[Dataset] Fish oil supplementation counteracts the effect of high-fat and high-sucrose diets on the carbonylated proteome in the rat cerebral cortex

High daily intake of saturated fats and refined carbohydrates, which often leads to obesity and overweight, has been associated with cognitive impairment, premature brain aging and the aggravation of neurodegenerative diseases. Although the molecular pathology of obesity-related brain damage is not...

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Detalhes bibliográficos
Autores: Moreno, Francisco, Méndez, Lucía, Raner, Ana, Miralles-Pérez, Bernat, Romeu, Marta, Ramos-Romero, Sara, Torres, Josep Lluís, Medina, Isabel
Formato: conjunto de datos
Fecha de publicación:2023
País:España
Recursos:Consejo Superior de Investigaciones Científicas (CSIC)
Repositorio:DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:oai:digital.csic.es:10261/384329
Acesso em linha:http://hdl.handle.net/10261/384329
https://digital.csic.es/handle/10261/337722
Access Level:acceso abierto
Palavra-chave:Protein carbonylation
Cerebral cortex
High-fat and high-sucrose diet
Omega-3 fish oil
Oxidative stress
Prediabetes
http://metadata.un.org/sdg/3
Ensure healthy lives and promote well-being for all at all ages
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oai_identifier_str oai:digital.csic.es:10261/384329
network_acronym_str ES
network_name_str España
repository_id_str
dc.title.none.fl_str_mv [Dataset] Fish oil supplementation counteracts the effect of high-fat and high-sucrose diets on the carbonylated proteome in the rat cerebral cortex
title [Dataset] Fish oil supplementation counteracts the effect of high-fat and high-sucrose diets on the carbonylated proteome in the rat cerebral cortex
spellingShingle [Dataset] Fish oil supplementation counteracts the effect of high-fat and high-sucrose diets on the carbonylated proteome in the rat cerebral cortex
Moreno, Francisco
Protein carbonylation
Cerebral cortex
High-fat and high-sucrose diet
Omega-3 fish oil
Oxidative stress
Prediabetes
http://metadata.un.org/sdg/3
Ensure healthy lives and promote well-being for all at all ages
title_short [Dataset] Fish oil supplementation counteracts the effect of high-fat and high-sucrose diets on the carbonylated proteome in the rat cerebral cortex
title_full [Dataset] Fish oil supplementation counteracts the effect of high-fat and high-sucrose diets on the carbonylated proteome in the rat cerebral cortex
title_fullStr [Dataset] Fish oil supplementation counteracts the effect of high-fat and high-sucrose diets on the carbonylated proteome in the rat cerebral cortex
title_full_unstemmed [Dataset] Fish oil supplementation counteracts the effect of high-fat and high-sucrose diets on the carbonylated proteome in the rat cerebral cortex
title_sort [Dataset] Fish oil supplementation counteracts the effect of high-fat and high-sucrose diets on the carbonylated proteome in the rat cerebral cortex
dc.creator.none.fl_str_mv Moreno, Francisco
Méndez, Lucía
Raner, Ana
Miralles-Pérez, Bernat
Romeu, Marta
Ramos-Romero, Sara
Torres, Josep Lluís
Medina, Isabel
author Moreno, Francisco
author_facet Moreno, Francisco
Méndez, Lucía
Raner, Ana
Miralles-Pérez, Bernat
Romeu, Marta
Ramos-Romero, Sara
Torres, Josep Lluís
Medina, Isabel
author_role author
author2 Méndez, Lucía
Raner, Ana
Miralles-Pérez, Bernat
Romeu, Marta
Ramos-Romero, Sara
Torres, Josep Lluís
Medina, Isabel
author2_role author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Ministerio de Ciencia e Innovación (España)
0000-0002-9711-2994
0000-0003-1294-7069
Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]
dc.subject.none.fl_str_mv Protein carbonylation
Cerebral cortex
High-fat and high-sucrose diet
Omega-3 fish oil
Oxidative stress
Prediabetes
http://metadata.un.org/sdg/3
Ensure healthy lives and promote well-being for all at all ages
topic Protein carbonylation
Cerebral cortex
High-fat and high-sucrose diet
Omega-3 fish oil
Oxidative stress
Prediabetes
http://metadata.un.org/sdg/3
Ensure healthy lives and promote well-being for all at all ages
description High daily intake of saturated fats and refined carbohydrates, which often leads to obesity and overweight, has been associated with cognitive impairment, premature brain aging and the aggravation of neurodegenerative diseases. Although the molecular pathology of obesity-related brain damage is not fully understood, the increased levels of oxidative stress induced by the diet seem to be definitively involved. Being protein carbonylation determinant for protein activity and function and a main consequence of oxidative stress, this study aims to investigate the effect of the long-term high-fat and sucrose diet intake on carbonylated proteome of the cerebral cortex of Sprague-Dawley rats. To achieve this goal, the study identified and quantified the carbonylated proteins and lipid peroxidation products in the cortex, and correlated them with biometrical, biochemical and other redox status parameters. Results demonstrated that the obesogenic diet selectively increased oxidative damage of specific proteins that participate in fundamental pathways for brain function, i.e. energy production, glucose metabolism and neurotransmission. This study also evaluated the antioxidant properties of fish oil to counteract diet-induced brain oxidative damage. Fish oil supplementation demonstrated a stronger capacity to modulate carbonylated proteome in the brain cortex. Data indicated that fish oils did not just decrease carbonylation of proteins affected by the obesogenic diet, but also decreased the oxidative damage of other proteins participating in the same metabolic functions, reinforcing the beneficial effect of the supplement on those pathways. The results could help contribute to the development of successful nutritional-based interventions to prevent cognitive decline and promote brain health.
publishDate 2023
dc.date.none.fl_str_mv 2023
2025
2025
dc.type.none.fl_str_mv info:eu-repo/semantics/dataset
http://purl.org/coar/resource_type/c_ddb1
format dataset
dc.identifier.none.fl_str_mv http://hdl.handle.net/10261/384329
https://digital.csic.es/handle/10261/337722
url http://hdl.handle.net/10261/384329
https://digital.csic.es/handle/10261/337722
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv #PLACEHOLDER_PARENT_METADATA_VALUE#
info:eu-repo/grantAgreement/MCIN/AEI/ 10.13039
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie
Fish oil supplementation counteracts the effect of high-fat and high-sucrose diets on the carbonylated proteome in the rat cerebral cortex
Sí
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:DIGITAL.CSIC. Repositorio Institucional del CSIC
instname:Consejo Superior de Investigaciones Científicas (CSIC)
instname_str Consejo Superior de Investigaciones Científicas (CSIC)
reponame_str DIGITAL.CSIC. Repositorio Institucional del CSIC
collection DIGITAL.CSIC. Repositorio Institucional del CSIC
repository.name.fl_str_mv
repository.mail.fl_str_mv
_version_ 1869422279726727168
spelling [Dataset] Fish oil supplementation counteracts the effect of high-fat and high-sucrose diets on the carbonylated proteome in the rat cerebral cortexMoreno, FranciscoMéndez, LucíaRaner, AnaMiralles-Pérez, BernatRomeu, MartaRamos-Romero, SaraTorres, Josep LluísMedina, IsabelProtein carbonylationCerebral cortexHigh-fat and high-sucrose dietOmega-3 fish oilOxidative stressPrediabeteshttp://metadata.un.org/sdg/3Ensure healthy lives and promote well-being for all at all agesHigh daily intake of saturated fats and refined carbohydrates, which often leads to obesity and overweight, has been associated with cognitive impairment, premature brain aging and the aggravation of neurodegenerative diseases. Although the molecular pathology of obesity-related brain damage is not fully understood, the increased levels of oxidative stress induced by the diet seem to be definitively involved. Being protein carbonylation determinant for protein activity and function and a main consequence of oxidative stress, this study aims to investigate the effect of the long-term high-fat and sucrose diet intake on carbonylated proteome of the cerebral cortex of Sprague-Dawley rats. To achieve this goal, the study identified and quantified the carbonylated proteins and lipid peroxidation products in the cortex, and correlated them with biometrical, biochemical and other redox status parameters. Results demonstrated that the obesogenic diet selectively increased oxidative damage of specific proteins that participate in fundamental pathways for brain function, i.e. energy production, glucose metabolism and neurotransmission. This study also evaluated the antioxidant properties of fish oil to counteract diet-induced brain oxidative damage. Fish oil supplementation demonstrated a stronger capacity to modulate carbonylated proteome in the brain cortex. Data indicated that fish oils did not just decrease carbonylation of proteins affected by the obesogenic diet, but also decreased the oxidative damage of other proteins participating in the same metabolic functions, reinforcing the beneficial effect of the supplement on those pathways. The results could help contribute to the development of successful nutritional-based interventions to prevent cognitive decline and promote brain health.The Spanish Ministry of Science and Innovation is gratefully acknowledged for the doctoral fellowship to Francisco Moreno. Lucía Méndez acknowledges the postdoctoral financial support received from AEI within the Juan de la Cierva Spanish Postdoctoral Program (IJC2020–046017-I/MCIN/AEI/ 10.13039/501100011033 and “NextGenerationEU”/PRTR”) and Xunta de Galicia—Axencia Galega de Innovación (GAIN) (IN606C2021/003). Ana Raner gratefully acknowledge to the EIT Food RIS Fellowships 2020. Bernat Miralles-P é rez acknowledges the postdoctoral financial support received from the Ministry of Universities and the Recovery, Transformation and Resilience Plan funded by the European Union–NextGenerationEU (2021URV-MS-15) and the doctoral financial support received from the Secretariat of Universities and Research of the Government of Catalonia, the European Union, and the European Social Fund (2018 FI_B 00919, 2019 FI_B1 00160, 2020 FI_B2 00119). The authors thank Lorena Barros and Vanessa Sánchez-Martos for their excellent technical assistance. The authors gratefully acknowledge to AFAMSA (Vigo, Spain) for generously provide the fish oils.Peer reviewedElsevierMinisterio de Ciencia e Innovación (España)0000-0002-9711-29940000-0003-1294-7069Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]202520252023info:eu-repo/semantics/datasethttp://purl.org/coar/resource_type/c_ddb1http://hdl.handle.net/10261/384329https://digital.csic.es/handle/10261/337722reponame:DIGITAL.CSIC. Repositorio Institucional del CSICinstname:Consejo Superior de Investigaciones Científicas (CSIC)Inglés#PLACEHOLDER_PARENT_METADATA_VALUE#info:eu-repo/grantAgreement/MCIN/AEI/ 10.13039Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapieFish oil supplementation counteracts the effect of high-fat and high-sucrose diets on the carbonylated proteome in the rat cerebral cortexSíinfo:eu-repo/semantics/openAccessoai:digital.csic.es:10261/3843292026-05-22T06:33:51Z
score 15,811543

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