Impact of brief maternal separation on rodent models of anergia induced by dopamine depletion: analysis in mice of both sexes during adulthood
Mesolimbic dopamine (DA) regulates activation and effort in motivated behaviors. Impairments in DA function induce motivational symptoms such as anergia and fatigue seen in depression. Stress modulates DA depending on its duration and intensity. Early-life events such as maternal separation (MS) cou...
| Autores: | , , , , |
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| Tipo de recurso: | conjunto de datos |
| Fecha de publicación: | 2024 |
| País: | España |
| Institución: | Universitat Jaume I (UJI) |
| Repositorio: | Repositori Universitat Jaume I |
| Idioma: | inglés |
| OAI Identifier: | oai:repositori.uji.es:10234/208428 |
| Acceso en línea: | http://hdl.handle.net/10234/208428 |
| Access Level: | acceso abierto |
| Palabra clave: | early-life stress maternal separation dopamine behavioral activation sex differences |
| Sumario: | Mesolimbic dopamine (DA) regulates activation and effort in motivated behaviors. Impairments in DA function induce motivational symptoms such as anergia and fatigue seen in depression. Stress modulates DA depending on its duration and intensity. Early-life events such as maternal separation (MS) could act as a stressor, affecting brain development and leading to behavioral changes later in life. However, little is known about the effect of early-life stressors on adult effort-based decision-making. CD1 male and female mice were subjected to early-mild MS (PND3-5, 90 min/day), and, during adulthood, were evaluated on selection of effortful responses under positive or aversive experimental conditions. The choice to engage in effortful activities such as running in a wheel (RW) versus engaging with passive reinforcers was evaluated in a three-choice-T-maze task. In the forced swim task (FST), time dedicated to vigorously escaping versus passively floating was measured. MS mice of both sexes, spent more time in the RW, and climbing in the FST, showing an increase in relative preferences for activity-based reinforcers, and persistence in vigorous escaping from aversive contexts compared to non-separated mice. Separated animals were less anxious but males were less socially oriented. DA depletion induced anergia in males, and increased the neurotrophic factor CDNF in Nacb of both sexes independently of separation conditions. Measures of anxiety, social interaction and sucrose preference and consumption were not affected after DA depletion. Thus, mild-early MS potentiates effortful behaviors during adulthood independently of the emotional value of the situation. Males were more vulnerable to DA-depletion induced-anergia. |
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