Decidua-derived mesenchymal stem cells as carriers of mesoporous silica nanoparticles. In vitro and in vivo evaluation on mammary tumors

The potential use of human Decidua-derived mesenchymal stem cells (DMSCs) as a platform to carry mesoporous silica nanoparticles in cancer therapy has been investigated. Two types of nanoparticles were evaluated. The nanoparticles showed negligible toxicity to the cells, a fast uptake and a long ret...

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Detalles Bibliográficos
Autores: Paris, Juan L., Torre, Paz de la, Manzano, Miguel, Cabañas Criado, María Victoria, Flores, Ana I., Vallet Regí, María Dulce Nombre
Tipo de recurso: artículo
Fecha de publicación:2016
País:España
Institución:Universidad Complutense de Madrid (UCM)
Repositorio:Docta Complutense
Idioma:español
OAI Identifier:oai:docta.ucm.es:20.500.14352/23180
Acceso en línea:https://hdl.handle.net/20.500.14352/23180
Access Level:acceso abierto
Palabra clave:66
546
615.46
Nanoparticles
Mesoporous silica
Nanomedicine
Human decidua-derived mesenchymal stem cells
Materiales
Química inorgánica (Química)
3312 Tecnología de Materiales
2303 Química Inorgánica
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oai_identifier_str oai:docta.ucm.es:20.500.14352/23180
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network_name_str España
repository_id_str
spelling Decidua-derived mesenchymal stem cells as carriers of mesoporous silica nanoparticles. In vitro and in vivo evaluation on mammary tumorsParis, Juan L.Torre, Paz de laManzano, MiguelCabañas Criado, María VictoriaFlores, Ana I.Vallet Regí, María Dulce Nombre66546615.46NanoparticlesMesoporous silicaNanomedicineHuman decidua-derived mesenchymal stem cellsMaterialesQuímica inorgánica (Química)3312 Tecnología de Materiales2303 Química InorgánicaThe potential use of human Decidua-derived mesenchymal stem cells (DMSCs) as a platform to carry mesoporous silica nanoparticles in cancer therapy has been investigated. Two types of nanoparticles were evaluated. The nanoparticles showed negligible toxicity to the cells, a fast uptake and a long retention inside them. Nanoparticle location in the cell was studied by colocalization with the lysosomes. Moreover, the in vitro and in vivo migration of DMSCs towards tumors was not modified by the evaluated nanoparticles. Finally, DMSCs transporting doxorubicin-loaded nanoparticles were capable of inducing cancer cell death in vitro.ElsevierUniversidad Complutense de Madrid20162016-03-1520162016-03-15journal articlehttp://purl.org/coar/resource_type/c_6501info:eu-repo/semantics/articleapplication/pdfhttps://hdl.handle.net/20.500.14352/23180reponame:Docta Complutenseinstname:Universidad Complutense de Madrid (UCM)Españolspaopen accesshttp://purl.org/coar/access_right/c_abf2info:eu-repo/semantics/openAccessoai:docta.ucm.es:20.500.14352/231802026-06-02T12:44:21Z
dc.title.none.fl_str_mv Decidua-derived mesenchymal stem cells as carriers of mesoporous silica nanoparticles. In vitro and in vivo evaluation on mammary tumors
title Decidua-derived mesenchymal stem cells as carriers of mesoporous silica nanoparticles. In vitro and in vivo evaluation on mammary tumors
spellingShingle Decidua-derived mesenchymal stem cells as carriers of mesoporous silica nanoparticles. In vitro and in vivo evaluation on mammary tumors
Paris, Juan L.
66
546
615.46
Nanoparticles
Mesoporous silica
Nanomedicine
Human decidua-derived mesenchymal stem cells
Materiales
Química inorgánica (Química)
3312 Tecnología de Materiales
2303 Química Inorgánica
title_short Decidua-derived mesenchymal stem cells as carriers of mesoporous silica nanoparticles. In vitro and in vivo evaluation on mammary tumors
title_full Decidua-derived mesenchymal stem cells as carriers of mesoporous silica nanoparticles. In vitro and in vivo evaluation on mammary tumors
title_fullStr Decidua-derived mesenchymal stem cells as carriers of mesoporous silica nanoparticles. In vitro and in vivo evaluation on mammary tumors
title_full_unstemmed Decidua-derived mesenchymal stem cells as carriers of mesoporous silica nanoparticles. In vitro and in vivo evaluation on mammary tumors
title_sort Decidua-derived mesenchymal stem cells as carriers of mesoporous silica nanoparticles. In vitro and in vivo evaluation on mammary tumors
dc.creator.none.fl_str_mv Paris, Juan L.
Torre, Paz de la
Manzano, Miguel
Cabañas Criado, María Victoria
Flores, Ana I.
Vallet Regí, María Dulce Nombre
author Paris, Juan L.
author_facet Paris, Juan L.
Torre, Paz de la
Manzano, Miguel
Cabañas Criado, María Victoria
Flores, Ana I.
Vallet Regí, María Dulce Nombre
author_role author
author2 Torre, Paz de la
Manzano, Miguel
Cabañas Criado, María Victoria
Flores, Ana I.
Vallet Regí, María Dulce Nombre
author2_role author
author
author
author
author
dc.contributor.none.fl_str_mv Universidad Complutense de Madrid
dc.subject.none.fl_str_mv 66
546
615.46
Nanoparticles
Mesoporous silica
Nanomedicine
Human decidua-derived mesenchymal stem cells
Materiales
Química inorgánica (Química)
3312 Tecnología de Materiales
2303 Química Inorgánica
topic 66
546
615.46
Nanoparticles
Mesoporous silica
Nanomedicine
Human decidua-derived mesenchymal stem cells
Materiales
Química inorgánica (Química)
3312 Tecnología de Materiales
2303 Química Inorgánica
description The potential use of human Decidua-derived mesenchymal stem cells (DMSCs) as a platform to carry mesoporous silica nanoparticles in cancer therapy has been investigated. Two types of nanoparticles were evaluated. The nanoparticles showed negligible toxicity to the cells, a fast uptake and a long retention inside them. Nanoparticle location in the cell was studied by colocalization with the lysosomes. Moreover, the in vitro and in vivo migration of DMSCs towards tumors was not modified by the evaluated nanoparticles. Finally, DMSCs transporting doxorubicin-loaded nanoparticles were capable of inducing cancer cell death in vitro.
publishDate 2016
dc.date.none.fl_str_mv 2016
2016-03-15
2016
2016-03-15
dc.type.none.fl_str_mv journal article
http://purl.org/coar/resource_type/c_6501
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv https://hdl.handle.net/20.500.14352/23180
url https://hdl.handle.net/20.500.14352/23180
dc.language.none.fl_str_mv Español
spa
language_invalid_str_mv Español
language spa
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:Docta Complutense
instname:Universidad Complutense de Madrid (UCM)
instname_str Universidad Complutense de Madrid (UCM)
reponame_str Docta Complutense
collection Docta Complutense
repository.name.fl_str_mv
repository.mail.fl_str_mv
_version_ 1869422278576439296
score 15,300724

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