Oxylipin profiling for clinical research: Current status and future perspectives

16 pages, 2 tables, 3 figures.-- Under a Creative Commons license

Detalles Bibliográficos
Autores: Parchem, Karol, Letsiou, Sophia, Petan, Toni, Oskolkova, Olga, Medina, Isabel, Kuda, Ondrej, O'Donnell, Valerie B., Nicolaou, Anna, Fedorova, Maria, Bochkov, Valery, Gladine, Cécile
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2024
País:España
Institución:Consejo Superior de Investigaciones Científicas (CSIC)
Repositorio:DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:oai:digital.csic.es:10261/359918
Acceso en línea:http://hdl.handle.net/10261/359918
Access Level:acceso abierto
Palabra clave:Lipid mediators
Epilipids
Lipidomics
Oxylipins
Eicosanoids
Clinical translation
id ES_e1bbf43d09fb0772c9ceeda4ebe5605c
oai_identifier_str oai:digital.csic.es:10261/359918
network_acronym_str ES
network_name_str España
repository_id_str
spelling Oxylipin profiling for clinical research: Current status and future perspectivesParchem, KarolLetsiou, SophiaPetan, ToniOskolkova, OlgaMedina, IsabelKuda, OndrejO'Donnell, Valerie B.Nicolaou, AnnaFedorova, MariaBochkov, ValeryGladine, CécileLipid mediatorsEpilipidsLipidomicsOxylipinsEicosanoidsClinical translation16 pages, 2 tables, 3 figures.-- Under a Creative Commons licenseOxylipins are potent lipid mediators with increasing interest in clinical research. They are usually measured in systemic circulation and can provide a wealth of information regarding key biological processes such as inflammation, vascular tone, or blood coagulation. Although procedures still require harmonization to generate comparable oxylipin datasets, performing comprehensive profiling of circulating oxylipins in large studies is feasible and no longer restricted by technical barriers. However, it is essential to improve and facilitate the biological interpretation of complex oxylipin profiles to truly leverage their potential in clinical research. This requires regular updating of our knowledge about the metabolism and the mode of action of oxylipins, and consideration of all factors that may influence circulating oxylipin profiles independently of the studied disease or condition. This review aims to provide the readers with updated and necessary information regarding oxylipin metabolism, their different forms in systemic circulation, the current limitations in deducing oxylipin cellular effects from in vitro bioactivity studies, the biological and technical confounding factors needed to consider for a proper interpretation of oxylipin profilesThis research did not receive any specific grant from funding agencies in the public, commercial, or not-for-profit sectorsPeer reviewedElsevierConsejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]202420242024info:eu-repo/semantics/articlehttp://purl.org/coar/resource_type/c_6501Publisher's versioninfo:eu-repo/semantics/publishedVersionhttp://hdl.handle.net/10261/359918reponame:DIGITAL.CSIC. Repositorio Institucional del CSICinstname:Consejo Superior de Investigaciones Científicas (CSIC)InglésThe underlying dataset has been published as supplementary material of the article in the publishers platform at DOI https://doi.org/10.1016/j.plipres.2024.101276https://doi.org/10.1016/j.plipres.2024.101276Síinfo:eu-repo/semantics/openAccessoai:digital.csic.es:10261/3599182026-05-22T06:33:51Z
dc.title.none.fl_str_mv Oxylipin profiling for clinical research: Current status and future perspectives
title Oxylipin profiling for clinical research: Current status and future perspectives
spellingShingle Oxylipin profiling for clinical research: Current status and future perspectives
Parchem, Karol
Lipid mediators
Epilipids
Lipidomics
Oxylipins
Eicosanoids
Clinical translation
title_short Oxylipin profiling for clinical research: Current status and future perspectives
title_full Oxylipin profiling for clinical research: Current status and future perspectives
title_fullStr Oxylipin profiling for clinical research: Current status and future perspectives
title_full_unstemmed Oxylipin profiling for clinical research: Current status and future perspectives
title_sort Oxylipin profiling for clinical research: Current status and future perspectives
dc.creator.none.fl_str_mv Parchem, Karol
Letsiou, Sophia
Petan, Toni
Oskolkova, Olga
Medina, Isabel
Kuda, Ondrej
O'Donnell, Valerie B.
Nicolaou, Anna
Fedorova, Maria
Bochkov, Valery
Gladine, Cécile
author Parchem, Karol
author_facet Parchem, Karol
Letsiou, Sophia
Petan, Toni
Oskolkova, Olga
Medina, Isabel
Kuda, Ondrej
O'Donnell, Valerie B.
Nicolaou, Anna
Fedorova, Maria
Bochkov, Valery
Gladine, Cécile
author_role author
author2 Letsiou, Sophia
Petan, Toni
Oskolkova, Olga
Medina, Isabel
Kuda, Ondrej
O'Donnell, Valerie B.
Nicolaou, Anna
Fedorova, Maria
Bochkov, Valery
Gladine, Cécile
author2_role author
author
author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]
dc.subject.none.fl_str_mv Lipid mediators
Epilipids
Lipidomics
Oxylipins
Eicosanoids
Clinical translation
topic Lipid mediators
Epilipids
Lipidomics
Oxylipins
Eicosanoids
Clinical translation
description 16 pages, 2 tables, 3 figures.-- Under a Creative Commons license
publishDate 2024
dc.date.none.fl_str_mv 2024
2024
2024
dc.type.none.fl_str_mv info:eu-repo/semantics/article
http://purl.org/coar/resource_type/c_6501
Publisher's version
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10261/359918
url http://hdl.handle.net/10261/359918
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv The underlying dataset has been published as supplementary material of the article in the publishers platform at DOI https://doi.org/10.1016/j.plipres.2024.101276
https://doi.org/10.1016/j.plipres.2024.101276
Sí
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:DIGITAL.CSIC. Repositorio Institucional del CSIC
instname:Consejo Superior de Investigaciones Científicas (CSIC)
instname_str Consejo Superior de Investigaciones Científicas (CSIC)
reponame_str DIGITAL.CSIC. Repositorio Institucional del CSIC
collection DIGITAL.CSIC. Repositorio Institucional del CSIC
repository.name.fl_str_mv
repository.mail.fl_str_mv
_version_ 1869422320383164417
score 15,811543

Similares en LA Referencia