Hitchhiking with nature: snake venom peptides to fight cancer and superbugs

For decades, natural products in general and snake venoms (SV) in particular have been a rich source of bioactive compounds for drug discovery, and they remain a promising substrate for therapeutic development. Currently, a handful of SV-based drugs for diagnosis and treatment of various cardiovascu...

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Detalles Bibliográficos
Autores: Pérez-Peinado, Clara, 1991-, Defaus, Sira, Andreu Martínez, David
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2020
País:España
Institución:Universitat Pompeu Fabra
Repositorio:Repositorio Digital de la UPF
OAI Identifier:oai:repositori.upf.edu:10230/44439
Acceso en línea:http://hdl.handle.net/10230/44439
http://dx.doi.org/10.3390/toxins12040255
Access Level:acceso abierto
Palabra clave:Anticancer peptides
Antimicrobial peptides
Cathelicidin
Crotamine
Defensin
Snake venom peptides
Snake venom proteins
Snake venoms
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spelling Hitchhiking with nature: snake venom peptides to fight cancer and superbugsPérez-Peinado, Clara, 1991-Defaus, SiraAndreu Martínez, DavidAnticancer peptidesAntimicrobial peptidesCathelicidinCrotamineDefensinSnake venom peptidesSnake venom proteinsSnake venomsFor decades, natural products in general and snake venoms (SV) in particular have been a rich source of bioactive compounds for drug discovery, and they remain a promising substrate for therapeutic development. Currently, a handful of SV-based drugs for diagnosis and treatment of various cardiovascular disorders and blood abnormalities are on the market. Likewise, far more SV compounds and their mimetics are under investigation today for diverse therapeutic applications, including antibiotic-resistant bacteria and cancer. In this review, we analyze the state of the art regarding SV-derived compounds with therapeutic potential, focusing on the development of antimicrobial and anticancer drugs. Specifically, information about SV peptides experimentally validated or predicted to act as antimicrobial and anticancer peptides (AMPs and ACPs, respectively) has been collected and analyzed. Their principal activities both in vitro and in vivo, structures, mechanisms of action, and attempts at sequence optimization are discussed in order to highlight their potential as drug leads.MDPI202020202020info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfapplication/pdfhttp://hdl.handle.net/10230/44439http://dx.doi.org/10.3390/toxins12040255reponame:Repositorio Digital de la UPFinstname:Universitat Pompeu FabraInglésToxins (Basel). 2020; 12(4). pii: E255© 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).http://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:repositori.upf.edu:10230/444392026-06-12T07:21:37Z
dc.title.none.fl_str_mv Hitchhiking with nature: snake venom peptides to fight cancer and superbugs
title Hitchhiking with nature: snake venom peptides to fight cancer and superbugs
spellingShingle Hitchhiking with nature: snake venom peptides to fight cancer and superbugs
Pérez-Peinado, Clara, 1991-
Anticancer peptides
Antimicrobial peptides
Cathelicidin
Crotamine
Defensin
Snake venom peptides
Snake venom proteins
Snake venoms
title_short Hitchhiking with nature: snake venom peptides to fight cancer and superbugs
title_full Hitchhiking with nature: snake venom peptides to fight cancer and superbugs
title_fullStr Hitchhiking with nature: snake venom peptides to fight cancer and superbugs
title_full_unstemmed Hitchhiking with nature: snake venom peptides to fight cancer and superbugs
title_sort Hitchhiking with nature: snake venom peptides to fight cancer and superbugs
dc.creator.none.fl_str_mv Pérez-Peinado, Clara, 1991-
Defaus, Sira
Andreu Martínez, David
author Pérez-Peinado, Clara, 1991-
author_facet Pérez-Peinado, Clara, 1991-
Defaus, Sira
Andreu Martínez, David
author_role author
author2 Defaus, Sira
Andreu Martínez, David
author2_role author
author
dc.subject.none.fl_str_mv Anticancer peptides
Antimicrobial peptides
Cathelicidin
Crotamine
Defensin
Snake venom peptides
Snake venom proteins
Snake venoms
topic Anticancer peptides
Antimicrobial peptides
Cathelicidin
Crotamine
Defensin
Snake venom peptides
Snake venom proteins
Snake venoms
description For decades, natural products in general and snake venoms (SV) in particular have been a rich source of bioactive compounds for drug discovery, and they remain a promising substrate for therapeutic development. Currently, a handful of SV-based drugs for diagnosis and treatment of various cardiovascular disorders and blood abnormalities are on the market. Likewise, far more SV compounds and their mimetics are under investigation today for diverse therapeutic applications, including antibiotic-resistant bacteria and cancer. In this review, we analyze the state of the art regarding SV-derived compounds with therapeutic potential, focusing on the development of antimicrobial and anticancer drugs. Specifically, information about SV peptides experimentally validated or predicted to act as antimicrobial and anticancer peptides (AMPs and ACPs, respectively) has been collected and analyzed. Their principal activities both in vitro and in vivo, structures, mechanisms of action, and attempts at sequence optimization are discussed in order to highlight their potential as drug leads.
publishDate 2020
dc.date.none.fl_str_mv 2020
2020
2020
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10230/44439
http://dx.doi.org/10.3390/toxins12040255
url http://hdl.handle.net/10230/44439
http://dx.doi.org/10.3390/toxins12040255
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Toxins (Basel). 2020; 12(4). pii: E255
dc.rights.none.fl_str_mv http://creativecommons.org/licenses/by/4.0/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv http://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv MDPI
publisher.none.fl_str_mv MDPI
dc.source.none.fl_str_mv reponame:Repositorio Digital de la UPF
instname:Universitat Pompeu Fabra
instname_str Universitat Pompeu Fabra
reponame_str Repositorio Digital de la UPF
collection Repositorio Digital de la UPF
repository.name.fl_str_mv
repository.mail.fl_str_mv
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