Vocal Music Listening Enhances Poststroke Language Network Reorganization

Listening to vocal music has been recently shown to improve language recovery in stroke survivors. The neuroplasticity mechanisms supporting this effect are, however, still unknown. Using data from a three-arm single-blind randomized controlled trial including acute stroke patients (N=38) and a 3-mo...

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Autores: Sihvonen, Aleksi J., Ripollés, Pablo, Leo, Vera, Saunavaara, Jani, Parkkola, Riitta, Rodríguez Fornells, Antoni, Soinila, Seppo, Särkämö, Teppo
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2021
País:España
Institución:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Repositorio:Recercat. Dipósit de la Recerca de Catalunya
OAI Identifier:oai:recercat.cat:2445/182756
Acceso en línea:https://hdl.handle.net/2445/182756
Access Level:acceso abierto
Palabra clave:Musicoteràpia
Malalties cerebrovasculars
Music therapy
Cerebrovascular disease
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spelling Vocal Music Listening Enhances Poststroke Language Network ReorganizationSihvonen, Aleksi J.Ripollés, PabloLeo, VeraSaunavaara, JaniParkkola, RiittaRodríguez Fornells, AntoniSoinila, SeppoSärkämö, TeppoMusicoteràpiaMalalties cerebrovascularsMusic therapyCerebrovascular diseaseListening to vocal music has been recently shown to improve language recovery in stroke survivors. The neuroplasticity mechanisms supporting this effect are, however, still unknown. Using data from a three-arm single-blind randomized controlled trial including acute stroke patients (N=38) and a 3-month follow-up, we set out to compare the neuroplasticity effects of daily listening to self-selected vocal music, instrumental music, and audiobooks on both brain activity and structural connectivity of the language network. Using deterministic tractography we show that the 3-month intervention induced an enhancement of the microstructural properties of the left frontal aslant tract (FAT) for the vocal music group as compared to the audiobook group. Importantly, this increase in the strength of the structural connectivity of the left FAT correlated with improved language skills. Analyses of stimulus-specific activation changes showed that the vocal music group exhibited increased activations in the frontal termination points of the left FAT during vocal music listening as compared to the audiobook group from acute to 3-month post-stroke stage. The increased activity correlated with the structural neuroplasticity changes in the left FAT. These results suggest that the beneficial effects of vocal music listening on post-stroke language recovery are underpinned by structural neuroplasticity changes within the language network and extend our understanding of music-based interventions in stroke rehabilitation.Significance statementPost-stroke language deficits have a devastating effect on patients and their families. Current treatments yield highly variable outcomes and the evidence for their long-term effects is limited. Patients often receive insufficient treatment that are predominantly given outside the optimal time window for brain plasticity. Post-stroke vocal music listening improves language outcome which is underpinned by neuroplasticity changes within the language network. Vocal music listening provides a complementary rehabilitation strategy which could be safely implemented in the early stages of stroke rehabilitation and seems to specifically target language symptoms and recovering language network.Society for Neuroscience2022202220212022info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersion2373-2822application/pdfhttps://hdl.handle.net/2445/182756Articles publicats en revistes (Cognició, Desenvolupament i Psicologia de l'Educació)reponame:Recercat. Dipósit de la Recerca de Catalunyainstname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)InglésReproducció del document publicat a: https://doi.org/10.1523/ENEURO.0158-21.2021eneuro, 2021, vol. 8, num. 4, p. 158https://doi.org/10.1523/ENEURO.0158-21.2021info:eu-repo/grantAgreement/EC/H2020/803466cc-by Sihvonen, Aleksi J.et al, 2021http://creativecommons.org/licenses/by/3.0/es/info:eu-repo/semantics/openAccessoai:recercat.cat:2445/1827562026-05-29T05:05:01Z
dc.title.none.fl_str_mv Vocal Music Listening Enhances Poststroke Language Network Reorganization
title Vocal Music Listening Enhances Poststroke Language Network Reorganization
spellingShingle Vocal Music Listening Enhances Poststroke Language Network Reorganization
Sihvonen, Aleksi J.
Musicoteràpia
Malalties cerebrovasculars
Music therapy
Cerebrovascular disease
title_short Vocal Music Listening Enhances Poststroke Language Network Reorganization
title_full Vocal Music Listening Enhances Poststroke Language Network Reorganization
title_fullStr Vocal Music Listening Enhances Poststroke Language Network Reorganization
title_full_unstemmed Vocal Music Listening Enhances Poststroke Language Network Reorganization
title_sort Vocal Music Listening Enhances Poststroke Language Network Reorganization
dc.creator.none.fl_str_mv Sihvonen, Aleksi J.
Ripollés, Pablo
Leo, Vera
Saunavaara, Jani
Parkkola, Riitta
Rodríguez Fornells, Antoni
Soinila, Seppo
Särkämö, Teppo
author Sihvonen, Aleksi J.
author_facet Sihvonen, Aleksi J.
Ripollés, Pablo
Leo, Vera
Saunavaara, Jani
Parkkola, Riitta
Rodríguez Fornells, Antoni
Soinila, Seppo
Särkämö, Teppo
author_role author
author2 Ripollés, Pablo
Leo, Vera
Saunavaara, Jani
Parkkola, Riitta
Rodríguez Fornells, Antoni
Soinila, Seppo
Särkämö, Teppo
author2_role author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Musicoteràpia
Malalties cerebrovasculars
Music therapy
Cerebrovascular disease
topic Musicoteràpia
Malalties cerebrovasculars
Music therapy
Cerebrovascular disease
description Listening to vocal music has been recently shown to improve language recovery in stroke survivors. The neuroplasticity mechanisms supporting this effect are, however, still unknown. Using data from a three-arm single-blind randomized controlled trial including acute stroke patients (N=38) and a 3-month follow-up, we set out to compare the neuroplasticity effects of daily listening to self-selected vocal music, instrumental music, and audiobooks on both brain activity and structural connectivity of the language network. Using deterministic tractography we show that the 3-month intervention induced an enhancement of the microstructural properties of the left frontal aslant tract (FAT) for the vocal music group as compared to the audiobook group. Importantly, this increase in the strength of the structural connectivity of the left FAT correlated with improved language skills. Analyses of stimulus-specific activation changes showed that the vocal music group exhibited increased activations in the frontal termination points of the left FAT during vocal music listening as compared to the audiobook group from acute to 3-month post-stroke stage. The increased activity correlated with the structural neuroplasticity changes in the left FAT. These results suggest that the beneficial effects of vocal music listening on post-stroke language recovery are underpinned by structural neuroplasticity changes within the language network and extend our understanding of music-based interventions in stroke rehabilitation.Significance statementPost-stroke language deficits have a devastating effect on patients and their families. Current treatments yield highly variable outcomes and the evidence for their long-term effects is limited. Patients often receive insufficient treatment that are predominantly given outside the optimal time window for brain plasticity. Post-stroke vocal music listening improves language outcome which is underpinned by neuroplasticity changes within the language network. Vocal music listening provides a complementary rehabilitation strategy which could be safely implemented in the early stages of stroke rehabilitation and seems to specifically target language symptoms and recovering language network.
publishDate 2021
dc.date.none.fl_str_mv 2021
2022
2022
2022
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/2445/182756
url https://hdl.handle.net/2445/182756
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Reproducció del document publicat a: https://doi.org/10.1523/ENEURO.0158-21.2021
eneuro, 2021, vol. 8, num. 4, p. 158
https://doi.org/10.1523/ENEURO.0158-21.2021
info:eu-repo/grantAgreement/EC/H2020/803466
dc.rights.none.fl_str_mv cc-by Sihvonen, Aleksi J.et al, 2021
http://creativecommons.org/licenses/by/3.0/es/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv cc-by Sihvonen, Aleksi J.et al, 2021
http://creativecommons.org/licenses/by/3.0/es/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 2373-2822
application/pdf
dc.publisher.none.fl_str_mv Society for Neuroscience
publisher.none.fl_str_mv Society for Neuroscience
dc.source.none.fl_str_mv Articles publicats en revistes (Cognició, Desenvolupament i Psicologia de l'Educació)
reponame:Recercat. Dipósit de la Recerca de Catalunya
instname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
instname_str Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
reponame_str Recercat. Dipósit de la Recerca de Catalunya
collection Recercat. Dipósit de la Recerca de Catalunya
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15.812455

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