Asthma with bronchial hypersecretion

1) Define the clinical and inflammatory phenotype of asthma with bronchial hypersecretion of mucus. 2) Compare the type of mucin present in induced sputum (IS) of patients with and without bronchial hypersecretion. 3) Determine the expression of TLRs in IS and blood of asthmatics with and without br...

Descripción completa

Detalles Bibliográficos
Autores: Crespo Lessmann, Astrid|||0000-0002-2238-6851, Mateus, Eder, Torrejón, Montserrat|||0000-0002-0819-6066, Belda Soler, Alicia, Giner, Jordi|||0000-0002-3044-2059, Vidal, Silvia|||0000-0002-3909-6682, Sibila, Oriol|||0000-0002-4833-6713, Plaza, Vicente|||0000-0003-2567-5496
Tipo de recurso: artículo
Fecha de publicación:2017
País:España
Institución:Universitat Autònoma de Barcelona
Repositorio:Dipòsit Digital de Documents de la UAB
Idioma:inglés
OAI Identifier:oai:ddd.uab.cat:186365
Acceso en línea:https://ddd.uab.cat/record/186365
https://dx.doi.org/urn:doi:10.2147/JAA.S142200
Access Level:acceso abierto
Palabra clave:Asthma
Mucins
Inflammation
Induced sputum
Toll-like receptor
id ES_e15303fd2ca245fcc258a247c2cefa15
oai_identifier_str oai:ddd.uab.cat:186365
network_acronym_str ES
network_name_str España
repository_id_str
spelling Asthma with bronchial hypersecretionexpression of mucins and toll-like receptors in sputum and bloodCrespo Lessmann, Astrid|||0000-0002-2238-6851Mateus, EderTorrejón, Montserrat|||0000-0002-0819-6066Belda Soler, AliciaGiner, Jordi|||0000-0002-3044-2059Vidal, Silvia|||0000-0002-3909-6682Sibila, Oriol|||0000-0002-4833-6713Plaza, Vicente|||0000-0003-2567-5496AsthmaMucinsInflammationInduced sputumToll-like receptor1) Define the clinical and inflammatory phenotype of asthma with bronchial hypersecretion of mucus. 2) Compare the type of mucin present in induced sputum (IS) of patients with and without bronchial hypersecretion. 3) Determine the expression of TLRs in IS and blood of asthmatics with and without bronchial hypersecretion. Cross-sectional study which included 43 non-smoking asthmatic patients without bronchiectasis, 19 with bronchiectasis, and 24 without bronchial hypersecretion. All patients underwent the following: IS, spirometry, fractional exhaled nitric oxide, prick test, total immunoglobulin E (IgE), and blood albumin. Analysis of mucins was determined by ELISA and expression of TLR2 and TLR4 by flow cytometry. The level of asthma control was determined by the Asthma Control Test (ACT) questionnaire and quality of life was assessed by the reduced version of the Asthma Quality of Life Questionnaire (mini-AQLQ). Asthmatics with bronchial hypersecretion were significantly older (62.6 years vs 48.5 years; p =0.02); had greater severity (persistent severe asthma 94.7% vs 29.2%; p =0.000); a higher proportion of nasal polyposis (36.8% vs 8.3%; p =0.022); less control of asthma (73.7% vs 8.3%; p =0,000); a higher proportion of asthma with negative prick test (68.4% vs 16.6%; p =0.001), and lower levels of IgE (113.4 IU/mL vs 448 IU/mL; p =0.007), compared with asthmatics without bronchial hypersecretion. Significant differences were observed neither in the expression of TLRs 2 and 4 in inflammatory cells of IS or peripheral blood, nor in the expression of mucins between both groups. Asthma patients with bronchial hypersecretion have more severe and uncontrolled disease, with poor quality of life as well as a non-allergic inflammatory phenotype. Within the mechanisms involving these differences, it does not appear that mucins and TLRs play an important role.Universitat Autònoma de Barcelona 22017-01-0120172017-01-01Articlehttp://purl.org/coar/resource_type/c_6501VoRhttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articleapplication/pdfhttps://ddd.uab.cat/record/186365https://dx.doi.org/urn:doi:10.2147/JAA.S142200reponame:Dipòsit Digital de Documents de la UABinstname:Universitat Autònoma de BarcelonaInglésengopen accesshttp://purl.org/coar/access_right/c_abf2Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, sempre que no sigui amb finalitats comercials, i sempre que es reconegui l'autoria de l'obra original.https://creativecommons.org/licenses/by-nc/4.0/info:eu-repo/semantics/openAccessoai:ddd.uab.cat:1863652026-06-06T12:50:31Z
dc.title.none.fl_str_mv Asthma with bronchial hypersecretion
expression of mucins and toll-like receptors in sputum and blood
title Asthma with bronchial hypersecretion
spellingShingle Asthma with bronchial hypersecretion
Crespo Lessmann, Astrid|||0000-0002-2238-6851
Asthma
Mucins
Inflammation
Induced sputum
Toll-like receptor
title_short Asthma with bronchial hypersecretion
title_full Asthma with bronchial hypersecretion
title_fullStr Asthma with bronchial hypersecretion
title_full_unstemmed Asthma with bronchial hypersecretion
title_sort Asthma with bronchial hypersecretion
dc.creator.none.fl_str_mv Crespo Lessmann, Astrid|||0000-0002-2238-6851
Mateus, Eder
Torrejón, Montserrat|||0000-0002-0819-6066
Belda Soler, Alicia
Giner, Jordi|||0000-0002-3044-2059
Vidal, Silvia|||0000-0002-3909-6682
Sibila, Oriol|||0000-0002-4833-6713
Plaza, Vicente|||0000-0003-2567-5496
author Crespo Lessmann, Astrid|||0000-0002-2238-6851
author_facet Crespo Lessmann, Astrid|||0000-0002-2238-6851
Mateus, Eder
Torrejón, Montserrat|||0000-0002-0819-6066
Belda Soler, Alicia
Giner, Jordi|||0000-0002-3044-2059
Vidal, Silvia|||0000-0002-3909-6682
Sibila, Oriol|||0000-0002-4833-6713
Plaza, Vicente|||0000-0003-2567-5496
author_role author
author2 Mateus, Eder
Torrejón, Montserrat|||0000-0002-0819-6066
Belda Soler, Alicia
Giner, Jordi|||0000-0002-3044-2059
Vidal, Silvia|||0000-0002-3909-6682
Sibila, Oriol|||0000-0002-4833-6713
Plaza, Vicente|||0000-0003-2567-5496
author2_role author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Universitat Autònoma de Barcelona
dc.subject.none.fl_str_mv Asthma
Mucins
Inflammation
Induced sputum
Toll-like receptor
topic Asthma
Mucins
Inflammation
Induced sputum
Toll-like receptor
description 1) Define the clinical and inflammatory phenotype of asthma with bronchial hypersecretion of mucus. 2) Compare the type of mucin present in induced sputum (IS) of patients with and without bronchial hypersecretion. 3) Determine the expression of TLRs in IS and blood of asthmatics with and without bronchial hypersecretion. Cross-sectional study which included 43 non-smoking asthmatic patients without bronchiectasis, 19 with bronchiectasis, and 24 without bronchial hypersecretion. All patients underwent the following: IS, spirometry, fractional exhaled nitric oxide, prick test, total immunoglobulin E (IgE), and blood albumin. Analysis of mucins was determined by ELISA and expression of TLR2 and TLR4 by flow cytometry. The level of asthma control was determined by the Asthma Control Test (ACT) questionnaire and quality of life was assessed by the reduced version of the Asthma Quality of Life Questionnaire (mini-AQLQ). Asthmatics with bronchial hypersecretion were significantly older (62.6 years vs 48.5 years; p =0.02); had greater severity (persistent severe asthma 94.7% vs 29.2%; p =0.000); a higher proportion of nasal polyposis (36.8% vs 8.3%; p =0.022); less control of asthma (73.7% vs 8.3%; p =0,000); a higher proportion of asthma with negative prick test (68.4% vs 16.6%; p =0.001), and lower levels of IgE (113.4 IU/mL vs 448 IU/mL; p =0.007), compared with asthmatics without bronchial hypersecretion. Significant differences were observed neither in the expression of TLRs 2 and 4 in inflammatory cells of IS or peripheral blood, nor in the expression of mucins between both groups. Asthma patients with bronchial hypersecretion have more severe and uncontrolled disease, with poor quality of life as well as a non-allergic inflammatory phenotype. Within the mechanisms involving these differences, it does not appear that mucins and TLRs play an important role.
publishDate 2017
dc.date.none.fl_str_mv 2
2017-01-01
2017
2017-01-01
dc.type.none.fl_str_mv Article
http://purl.org/coar/resource_type/c_6501
VoR
http://purl.org/coar/version/c_970fb48d4fbd8a85
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv https://ddd.uab.cat/record/186365
https://dx.doi.org/urn:doi:10.2147/JAA.S142200
url https://ddd.uab.cat/record/186365
https://dx.doi.org/urn:doi:10.2147/JAA.S142200
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
https://creativecommons.org/licenses/by-nc/4.0/
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
https://creativecommons.org/licenses/by-nc/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv reponame:Dipòsit Digital de Documents de la UAB
instname:Universitat Autònoma de Barcelona
instname_str Universitat Autònoma de Barcelona
reponame_str Dipòsit Digital de Documents de la UAB
collection Dipòsit Digital de Documents de la UAB
repository.name.fl_str_mv
repository.mail.fl_str_mv
_version_ 1869422282138451968
score 15.301603

Similares en LA Referencia