Hospital Admission Trends in Alpha-1-Antitrypsin Deficiency: A Sex-Based Analysis from the Spanish National Discharge Database, 2016-2022

bjectives: To analyze the number and clinical characteristics of hospital admissions in Spain between 2016 and 2022 in which alpha-1-antitrypsin deficiency (AATD) was coded; to describe and analyze differences in these parameters between men and women; and to identify variables associated with a wor...

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Detalhes bibliográficos
Autores: Miguel Díez, Javier De, López De Andrés, Ana Isabel, Zamorano León, José Javier, Hernández Barrera, Valentín, Cuadrado Corrales, María Natividad, Jiménez Sierra, Ana, Carabantes Alarcón, David, Jiménez García, Rodrigo
Formato: artículo
Fecha de publicación:2024
País:España
Recursos:Universidad Complutense de Madrid (UCM)
Repositorio:Docta Complutense
Idioma:inglés
OAI Identifier:oai:docta.ucm.es:20.500.14352/117898
Acesso em linha:https://hdl.handle.net/20.500.14352/117898
Access Level:acceso abierto
Palavra-chave:Alpha-1 antitrypsin deficiency
Hospital admissions
Comorbidities
In-hospital mortality
Sex-differences
Trends
Ciencias Biomédicas
32 Ciencias Médicas
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spelling Hospital Admission Trends in Alpha-1-Antitrypsin Deficiency: A Sex-Based Analysis from the Spanish National Discharge Database, 2016-2022Miguel Díez, Javier DeLópez De Andrés, Ana IsabelZamorano León, José JavierHernández Barrera, ValentínCuadrado Corrales, María NatividadJiménez Sierra, AnaCarabantes Alarcón, DavidJiménez García, RodrigoAlpha-1 antitrypsin deficiencyHospital admissionsComorbiditiesIn-hospital mortalitySex-differencesTrendsCiencias Biomédicas32 Ciencias Médicasbjectives: To analyze the number and clinical characteristics of hospital admissions in Spain between 2016 and 2022 in which alpha-1-antitrypsin deficiency (AATD) was coded; to describe and analyze differences in these parameters between men and women; and to identify variables associated with a worse prognosis. Methods: We used a nationwide discharge database to select all admissions featuring an AATD diagnostic code (ICD-10 code E88.01) in any position. Results: We found 5142 hospital admissions with a diagnosis of AATD and detected a significant increase in their number from 2016 to 2022 (p = 0.034 for trend). Males accounted for 58.21% of the hospitalizations and had a higher Charlson Comorbidity Index than women (1.86 vs. 1.33; p < 0.001), were hospitalized more frequently (21.18% of men were hospitalized more than once vs. 17.76% of women, p < 0.001), and had a higher probability of severe disease (OR 1.39; 95%CI 1.10-1.75). Crude in-hospital mortality (IHM) was 6.85% in men and 4.8% in women (p = 0.007). The variables associated with IHM in both sexes were older age, more hospital admissions, and liver disease or lung cancer. Invasive and non-invasive mechanical ventilation and admission to the ICU were also associated with IHM in men and women. Multivariable adjustment revealed no association between sex and IHM. Conclusions: The number of hospitalizations for AATD increased in Spain from 2016 to 2022. Men represented almost 60% of hospitalizations, were admitted more frequently and with more comorbidities, and had a higher probability of severe disease than women. There was no association between sex and IHM.MDPIUniversidad Complutense de Madrid20242024-09-2220242024-09-22journal articlehttp://purl.org/coar/resource_type/c_6501info:eu-repo/semantics/articleapplication/pdfhttps://hdl.handle.net/20.500.14352/117898reponame:Docta Complutenseinstname:Universidad Complutense de Madrid (UCM)Inglésengopen accesshttp://purl.org/coar/access_right/c_abf2Attribution 4.0 Internationalhttp://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:docta.ucm.es:20.500.14352/1178982026-06-02T12:44:21Z
dc.title.none.fl_str_mv Hospital Admission Trends in Alpha-1-Antitrypsin Deficiency: A Sex-Based Analysis from the Spanish National Discharge Database, 2016-2022
title Hospital Admission Trends in Alpha-1-Antitrypsin Deficiency: A Sex-Based Analysis from the Spanish National Discharge Database, 2016-2022
spellingShingle Hospital Admission Trends in Alpha-1-Antitrypsin Deficiency: A Sex-Based Analysis from the Spanish National Discharge Database, 2016-2022
Miguel Díez, Javier De
Alpha-1 antitrypsin deficiency
Hospital admissions
Comorbidities
In-hospital mortality
Sex-differences
Trends
Ciencias Biomédicas
32 Ciencias Médicas
title_short Hospital Admission Trends in Alpha-1-Antitrypsin Deficiency: A Sex-Based Analysis from the Spanish National Discharge Database, 2016-2022
title_full Hospital Admission Trends in Alpha-1-Antitrypsin Deficiency: A Sex-Based Analysis from the Spanish National Discharge Database, 2016-2022
title_fullStr Hospital Admission Trends in Alpha-1-Antitrypsin Deficiency: A Sex-Based Analysis from the Spanish National Discharge Database, 2016-2022
title_full_unstemmed Hospital Admission Trends in Alpha-1-Antitrypsin Deficiency: A Sex-Based Analysis from the Spanish National Discharge Database, 2016-2022
title_sort Hospital Admission Trends in Alpha-1-Antitrypsin Deficiency: A Sex-Based Analysis from the Spanish National Discharge Database, 2016-2022
dc.creator.none.fl_str_mv Miguel Díez, Javier De
López De Andrés, Ana Isabel
Zamorano León, José Javier
Hernández Barrera, Valentín
Cuadrado Corrales, María Natividad
Jiménez Sierra, Ana
Carabantes Alarcón, David
Jiménez García, Rodrigo
author Miguel Díez, Javier De
author_facet Miguel Díez, Javier De
López De Andrés, Ana Isabel
Zamorano León, José Javier
Hernández Barrera, Valentín
Cuadrado Corrales, María Natividad
Jiménez Sierra, Ana
Carabantes Alarcón, David
Jiménez García, Rodrigo
author_role author
author2 López De Andrés, Ana Isabel
Zamorano León, José Javier
Hernández Barrera, Valentín
Cuadrado Corrales, María Natividad
Jiménez Sierra, Ana
Carabantes Alarcón, David
Jiménez García, Rodrigo
author2_role author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Universidad Complutense de Madrid
dc.subject.none.fl_str_mv Alpha-1 antitrypsin deficiency
Hospital admissions
Comorbidities
In-hospital mortality
Sex-differences
Trends
Ciencias Biomédicas
32 Ciencias Médicas
topic Alpha-1 antitrypsin deficiency
Hospital admissions
Comorbidities
In-hospital mortality
Sex-differences
Trends
Ciencias Biomédicas
32 Ciencias Médicas
description bjectives: To analyze the number and clinical characteristics of hospital admissions in Spain between 2016 and 2022 in which alpha-1-antitrypsin deficiency (AATD) was coded; to describe and analyze differences in these parameters between men and women; and to identify variables associated with a worse prognosis. Methods: We used a nationwide discharge database to select all admissions featuring an AATD diagnostic code (ICD-10 code E88.01) in any position. Results: We found 5142 hospital admissions with a diagnosis of AATD and detected a significant increase in their number from 2016 to 2022 (p = 0.034 for trend). Males accounted for 58.21% of the hospitalizations and had a higher Charlson Comorbidity Index than women (1.86 vs. 1.33; p < 0.001), were hospitalized more frequently (21.18% of men were hospitalized more than once vs. 17.76% of women, p < 0.001), and had a higher probability of severe disease (OR 1.39; 95%CI 1.10-1.75). Crude in-hospital mortality (IHM) was 6.85% in men and 4.8% in women (p = 0.007). The variables associated with IHM in both sexes were older age, more hospital admissions, and liver disease or lung cancer. Invasive and non-invasive mechanical ventilation and admission to the ICU were also associated with IHM in men and women. Multivariable adjustment revealed no association between sex and IHM. Conclusions: The number of hospitalizations for AATD increased in Spain from 2016 to 2022. Men represented almost 60% of hospitalizations, were admitted more frequently and with more comorbidities, and had a higher probability of severe disease than women. There was no association between sex and IHM.
publishDate 2024
dc.date.none.fl_str_mv 2024
2024-09-22
2024
2024-09-22
dc.type.none.fl_str_mv journal article
http://purl.org/coar/resource_type/c_6501
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv https://hdl.handle.net/20.500.14352/117898
url https://hdl.handle.net/20.500.14352/117898
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
Attribution 4.0 International
http://creativecommons.org/licenses/by/4.0/
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
Attribution 4.0 International
http://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv MDPI
publisher.none.fl_str_mv MDPI
dc.source.none.fl_str_mv reponame:Docta Complutense
instname:Universidad Complutense de Madrid (UCM)
instname_str Universidad Complutense de Madrid (UCM)
reponame_str Docta Complutense
collection Docta Complutense
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,812429

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