The gut microbiota and diabetes: research, translation, and clinical applications - 2023 Diabetes, Diabetes Care, and Diabetologia Expert Forum
This article summarises the state of the science on the role of the gut microbiota (GM) in diabetes from a recent international expert forum organised by Diabetes, Diabetes Care, and Diabetologia, which was held at the European Association for the Study of Diabetes 2023 Annual Meeting in Hamburg, Ge...
| Autores: | , , , , , , , , |
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| Formato: | artículo |
| Estado: | Versión publicada |
| Fecha de publicación: | 2024 |
| País: | España |
| Recursos: | Consejo Superior de Investigaciones Científicas (CSIC) |
| Repositorio: | DIGITAL.CSIC. Repositorio Institucional del CSIC |
| OAI Identifier: | oai:digital.csic.es:10261/362011 |
| Acesso em linha: | http://hdl.handle.net/10261/362011 https://api.elsevier.com/content/abstract/scopus_id/85196641458 |
| Access Level: | acceso abierto |
| Palavra-chave: | Butyrate Faecal microbiota transplantation Gastrointestinal microbiota Gastrointestinal tract microbiology Gut microbiota Large intestine microbiota Metagenomics Microbiota metabolites Review Short-chain fatty acids butyrates microbiomes microbiology intestines metagenomics |
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The gut microbiota and diabetes: research, translation, and clinical applications - 2023 Diabetes, Diabetes Care, and Diabetologia Expert Forum |
| title |
The gut microbiota and diabetes: research, translation, and clinical applications - 2023 Diabetes, Diabetes Care, and Diabetologia Expert Forum |
| spellingShingle |
The gut microbiota and diabetes: research, translation, and clinical applications - 2023 Diabetes, Diabetes Care, and Diabetologia Expert Forum Byndloss, Mariana Butyrate Faecal microbiota transplantation Gastrointestinal microbiota Gastrointestinal tract microbiology Gut microbiota Large intestine microbiota Metagenomics Microbiota metabolites Review Short-chain fatty acids butyrates microbiomes microbiology intestines metagenomics |
| title_short |
The gut microbiota and diabetes: research, translation, and clinical applications - 2023 Diabetes, Diabetes Care, and Diabetologia Expert Forum |
| title_full |
The gut microbiota and diabetes: research, translation, and clinical applications - 2023 Diabetes, Diabetes Care, and Diabetologia Expert Forum |
| title_fullStr |
The gut microbiota and diabetes: research, translation, and clinical applications - 2023 Diabetes, Diabetes Care, and Diabetologia Expert Forum |
| title_full_unstemmed |
The gut microbiota and diabetes: research, translation, and clinical applications - 2023 Diabetes, Diabetes Care, and Diabetologia Expert Forum |
| title_sort |
The gut microbiota and diabetes: research, translation, and clinical applications - 2023 Diabetes, Diabetes Care, and Diabetologia Expert Forum |
| dc.creator.none.fl_str_mv |
Byndloss, Mariana Devkota, Suzanne Duca, Frank Niess, Jan Hendrik Nieuwdorp, Max Orho-Melander, Marju Sanz Herranz, Yolanda Tremaroli, Valentina Zhao, Liping |
| author |
Byndloss, Mariana |
| author_facet |
Byndloss, Mariana Devkota, Suzanne Duca, Frank Niess, Jan Hendrik Nieuwdorp, Max Orho-Melander, Marju Sanz Herranz, Yolanda Tremaroli, Valentina Zhao, Liping |
| author_role |
author |
| author2 |
Devkota, Suzanne Duca, Frank Niess, Jan Hendrik Nieuwdorp, Max Orho-Melander, Marju Sanz Herranz, Yolanda Tremaroli, Valentina Zhao, Liping |
| author2_role |
author author author author author author author author |
| dc.contributor.none.fl_str_mv |
Novo Nordisk Foundation National Institute of Diabetes and Digestive and Kidney Diseases (US) The Pew Charitable Trusts Burroughs Wellcome Fund Swiss National Science Foundation Ministerio de Ciencia, Innovación y Universidades (España) Agencia Estatal de Investigación (España) European Commission Byndloss, Mariana [0000-0002-2122-4156] Devkota, Suzanne [0000-0001-5575-9362] Duca, Frank [0000-0003-1760-4081] Niess, Jan Hendrik [0000-0001-6902-5650] Nieuwdorp, Max [0000-0002-1926-7659] Orho-Melander, Marju [0000-0002-3578-2503] Sanz Herranz, Yolanda [0000-0002-1615-1976] Tremaroli, Valentina [0000-0002-9150-4233] Zhao, Liping [0000-0001-9694-7140] Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72] |
| dc.subject.none.fl_str_mv |
Butyrate Faecal microbiota transplantation Gastrointestinal microbiota Gastrointestinal tract microbiology Gut microbiota Large intestine microbiota Metagenomics Microbiota metabolites Review Short-chain fatty acids butyrates microbiomes microbiology intestines metagenomics |
| topic |
Butyrate Faecal microbiota transplantation Gastrointestinal microbiota Gastrointestinal tract microbiology Gut microbiota Large intestine microbiota Metagenomics Microbiota metabolites Review Short-chain fatty acids butyrates microbiomes microbiology intestines metagenomics |
| description |
This article summarises the state of the science on the role of the gut microbiota (GM) in diabetes from a recent international expert forum organised by Diabetes, Diabetes Care, and Diabetologia, which was held at the European Association for the Study of Diabetes 2023 Annual Meeting in Hamburg, Germany. Forum participants included clinicians and basic scientists who are leading investigators in the field of the intestinal microbiome and metabolism. Their conclusions were as follows: (1) the GM may be involved in the pathophysiology of type 2 diabetes, as microbially produced metabolites associate both positively and negatively with the disease, and mechanistic links of GM functions (e.g. genes for butyrate production) with glucose metabolism have recently emerged through the use of Mendelian randomisation in humans; (2) the highly individualised nature of the GM poses a major research obstacle, and large cohorts and a deep-sequencing metagenomic approach are required for robust assessments of associations and causation; (3) because single time point sampling misses intraindividual GM dynamics, future studies with repeated measures within individuals are needed; and (4) much future research will be required to determine the applicability of this expanding knowledge to diabetes diagnosis and treatment, and novel technologies and improved computational tools will be important to achieve this goal. |
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2024 |
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2024 2024 2024 |
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info:eu-repo/semantics/article http://purl.org/coar/resource_type/c_dcae04bc Publisher's version info:eu-repo/semantics/publishedVersion |
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article |
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publishedVersion |
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http://hdl.handle.net/10261/362011 https://api.elsevier.com/content/abstract/scopus_id/85196641458 |
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http://hdl.handle.net/10261/362011 https://api.elsevier.com/content/abstract/scopus_id/85196641458 |
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Inglés |
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The gut microbiota and diabetes: research, translation, and clinical applications - 2023 Diabetes, Diabetes Care, and Diabetologia Expert ForumByndloss, MarianaDevkota, SuzanneDuca, FrankNiess, Jan HendrikNieuwdorp, MaxOrho-Melander, MarjuSanz Herranz, YolandaTremaroli, ValentinaZhao, LipingButyrateFaecal microbiota transplantationGastrointestinal microbiotaGastrointestinal tract microbiologyGut microbiotaLarge intestine microbiotaMetagenomicsMicrobiota metabolitesReviewShort-chain fatty acidsbutyratesmicrobiomesmicrobiologyintestinesmetagenomicsThis article summarises the state of the science on the role of the gut microbiota (GM) in diabetes from a recent international expert forum organised by Diabetes, Diabetes Care, and Diabetologia, which was held at the European Association for the Study of Diabetes 2023 Annual Meeting in Hamburg, Germany. Forum participants included clinicians and basic scientists who are leading investigators in the field of the intestinal microbiome and metabolism. Their conclusions were as follows: (1) the GM may be involved in the pathophysiology of type 2 diabetes, as microbially produced metabolites associate both positively and negatively with the disease, and mechanistic links of GM functions (e.g. genes for butyrate production) with glucose metabolism have recently emerged through the use of Mendelian randomisation in humans; (2) the highly individualised nature of the GM poses a major research obstacle, and large cohorts and a deep-sequencing metagenomic approach are required for robust assessments of associations and causation; (3) because single time point sampling misses intraindividual GM dynamics, future studies with repeated measures within individuals are needed; and (4) much future research will be required to determine the applicability of this expanding knowledge to diabetes diagnosis and treatment, and novel technologies and improved computational tools will be important to achieve this goal.The 2023 Diabetes, Diabetes Care, and Diabetologia expert forum ‘The microbiome and diabetes: research, translation and clinical applications’, including a subsequent symposium presented on this topic and the preparation of this article, was supported by a grant from the Novo Nordisk Foundation (NNF23SA0085453). MB is a Howard Hughes Medical Institute Freeman Hrabowski Scholar and is supported by National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) grant NIDDK R01DK131104, the Pew Charitable Trusts (2022-A-19568), and the Burroughs Wellcome Fund Investigators in the Pathogenesis of Infectious Disease (022792). SD is supported by NIDDK grants NIDDK R01DK123446 and 1DP1 DK130687. JHN is supported by the Swiss National Science Foundation (SNSF) grant 310030_219210. MN is supported by a personal ZONMW-VICI grant 2020 (09150182010020) and a DFN-DON grant 2020 (2020.10.002). YS is supported by grants from the Spanish Ministry of Science, Innovation and Universities MICIU/AEI (PID2020-119536RB-I00) and Severo Ochoa Center of Excellence (ref. CEX2021- 001189-S/10.13039/501100011033). VT is a co-principal investigator of a research project funded by the European Union’s Innovative Medicines Initiative (IMI grant 875534).With funding from the Spanish government through the ‘Severo Ochoa Centre of Excellence’ accreditation (CEX 2021-001189-S)Peer reviewedSpringer NatureNovo Nordisk FoundationNational Institute of Diabetes and Digestive and Kidney Diseases (US)The Pew Charitable TrustsBurroughs Wellcome FundSwiss National Science FoundationMinisterio de Ciencia, Innovación y Universidades (España)Agencia Estatal de Investigación (España)European CommissionByndloss, Mariana [0000-0002-2122-4156]Devkota, Suzanne [0000-0001-5575-9362]Duca, Frank [0000-0003-1760-4081]Niess, Jan Hendrik [0000-0001-6902-5650]Nieuwdorp, Max [0000-0002-1926-7659]Orho-Melander, Marju [0000-0002-3578-2503]Sanz Herranz, Yolanda [0000-0002-1615-1976]Tremaroli, Valentina [0000-0002-9150-4233]Zhao, Liping [0000-0001-9694-7140]Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]202420242024info:eu-repo/semantics/articlehttp://purl.org/coar/resource_type/c_dcae04bcPublisher's versioninfo:eu-repo/semantics/publishedVersionapplication/pdfhttp://hdl.handle.net/10261/362011https://api.elsevier.com/content/abstract/scopus_id/85196641458reponame:DIGITAL.CSIC. Repositorio Institucional del CSICinstname:Consejo Superior de Investigaciones Científicas (CSIC)Inglés#PLACEHOLDER_PARENT_METADATA_VALUE##PLACEHOLDER_PARENT_METADATA_VALUE##PLACEHOLDER_PARENT_METADATA_VALUE#info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2021-2023/CEX 2021-001189-Sinfo:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/PID2020-119536RB-I00info:eu-repo/grantAgreement/EC/H2020/875534Diabetologiahttps://doi.org/10.1007/s00125-024-06198-1Síinfo:eu-repo/semantics/openAccessoai:digital.csic.es:10261/3620112026-05-22T06:33:51Z |
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