The EBMT activity survey on hematopoietic-cell transplantation and cellular therapy 2018: CAR-T’s come into focus

Hematopoietic-cell transplantation (HCT) is widely used for acquired and congenital disorders of the hematopoietic system. Number of transplants performed in Europe and associated countries continues to rise with 47,468 HCT in 42,901 patients [19,630 allogeneic (41%) and 27,838 autologous (59%)] rep...

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Autores: Passweg, Jakob R., Baldomero, Helen, Chabannon, Christian, Basak, Grzegorz W., Corbacioglu, Selim, Duarte Palomino, Rafael, Dolstra, Harry, Lankester, Arjan C., Mohty, Mohamad, Montoto, Silvia, Peffault de Latour, Régis, Snowden, John A., Styczynski, Jan, Yakoub-Agha, Ibrahim, Kröger, Nicolaus
Formato: artículo
Fecha de publicación:2020
País:España
Recursos:Universidad Autónoma de Madrid
Repositorio:Biblos-e Archivo. Repositorio Institucional de la UAM
Idioma:inglés
OAI Identifier:oai:repositorio.uam.es:10486/694781
Acesso em linha:http://hdl.handle.net/10486/694781
https://dx.doi.org/10.1038/s41409-020-0826-4
Access Level:acceso abierto
Palavra-chave:Hematopoietic-cell transplantation (HCT)
Lymphoid malignancies
Cellular therapies
European Society for Blood and Marrow Transplantation (EBMT)
Medicina
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spelling The EBMT activity survey on hematopoietic-cell transplantation and cellular therapy 2018: CAR-T’s come into focusPassweg, Jakob R.Baldomero, HelenChabannon, ChristianBasak, Grzegorz W.Corbacioglu, SelimDuarte Palomino, RafaelDolstra, HarryLankester, Arjan C.Mohty, MohamadMontoto, SilviaPeffault de Latour, RégisSnowden, John A.Styczynski, JanYakoub-Agha, IbrahimKröger, NicolausHematopoietic-cell transplantation (HCT)Lymphoid malignanciesCellular therapiesEuropean Society for Blood and Marrow Transplantation (EBMT)MedicinaHematopoietic-cell transplantation (HCT) is widely used for acquired and congenital disorders of the hematopoietic system. Number of transplants performed in Europe and associated countries continues to rise with 47,468 HCT in 42,901 patients [19,630 allogeneic (41%) and 27,838 autologous (59%)] reported by 701 centers in 50 countries in 2018. Main indications were myeloid malignancies 10,679 (25%; 97% allogeneic), lymphoid malignancies 27,318 (64%; 20% allogeneic), solid tumors 1625 (4%; 2.9% allogeneic), and nonmalignant disorders 3063 (7%; 81% allogeneic). This year’s analysis focuses on cellular therapies with the marked growth in CAR T-cell therapies from 151 in 2017 to 301 patients reported in 2018. Other cellular therapy numbers show less significant changes. Important trends in HCT include a 49% increase in allogeneic HCT for chronic phase CML (although transplant numbers remain low) and a 24% increase in aplastic anemia. In autologous HCT, there is an ongoing increase in autoimmune diseases (by 19%), predominantly due to activity in multiple sclerosis. This annual report reflects current activity and highlights important trends, useful for health care planning.Springer NatureDepartamento de MedicinaFacultad de Medicina20202020-02-17research articlehttp://purl.org/coar/resource_type/c_2df8fbb1VoRhttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10486/694781https://dx.doi.org/10.1038/s41409-020-0826-4reponame:Biblos-e Archivo. Repositorio Institucional de la UAMinstname:Universidad Autónoma de MadridInglésengopen accesshttp://purl.org/coar/access_right/c_abf2info:eu-repo/semantics/openAccessoai:repositorio.uam.es:10486/6947812026-06-23T12:46:27Z
dc.title.none.fl_str_mv The EBMT activity survey on hematopoietic-cell transplantation and cellular therapy 2018: CAR-T’s come into focus
title The EBMT activity survey on hematopoietic-cell transplantation and cellular therapy 2018: CAR-T’s come into focus
spellingShingle The EBMT activity survey on hematopoietic-cell transplantation and cellular therapy 2018: CAR-T’s come into focus
Passweg, Jakob R.
Hematopoietic-cell transplantation (HCT)
Lymphoid malignancies
Cellular therapies
European Society for Blood and Marrow Transplantation (EBMT)
Medicina
title_short The EBMT activity survey on hematopoietic-cell transplantation and cellular therapy 2018: CAR-T’s come into focus
title_full The EBMT activity survey on hematopoietic-cell transplantation and cellular therapy 2018: CAR-T’s come into focus
title_fullStr The EBMT activity survey on hematopoietic-cell transplantation and cellular therapy 2018: CAR-T’s come into focus
title_full_unstemmed The EBMT activity survey on hematopoietic-cell transplantation and cellular therapy 2018: CAR-T’s come into focus
title_sort The EBMT activity survey on hematopoietic-cell transplantation and cellular therapy 2018: CAR-T’s come into focus
dc.creator.none.fl_str_mv Passweg, Jakob R.
Baldomero, Helen
Chabannon, Christian
Basak, Grzegorz W.
Corbacioglu, Selim
Duarte Palomino, Rafael
Dolstra, Harry
Lankester, Arjan C.
Mohty, Mohamad
Montoto, Silvia
Peffault de Latour, Régis
Snowden, John A.
Styczynski, Jan
Yakoub-Agha, Ibrahim
Kröger, Nicolaus
author Passweg, Jakob R.
author_facet Passweg, Jakob R.
Baldomero, Helen
Chabannon, Christian
Basak, Grzegorz W.
Corbacioglu, Selim
Duarte Palomino, Rafael
Dolstra, Harry
Lankester, Arjan C.
Mohty, Mohamad
Montoto, Silvia
Peffault de Latour, Régis
Snowden, John A.
Styczynski, Jan
Yakoub-Agha, Ibrahim
Kröger, Nicolaus
author_role author
author2 Baldomero, Helen
Chabannon, Christian
Basak, Grzegorz W.
Corbacioglu, Selim
Duarte Palomino, Rafael
Dolstra, Harry
Lankester, Arjan C.
Mohty, Mohamad
Montoto, Silvia
Peffault de Latour, Régis
Snowden, John A.
Styczynski, Jan
Yakoub-Agha, Ibrahim
Kröger, Nicolaus
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Departamento de Medicina
Facultad de Medicina
dc.subject.none.fl_str_mv Hematopoietic-cell transplantation (HCT)
Lymphoid malignancies
Cellular therapies
European Society for Blood and Marrow Transplantation (EBMT)
Medicina
topic Hematopoietic-cell transplantation (HCT)
Lymphoid malignancies
Cellular therapies
European Society for Blood and Marrow Transplantation (EBMT)
Medicina
description Hematopoietic-cell transplantation (HCT) is widely used for acquired and congenital disorders of the hematopoietic system. Number of transplants performed in Europe and associated countries continues to rise with 47,468 HCT in 42,901 patients [19,630 allogeneic (41%) and 27,838 autologous (59%)] reported by 701 centers in 50 countries in 2018. Main indications were myeloid malignancies 10,679 (25%; 97% allogeneic), lymphoid malignancies 27,318 (64%; 20% allogeneic), solid tumors 1625 (4%; 2.9% allogeneic), and nonmalignant disorders 3063 (7%; 81% allogeneic). This year’s analysis focuses on cellular therapies with the marked growth in CAR T-cell therapies from 151 in 2017 to 301 patients reported in 2018. Other cellular therapy numbers show less significant changes. Important trends in HCT include a 49% increase in allogeneic HCT for chronic phase CML (although transplant numbers remain low) and a 24% increase in aplastic anemia. In autologous HCT, there is an ongoing increase in autoimmune diseases (by 19%), predominantly due to activity in multiple sclerosis. This annual report reflects current activity and highlights important trends, useful for health care planning.
publishDate 2020
dc.date.none.fl_str_mv 2020
2020-02-17
dc.type.none.fl_str_mv research article
http://purl.org/coar/resource_type/c_2df8fbb1
VoR
http://purl.org/coar/version/c_970fb48d4fbd8a85
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv http://hdl.handle.net/10486/694781
https://dx.doi.org/10.1038/s41409-020-0826-4
url http://hdl.handle.net/10486/694781
https://dx.doi.org/10.1038/s41409-020-0826-4
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Springer Nature
publisher.none.fl_str_mv Springer Nature
dc.source.none.fl_str_mv reponame:Biblos-e Archivo. Repositorio Institucional de la UAM
instname:Universidad Autónoma de Madrid
instname_str Universidad Autónoma de Madrid
reponame_str Biblos-e Archivo. Repositorio Institucional de la UAM
collection Biblos-e Archivo. Repositorio Institucional de la UAM
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,300719

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