSIC. Repositorio Institucional del CSICinstname:Consejo Superior de Investigaciones Científicas (CSIC)Inglés#PLACEHOLDER_PARENT_METADATA_VALUE##PLACEHOLDER_PARENT_METADATA_VALUE#info:eu-repo/grantAgreement/MICINN//SAF2011-28845info:eu-repo/grantAgreement/MEC//CSD2007-00023Neuronhttps://doi.org/10.1016/j.neuron.2012.11.023Síinfo:eu-repo/semantics/openAccessoai:digital.csic.es:10261/2892722026-05-22T06:33:51Z
dc.title.none.fl_str_mv Contact repulsion controls the dispersion and final distribution of Cajal-Retzius cells
title Contact repulsion controls the dispersion and final distribution of Cajal-Retzius cells
spellingShingle Contact repulsion controls the dispersion and final distribution of Cajal-Retzius cells
Villar-Cerviño, Verona
title_short Contact repulsion controls the dispersion and final distribution of Cajal-Retzius cells
title_full Contact repulsion controls the dispersion and final distribution of Cajal-Retzius cells
title_fullStr Contact repulsion controls the dispersion and final distribution of Cajal-Retzius cells
title_full_unstemmed Contact repulsion controls the dispersion and final distribution of Cajal-Retzius cells
title_sort Contact repulsion controls the dispersion and final distribution of Cajal-Retzius cells
dc.creator.none.fl_str_mv Villar-Cerviño, Verona
Molano-Mazón, Manuel
Catchpole, Timothy
Valdeolmillos, Miguel
Henkemeyer, Mark
Martínez, Luis M.
Borrell, Víctor
Marín Parra, Óscar
author Villar-Cerviño, Verona
author_facet Villar-Cerviño, Verona
Molano-Mazón, Manuel
Catchpole, Timothy
Valdeolmillos, Miguel
Henkemeyer, Mark
Martínez, Luis M.
Borrell, Víctor
Marín Parra, Óscar
author_role author
author2 Molano-Mazón, Manuel
Catchpole, Timothy
Valdeolmillos, Miguel
Henkemeyer, Mark
Martínez, Luis M.
Borrell, Víctor
Marín Parra, Óscar
author2_role author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Ministerio de Ciencia e Innovación (España)
National Institutes of Health (US)
Consejo Superior de Investigaciones Científicas (España)
Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]
description Cajal-Retzius (CR) cells play a fundamental role in the development of the mammalian cerebral cortex. They control the formation of cortical layers by regulating the migration of pyramidal cells through the release of Reelin. The function of CR cells critically depends on their regular distribution throughout the surface of the cortex, but little is known about the events controlling this phenomenon. Using time-lapse video microscopy in vivo and in vitro, we found that movement of CR cells is regulated by repulsive interactions, which leads to their random dispersion throughout the cortical surface. Mathematical modeling reveals that contact repulsion is both necessary and sufficient for this process, which demonstrates that complex neuronal assemblies may emerge during development through stochastic events. At the molecular level, we found that contact repulsion is mediated by Eph/ephrin interactions. Our observations reveal a mechanism that controls the even distribution of neurons in the developing brain.
publishDate 2013
dc.date.none.fl_str_mv 2013
2023
2023
dc.type.none.fl_str_mv info:eu-repo/semantics/article
http://purl.org/coar/resource_type/c_6501
Publisher's version
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10261/289272
url http://hdl.handle.net/10261/289272
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv #PLACEHOLDER_PARENT_METADATA_VALUE#
#PLACEHOLDER_PARENT_METADATA_VALUE#
info:eu-repo/grantAgreement/MICINN//SAF2011-28845
info:eu-repo/grantAgreement/MEC//CSD2007-00023
Neuron
https://doi.org/10.1016/j.neuron.2012.11.023
Sí
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:DIGITAL.CSIC. Repositorio Institucional del CSIC
instname:Consejo Superior de Investigaciones Científicas (CSIC)
instname_str Consejo Superior de Investigaciones Científicas (CSIC)
reponame_str DIGITAL.CSIC. Repositorio Institucional del CSIC
collection DIGITAL.CSIC. Repositorio Institucional del CSIC
repository.name.fl_str_mv
repository.mail.fl_str_mv
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