Towards novel photodynamic anticancer agents generating superoxide anion radicals: A cyclometalated IrIII complex conjugated to a far-red emitting coumarin

Although cyclometalated IrIII complexes have emerged as promising photosensitizers for photodynamic therapy, some key drawbacks still hamper clinical translation, such as operability in the phototherapeutic window and reactive oxygen species (ROS) production efficiency and selectivity. In this work,...

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Autores: Novohradsky, Vojtech, Rovira, Anna, Hally, Cormac, Galindo Muñoz, Alex, Vigueras, Gloria, Gandioso, Albert, Svitelova, Marie, Bresolí-Obach, Roger, Kostrhunova, Hana, Markova, Lenka, Kasparkova, Jana, Nonell, Santi, Ruiz, José, Brabec, Viktor, Marchán Sancho, Vicente
Tipo de recurso: artículo
Estado:Versión aceptada para publicación
Fecha de publicación:2019
País:España
Institución:Universidad de Barcelona
Repositorio:Dipòsit Digital de la UB
OAI Identifier:oai:diposit.ub.edu:2445/133584
Acceso en línea:https://hdl.handle.net/2445/133584
Access Level:acceso abierto
Palabra clave:Cumarines
Cèl·lules canceroses
Coumarins
Cancer cells
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repository_id_str
spelling Towards novel photodynamic anticancer agents generating superoxide anion radicals: A cyclometalated IrIII complex conjugated to a far-red emitting coumarinNovohradsky, VojtechRovira, AnnaHally, CormacGalindo Muñoz, AlexVigueras, GloriaGandioso, AlbertSvitelova, MarieBresolí-Obach, RogerKostrhunova, HanaMarkova, LenkaKasparkova, JanaNonell, SantiRuiz, JoséBrabec, ViktorMarchán Sancho, VicenteCumarinesCèl·lules cancerosesCoumarinsCancer cellsAlthough cyclometalated IrIII complexes have emerged as promising photosensitizers for photodynamic therapy, some key drawbacks still hamper clinical translation, such as operability in the phototherapeutic window and reactive oxygen species (ROS) production efficiency and selectivity. In this work, a cyclometalated IrIII complex conjugated to a far-red-emitting coumarin, IrIII-COUPY, is reported with highly favourable properties for cancer phototherapy. IrIII-COUPY was efficiently taken up by HeLa cells and showed no dark cytotoxicity and impressive photocytotoxicity indexes after irradiation with green and blue light, even under hypoxia. Importantly, a clear correlation between cell death and intracellular generation of superoxide anion radicals after visible light irradiation was demonstrated. This strategy opens the door to novel fluorescent photodynamic therapy agents with promising applications in theragnosis.Wiley-VCH2019info:eu-repo/semantics/articleinfo:eu-repo/semantics/acceptedVersionapplication/pdfhttps://hdl.handle.net/2445/133584Articles publicats en revistes (Química Inorgànica i Orgànica)reponame:Dipòsit Digital de la UBinstname:Universidad de BarcelonaInglésVersió postprint del document publicat a: https://doi.org/10.1002/anie.201901268Angewandte Chemie-International Edition, 2019, vol. 58, num. 19, p. 6311-6315https://doi.org/10.1002/anie.201901268(c) Wiley-VCH, 2019info:eu-repo/semantics/openAccessoai:diposit.ub.edu:2445/1335842026-05-27T06:46:51Z
dc.title.none.fl_str_mv Towards novel photodynamic anticancer agents generating superoxide anion radicals: A cyclometalated IrIII complex conjugated to a far-red emitting coumarin
title Towards novel photodynamic anticancer agents generating superoxide anion radicals: A cyclometalated IrIII complex conjugated to a far-red emitting coumarin
spellingShingle Towards novel photodynamic anticancer agents generating superoxide anion radicals: A cyclometalated IrIII complex conjugated to a far-red emitting coumarin
Novohradsky, Vojtech
Cumarines
Cèl·lules canceroses
Coumarins
Cancer cells
title_short Towards novel photodynamic anticancer agents generating superoxide anion radicals: A cyclometalated IrIII complex conjugated to a far-red emitting coumarin
title_full Towards novel photodynamic anticancer agents generating superoxide anion radicals: A cyclometalated IrIII complex conjugated to a far-red emitting coumarin
title_fullStr Towards novel photodynamic anticancer agents generating superoxide anion radicals: A cyclometalated IrIII complex conjugated to a far-red emitting coumarin
title_full_unstemmed Towards novel photodynamic anticancer agents generating superoxide anion radicals: A cyclometalated IrIII complex conjugated to a far-red emitting coumarin
title_sort Towards novel photodynamic anticancer agents generating superoxide anion radicals: A cyclometalated IrIII complex conjugated to a far-red emitting coumarin
dc.creator.none.fl_str_mv Novohradsky, Vojtech
Rovira, Anna
Hally, Cormac
Galindo Muñoz, Alex
Vigueras, Gloria
Gandioso, Albert
Svitelova, Marie
Bresolí-Obach, Roger
Kostrhunova, Hana
Markova, Lenka
Kasparkova, Jana
Nonell, Santi
Ruiz, José
Brabec, Viktor
Marchán Sancho, Vicente
author Novohradsky, Vojtech
author_facet Novohradsky, Vojtech
Rovira, Anna
Hally, Cormac
Galindo Muñoz, Alex
Vigueras, Gloria
Gandioso, Albert
Svitelova, Marie
Bresolí-Obach, Roger
Kostrhunova, Hana
Markova, Lenka
Kasparkova, Jana
Nonell, Santi
Ruiz, José
Brabec, Viktor
Marchán Sancho, Vicente
author_role author
author2 Rovira, Anna
Hally, Cormac
Galindo Muñoz, Alex
Vigueras, Gloria
Gandioso, Albert
Svitelova, Marie
Bresolí-Obach, Roger
Kostrhunova, Hana
Markova, Lenka
Kasparkova, Jana
Nonell, Santi
Ruiz, José
Brabec, Viktor
Marchán Sancho, Vicente
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Cumarines
Cèl·lules canceroses
Coumarins
Cancer cells
topic Cumarines
Cèl·lules canceroses
Coumarins
Cancer cells
description Although cyclometalated IrIII complexes have emerged as promising photosensitizers for photodynamic therapy, some key drawbacks still hamper clinical translation, such as operability in the phototherapeutic window and reactive oxygen species (ROS) production efficiency and selectivity. In this work, a cyclometalated IrIII complex conjugated to a far-red-emitting coumarin, IrIII-COUPY, is reported with highly favourable properties for cancer phototherapy. IrIII-COUPY was efficiently taken up by HeLa cells and showed no dark cytotoxicity and impressive photocytotoxicity indexes after irradiation with green and blue light, even under hypoxia. Importantly, a clear correlation between cell death and intracellular generation of superoxide anion radicals after visible light irradiation was demonstrated. This strategy opens the door to novel fluorescent photodynamic therapy agents with promising applications in theragnosis.
publishDate 2019
dc.date.none.fl_str_mv 2019
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/acceptedVersion
format article
status_str acceptedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/2445/133584
url https://hdl.handle.net/2445/133584
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Versió postprint del document publicat a: https://doi.org/10.1002/anie.201901268
Angewandte Chemie-International Edition, 2019, vol. 58, num. 19, p. 6311-6315
https://doi.org/10.1002/anie.201901268
dc.rights.none.fl_str_mv (c) Wiley-VCH, 2019
info:eu-repo/semantics/openAccess
rights_invalid_str_mv (c) Wiley-VCH, 2019
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Wiley-VCH
publisher.none.fl_str_mv Wiley-VCH
dc.source.none.fl_str_mv Articles publicats en revistes (Química Inorgànica i Orgànica)
reponame:Dipòsit Digital de la UB
instname:Universidad de Barcelona
instname_str Universidad de Barcelona
reponame_str Dipòsit Digital de la UB
collection Dipòsit Digital de la UB
repository.name.fl_str_mv
repository.mail.fl_str_mv
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