Increased cardiovascular risk markers in obesity are associated with body adiposity: role of leptin

Gomez-Ambrosi, J. (Javier)|||/items/21d09997-940a-45f7-9b4b-0a9f64b2ed8e; Salvador-Rodríguez, F.J. (Francisco Javier)|||/items/1175815b-412b-41a6-b91f-6dbfa349f9c8; Silva-Frojan, C. (Camilo)|||/items/4037daf2-cf27-42c3-b76c-2ad9aa9465ef; Pastor-Idoate, C. (Carlos)|||/items/db004f1c-c96b-428d-b929-408dda2c568d; Rotellar-Sastre, F. (Fernando)|||/items/833cb788-f4b9-404d-a18b-ae1c84369b51; Gil, M.J. (María José)|||/items/ab59091b-9346-4377-8462-bfa48090ba46; Álvarez-Cienfuegos, J. (Javier)|||/items/88871d37-0dae-4312-a6d8-0596bc69158c; Frühbeck, G. (Gema)|||/items/7f0b1f72-bc91-4ab0-a3fd-21e9a3fb663b

Increased cardiovascular risk markers in obesity are associated with body adiposity: role of leptin

Epidemiological studies have shown that obesity is associated with increased blood concentrations of proinflammatory factors and markers of endothelial dysfunction such as fibrinogen, C-reactive protein (CRP), and von Willebrand factor (vWF). We analyzed the association of these markers with percent...

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Authors:	Gomez-Ambrosi, J. (Javier)\|\|\|/items/21d09997-940a-45f7-9b4b-0a9f64b2ed8e, Salvador-Rodríguez, F.J. (Francisco Javier)\|\|\|/items/1175815b-412b-41a6-b91f-6dbfa349f9c8, Silva-Frojan, C. (Camilo)\|\|\|/items/4037daf2-cf27-42c3-b76c-2ad9aa9465ef, Pastor-Idoate, C. (Carlos)\|\|\|/items/db004f1c-c96b-428d-b929-408dda2c568d, Rotellar-Sastre, F. (Fernando)\|\|\|/items/833cb788-f4b9-404d-a18b-ae1c84369b51, Gil, M.J. (María José)\|\|\|/items/ab59091b-9346-4377-8462-bfa48090ba46, Álvarez-Cienfuegos, J. (Javier)\|\|\|/items/88871d37-0dae-4312-a6d8-0596bc69158c, Frühbeck, G. (Gema)\|\|\|/items/7f0b1f72-bc91-4ab0-a3fd-21e9a3fb663b
Format:	article
Publication Date:	2006
Country:	España
Institution:	Universidad de Navarra
Repository:	Dadun. Depósito Académico Digital de la Universidad de Navarra
Language:	English
OAI Identifier:	oai:dadun.unav.edu:10171/21877
Online Access:	https://hdl.handle.net/10171/21877
Access Level:	Open access
Keyword:	Obesity C-Reactive Protein/metabolism Cardiovascular Diseases/blood/etiology/metabolism Leptin/blood

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network_name_str	España
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spelling	Increased cardiovascular risk markers in obesity are associated with body adiposity: role of leptinGomez-Ambrosi, J. (Javier)\|\|\|/items/21d09997-940a-45f7-9b4b-0a9f64b2ed8eSalvador-Rodríguez, F.J. (Francisco Javier)\|\|\|/items/1175815b-412b-41a6-b91f-6dbfa349f9c8Silva-Frojan, C. (Camilo)\|\|\|/items/4037daf2-cf27-42c3-b76c-2ad9aa9465efPastor-Idoate, C. (Carlos)\|\|\|/items/db004f1c-c96b-428d-b929-408dda2c568dRotellar-Sastre, F. (Fernando)\|\|\|/items/833cb788-f4b9-404d-a18b-ae1c84369b51Gil, M.J. (María José)\|\|\|/items/ab59091b-9346-4377-8462-bfa48090ba46Álvarez-Cienfuegos, J. (Javier)\|\|\|/items/88871d37-0dae-4312-a6d8-0596bc69158cFrühbeck, G. (Gema)\|\|\|/items/7f0b1f72-bc91-4ab0-a3fd-21e9a3fb663bObesityC-Reactive Protein/metabolismCardiovascular Diseases/blood/etiology/metabolismLeptin/bloodEpidemiological studies have shown that obesity is associated with increased blood concentrations of proinflammatory factors and markers of endothelial dysfunction such as fibrinogen, C-reactive protein (CRP), and von Willebrand factor (vWF). We analyzed the association of these markers with percentage of body fat (BF), and the influence of leptin in a cross-sectional study of 1,089 subjects (366 men) aged 44 (34-53) [median (interquartile range)] years, who were classified as obese or nonobese according to BF estimated by whole-body air displacement plethysmography. Obesity was defined as BF >or= 25% in men and >or= 35% in women. Compared with non-obese subjects (mean +/- SD), obese patients had higher concentrations of fibrinogen (312 +/- 78 vs. 342 +/- 81 mg/dl, P < 0.001), CRP (0.41 +/- 0.75 vs. 0.75 +/- 1.04 mg/l, P = 0.014), vWF (107 +/- 29 vs. 123 +/- 55%, P < 0.001), and leptin (10.4 +/- 6.5 vs. 37.5 +/- 26.1 ng/ml, P < 0.0001). A positive correlation was observed between BF and fibrinogen (r = 0.266; P < 0.0001), logCRP (r = 0.409; P < 0.0001), and vWF (r = 206; P < 0.0001). Leptin was correlated with fibrinogen (r = 0.219, P < 0.0001), logCRP (r = 0., P < 0.0001), and vWF (r = 0.124, P = 0.002), but the statistical significance was lost after including BF in adjusted-correlation and multivariate analysis, suggesting that they are not regulated by leptin per se. In conclusion, the obesity-associated increase in the circulating concentrations of fibrinogen, CRP, and vWF is highly associated to BF and apparently not determined by leptinSchattauerDadun. Depósito Académico Digital Universidad de Navarra20122012-05-0220062006-01-0120062006-01-01journal articlehttp://purl.org/coar/resource_type/c_6501info:eu-repo/semantics/articleapplication/pdfhttps://hdl.handle.net/10171/21877reponame:Dadun. Depósito Académico Digital de la Universidad de Navarrainstname:Universidad de NavarraInglésengopen accesshttp://purl.org/coar/access_right/c_abf2info:eu-repo/semantics/openAccessoai:dadun.unav.edu:10171/218772026-06-21T12:47:57Z
dc.title.none.fl_str_mv	Increased cardiovascular risk markers in obesity are associated with body adiposity: role of leptin
title	Increased cardiovascular risk markers in obesity are associated with body adiposity: role of leptin
spellingShingle	Increased cardiovascular risk markers in obesity are associated with body adiposity: role of leptin Gomez-Ambrosi, J. (Javier)\|\|\|/items/21d09997-940a-45f7-9b4b-0a9f64b2ed8e Obesity C-Reactive Protein/metabolism Cardiovascular Diseases/blood/etiology/metabolism Leptin/blood
title_short	Increased cardiovascular risk markers in obesity are associated with body adiposity: role of leptin
title_full	Increased cardiovascular risk markers in obesity are associated with body adiposity: role of leptin
title_fullStr	Increased cardiovascular risk markers in obesity are associated with body adiposity: role of leptin
title_full_unstemmed	Increased cardiovascular risk markers in obesity are associated with body adiposity: role of leptin
title_sort	Increased cardiovascular risk markers in obesity are associated with body adiposity: role of leptin
dc.creator.none.fl_str_mv	Gomez-Ambrosi, J. (Javier)\|\|\|/items/21d09997-940a-45f7-9b4b-0a9f64b2ed8e Salvador-Rodríguez, F.J. (Francisco Javier)\|\|\|/items/1175815b-412b-41a6-b91f-6dbfa349f9c8 Silva-Frojan, C. (Camilo)\|\|\|/items/4037daf2-cf27-42c3-b76c-2ad9aa9465ef Pastor-Idoate, C. (Carlos)\|\|\|/items/db004f1c-c96b-428d-b929-408dda2c568d Rotellar-Sastre, F. (Fernando)\|\|\|/items/833cb788-f4b9-404d-a18b-ae1c84369b51 Gil, M.J. (María José)\|\|\|/items/ab59091b-9346-4377-8462-bfa48090ba46 Álvarez-Cienfuegos, J. (Javier)\|\|\|/items/88871d37-0dae-4312-a6d8-0596bc69158c Frühbeck, G. (Gema)\|\|\|/items/7f0b1f72-bc91-4ab0-a3fd-21e9a3fb663b
author	Gomez-Ambrosi, J. (Javier)\|\|\|/items/21d09997-940a-45f7-9b4b-0a9f64b2ed8e
author_facet	Gomez-Ambrosi, J. (Javier)\|\|\|/items/21d09997-940a-45f7-9b4b-0a9f64b2ed8e Salvador-Rodríguez, F.J. (Francisco Javier)\|\|\|/items/1175815b-412b-41a6-b91f-6dbfa349f9c8 Silva-Frojan, C. (Camilo)\|\|\|/items/4037daf2-cf27-42c3-b76c-2ad9aa9465ef Pastor-Idoate, C. (Carlos)\|\|\|/items/db004f1c-c96b-428d-b929-408dda2c568d Rotellar-Sastre, F. (Fernando)\|\|\|/items/833cb788-f4b9-404d-a18b-ae1c84369b51 Gil, M.J. (María José)\|\|\|/items/ab59091b-9346-4377-8462-bfa48090ba46 Álvarez-Cienfuegos, J. (Javier)\|\|\|/items/88871d37-0dae-4312-a6d8-0596bc69158c Frühbeck, G. (Gema)\|\|\|/items/7f0b1f72-bc91-4ab0-a3fd-21e9a3fb663b
author_role	author
author2	Salvador-Rodríguez, F.J. (Francisco Javier)\|\|\|/items/1175815b-412b-41a6-b91f-6dbfa349f9c8 Silva-Frojan, C. (Camilo)\|\|\|/items/4037daf2-cf27-42c3-b76c-2ad9aa9465ef Pastor-Idoate, C. (Carlos)\|\|\|/items/db004f1c-c96b-428d-b929-408dda2c568d Rotellar-Sastre, F. (Fernando)\|\|\|/items/833cb788-f4b9-404d-a18b-ae1c84369b51 Gil, M.J. (María José)\|\|\|/items/ab59091b-9346-4377-8462-bfa48090ba46 Álvarez-Cienfuegos, J. (Javier)\|\|\|/items/88871d37-0dae-4312-a6d8-0596bc69158c Frühbeck, G. (Gema)\|\|\|/items/7f0b1f72-bc91-4ab0-a3fd-21e9a3fb663b
author2_role	author author author author author author author
dc.contributor.none.fl_str_mv	Dadun. Depósito Académico Digital Universidad de Navarra
dc.subject.none.fl_str_mv	Obesity C-Reactive Protein/metabolism Cardiovascular Diseases/blood/etiology/metabolism Leptin/blood
topic	Obesity C-Reactive Protein/metabolism Cardiovascular Diseases/blood/etiology/metabolism Leptin/blood
description	Epidemiological studies have shown that obesity is associated with increased blood concentrations of proinflammatory factors and markers of endothelial dysfunction such as fibrinogen, C-reactive protein (CRP), and von Willebrand factor (vWF). We analyzed the association of these markers with percentage of body fat (BF), and the influence of leptin in a cross-sectional study of 1,089 subjects (366 men) aged 44 (34-53) [median (interquartile range)] years, who were classified as obese or nonobese according to BF estimated by whole-body air displacement plethysmography. Obesity was defined as BF >or= 25% in men and >or= 35% in women. Compared with non-obese subjects (mean +/- SD), obese patients had higher concentrations of fibrinogen (312 +/- 78 vs. 342 +/- 81 mg/dl, P < 0.001), CRP (0.41 +/- 0.75 vs. 0.75 +/- 1.04 mg/l, P = 0.014), vWF (107 +/- 29 vs. 123 +/- 55%, P < 0.001), and leptin (10.4 +/- 6.5 vs. 37.5 +/- 26.1 ng/ml, P < 0.0001). A positive correlation was observed between BF and fibrinogen (r = 0.266; P < 0.0001), logCRP (r = 0.409; P < 0.0001), and vWF (r = 206; P < 0.0001). Leptin was correlated with fibrinogen (r = 0.219, P < 0.0001), logCRP (r = 0., P < 0.0001), and vWF (r = 0.124, P = 0.002), but the statistical significance was lost after including BF in adjusted-correlation and multivariate analysis, suggesting that they are not regulated by leptin per se. In conclusion, the obesity-associated increase in the circulating concentrations of fibrinogen, CRP, and vWF is highly associated to BF and apparently not determined by leptin
publishDate	2006
dc.date.none.fl_str_mv	2006 2006-01-01 2006 2006-01-01 2012 2012-05-02
dc.type.none.fl_str_mv	journal article http://purl.org/coar/resource_type/c_6501
dc.type.openaire.fl_str_mv	info:eu-repo/semantics/article
format	article
dc.identifier.none.fl_str_mv	https://hdl.handle.net/10171/21877
url	https://hdl.handle.net/10171/21877
dc.language.none.fl_str_mv	Inglés eng
language_invalid_str_mv	Inglés
language	eng
dc.rights.none.fl_str_mv	open access http://purl.org/coar/access_right/c_abf2
dc.rights.openaire.fl_str_mv	info:eu-repo/semantics/openAccess
rights_invalid_str_mv	open access http://purl.org/coar/access_right/c_abf2
eu_rights_str_mv	openAccess
dc.format.none.fl_str_mv	application/pdf
dc.publisher.none.fl_str_mv	Schattauer
publisher.none.fl_str_mv	Schattauer
dc.source.none.fl_str_mv	reponame:Dadun. Depósito Académico Digital de la Universidad de Navarra instname:Universidad de Navarra
instname_str	Universidad de Navarra
reponame_str	Dadun. Depósito Académico Digital de la Universidad de Navarra
collection	Dadun. Depósito Académico Digital de la Universidad de Navarra
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score	15,301629

Increased cardiovascular risk markers in obesity are associated with body adiposity: role of leptin

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