Short-term exposure to environmental levels of nicotine and cotinine impairs visual motor response in zebrafish larvae through a similar mode of action: Exploring the potential role of zebrafish α7 nAChR

The current view is that environmental levels of nicotine and cotinine, commonly in the ng/L range, are safe for aquatic organisms. In this study, 7 days post-fertilization zebrafish embryos have been exposed for 24 h to a range of environmental concentrations of nicotine (2.0 ng/L-2.5 μg/L) and cot...

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Detalhes bibliográficos
Autores: Bellot, Marina, Manen, Leticia, Prats, Eva, Bedrossiantz, Juliette, Barata Martí, Carlos, Gómez-Canela, Cristian, Antolin, Albert A., Raldúa, Demetrio
Tipo de documento: artigo
Estado:Versión aceptada para publicación
Data de publicação:2024
País:España
Recursos:Consejo Superior de Investigaciones Científicas (CSIC)
Repositório:DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:oai:digital.csic.es:10261/341796
Acesso em linha:http://hdl.handle.net/10261/341796
https://api.elsevier.com/content/abstract/scopus_id/85179891632
Access Level:Acceso aberto
Palavra-chave:Nicotinic acetylcholine receptor
Behavior
Cotinine
Fish larvae
Nicotine
http://metadata.un.org/sdg/3
Ensure healthy lives and promote well-being for all at all ages
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spelling Short-term exposure to environmental levels of nicotine and cotinine impairs visual motor response in zebrafish larvae through a similar mode of action: Exploring the potential role of zebrafish α7 nAChRBellot, MarinaManen, LeticiaPrats, EvaBedrossiantz, JulietteBarata Martí, CarlosGómez-Canela, CristianAntolin, Albert A.Raldúa, DemetrioNicotinic acetylcholine receptorBehaviorCotinineFish larvaeNicotinehttp://metadata.un.org/sdg/3Ensure healthy lives and promote well-being for all at all agesThe current view is that environmental levels of nicotine and cotinine, commonly in the ng/L range, are safe for aquatic organisms. In this study, 7 days post-fertilization zebrafish embryos have been exposed for 24 h to a range of environmental concentrations of nicotine (2.0 ng/L-2.5 μg/L) and cotinine (50 pg/L–10 μg/L), as well as to a binary mixture of these emerging pollutants. Nicotine exposure led to hyperactivity, decreased vibrational startle response and increased non-associative learning. However, the more consistent effect found for both nicotine and cotinine was a significant increase in light-off visual motor response (VMR). The effect of both pollutants on this behavior occurred through a similar mode of action, as the joint effects of the binary mixture of both chemicals were consistent with the concentration addition concept predictions. The results from docking studies suggest that the effect of nicotine and cotinine on light-off VMR could be mediated by zebrafish α7 nAChR expressed in retina. The results presented in this study emphasize the need to revisit the environmental risk assessment of chemicals including additional ecologically relevant sublethal endpoints.This work was supported by “Agencia Estatal de Investigación” from the Spanish Ministry of Science and Innovation (projects PID2020-113371RB-C21 and PID2020-113371RB-C22). Juliette Bedrossiantz was supported by a PhD grant (PRE2018-083513) co-financed by the Spanish Government and the European Social Fund (ESF). A.A.A. is an ISCIII–Miguel Servet Fellow supported by the Instituto de Salud Carlos III grant CP23/00115. This work was also supported by the CERCA Program/Generalitat de Catalunya, and FEDER funds/European Regional Development Fund (ERDF) — a way to Build Europe.Peer reviewedElsevierConsejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]202420242024info:eu-repo/semantics/articlehttp://purl.org/coar/resource_type/c_6501Postprintinfo:eu-repo/semantics/acceptedVersionhttp://hdl.handle.net/10261/341796https://api.elsevier.com/content/abstract/scopus_id/85179891632reponame:DIGITAL.CSIC. Repositorio Institucional del CSICinstname:Consejo Superior de Investigaciones Científicas (CSIC)InglésScience of the Total Environmenthttps://doi.org/10.1016/j.scitotenv.2023.169301Síinfo:eu-repo/semantics/openAccessoai:digital.csic.es:10261/3417962026-05-22T06:33:51Z
dc.title.none.fl_str_mv Short-term exposure to environmental levels of nicotine and cotinine impairs visual motor response in zebrafish larvae through a similar mode of action: Exploring the potential role of zebrafish α7 nAChR
title Short-term exposure to environmental levels of nicotine and cotinine impairs visual motor response in zebrafish larvae through a similar mode of action: Exploring the potential role of zebrafish α7 nAChR
spellingShingle Short-term exposure to environmental levels of nicotine and cotinine impairs visual motor response in zebrafish larvae through a similar mode of action: Exploring the potential role of zebrafish α7 nAChR
Bellot, Marina
Nicotinic acetylcholine receptor
Behavior
Cotinine
Fish larvae
Nicotine
http://metadata.un.org/sdg/3
Ensure healthy lives and promote well-being for all at all ages
title_short Short-term exposure to environmental levels of nicotine and cotinine impairs visual motor response in zebrafish larvae through a similar mode of action: Exploring the potential role of zebrafish α7 nAChR
title_full Short-term exposure to environmental levels of nicotine and cotinine impairs visual motor response in zebrafish larvae through a similar mode of action: Exploring the potential role of zebrafish α7 nAChR
title_fullStr Short-term exposure to environmental levels of nicotine and cotinine impairs visual motor response in zebrafish larvae through a similar mode of action: Exploring the potential role of zebrafish α7 nAChR
title_full_unstemmed Short-term exposure to environmental levels of nicotine and cotinine impairs visual motor response in zebrafish larvae through a similar mode of action: Exploring the potential role of zebrafish α7 nAChR
title_sort Short-term exposure to environmental levels of nicotine and cotinine impairs visual motor response in zebrafish larvae through a similar mode of action: Exploring the potential role of zebrafish α7 nAChR
dc.creator.none.fl_str_mv Bellot, Marina
Manen, Leticia
Prats, Eva
Bedrossiantz, Juliette
Barata Martí, Carlos
Gómez-Canela, Cristian
Antolin, Albert A.
Raldúa, Demetrio
author Bellot, Marina
author_facet Bellot, Marina
Manen, Leticia
Prats, Eva
Bedrossiantz, Juliette
Barata Martí, Carlos
Gómez-Canela, Cristian
Antolin, Albert A.
Raldúa, Demetrio
author_role author
author2 Manen, Leticia
Prats, Eva
Bedrossiantz, Juliette
Barata Martí, Carlos
Gómez-Canela, Cristian
Antolin, Albert A.
Raldúa, Demetrio
author2_role author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]
dc.subject.none.fl_str_mv Nicotinic acetylcholine receptor
Behavior
Cotinine
Fish larvae
Nicotine
http://metadata.un.org/sdg/3
Ensure healthy lives and promote well-being for all at all ages
topic Nicotinic acetylcholine receptor
Behavior
Cotinine
Fish larvae
Nicotine
http://metadata.un.org/sdg/3
Ensure healthy lives and promote well-being for all at all ages
description The current view is that environmental levels of nicotine and cotinine, commonly in the ng/L range, are safe for aquatic organisms. In this study, 7 days post-fertilization zebrafish embryos have been exposed for 24 h to a range of environmental concentrations of nicotine (2.0 ng/L-2.5 μg/L) and cotinine (50 pg/L–10 μg/L), as well as to a binary mixture of these emerging pollutants. Nicotine exposure led to hyperactivity, decreased vibrational startle response and increased non-associative learning. However, the more consistent effect found for both nicotine and cotinine was a significant increase in light-off visual motor response (VMR). The effect of both pollutants on this behavior occurred through a similar mode of action, as the joint effects of the binary mixture of both chemicals were consistent with the concentration addition concept predictions. The results from docking studies suggest that the effect of nicotine and cotinine on light-off VMR could be mediated by zebrafish α7 nAChR expressed in retina. The results presented in this study emphasize the need to revisit the environmental risk assessment of chemicals including additional ecologically relevant sublethal endpoints.
publishDate 2024
dc.date.none.fl_str_mv 2024
2024
2024
dc.type.none.fl_str_mv info:eu-repo/semantics/article
http://purl.org/coar/resource_type/c_6501
Postprint
info:eu-repo/semantics/acceptedVersion
format article
status_str acceptedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10261/341796
https://api.elsevier.com/content/abstract/scopus_id/85179891632
url http://hdl.handle.net/10261/341796
https://api.elsevier.com/content/abstract/scopus_id/85179891632
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Science of the Total Environment
https://doi.org/10.1016/j.scitotenv.2023.169301
Sí
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:DIGITAL.CSIC. Repositorio Institucional del CSIC
instname:Consejo Superior de Investigaciones Científicas (CSIC)
instname_str Consejo Superior de Investigaciones Científicas (CSIC)
reponame_str DIGITAL.CSIC. Repositorio Institucional del CSIC
collection DIGITAL.CSIC. Repositorio Institucional del CSIC
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15.811543

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