Population genomics in the great apes
The great apes play an important role as model organisms. They are our closest living relatives, allowing us to identify the genetic basis of phenotypic traits that we think of as characteristically human. However, the most significant asset of great apes as model organisms is that they share with h...
| Autores: | , |
|---|---|
| Tipo de recurso: | artículo |
| Estado: | Versión publicada |
| Fecha de publicación: | 2020 |
| País: | España |
| Institución: | Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya) |
| Repositorio: | Recercat. Dipósit de la Recerca de Catalunya |
| OAI Identifier: | oai:recercat.cat:10230/44434 |
| Acceso en línea: | http://hdl.handle.net/10230/44434 http://dx.doi.org/10.1007/978-1-0716-0199-0_19 |
| Access Level: | acceso abierto |
| Palabra clave: | Genètica Genòmica Genoma humà Homínids |
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Population genomics in the great apesCastellano Esteve, DavidMunch, KasperGenèticaGenòmicaGenoma humàHomínidsThe great apes play an important role as model organisms. They are our closest living relatives, allowing us to identify the genetic basis of phenotypic traits that we think of as characteristically human. However, the most significant asset of great apes as model organisms is that they share with humans most of their genetic makeup. This means that we can extend our vast knowledge of the human genome, its genes, and the associated phenotypes to these species. Comparative genomic studies of humans and apes thus reveal how very similar genomes react when exposed to different population genetic regimes. In this way, each species represents a natural experiment, where a genome highly similar to the human one, is differently exposed to the evolutionary forces of demography, population structure, selection, recombination, and admixture/hybridization. The initial sequencing of reference genomes for chimpanzee, orangutan, gorilla, the bonobo, each provided new insights and a second generation of sequencing projects has provided diversity data for all the great apes. In this chapter, we will outline some of the findings that population genomic analysis of great apes has provided, and how comparative studies have helped us understand how the fundamental forces in evolution have contributed to shaping the genomes and the genetic diversity of the great apes.Humana Press (Springer Imprint)202020202020info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfapplication/pdfhttp://hdl.handle.net/10230/44434http://dx.doi.org/10.1007/978-1-0716-0199-0_19reponame:Recercat. Dipósit de la Recerca de Catalunyainstname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)InglésMethods in Molecular Biology. 2020;2090:453-63© 2020 David Castellano and Kasper Munch. Open Access. This article is licensed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license and indicate if changes were madehttp://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:recercat.cat:10230/444342026-05-29T05:05:01Z |
| dc.title.none.fl_str_mv |
Population genomics in the great apes |
| title |
Population genomics in the great apes |
| spellingShingle |
Population genomics in the great apes Castellano Esteve, David Genètica Genòmica Genoma humà Homínids |
| title_short |
Population genomics in the great apes |
| title_full |
Population genomics in the great apes |
| title_fullStr |
Population genomics in the great apes |
| title_full_unstemmed |
Population genomics in the great apes |
| title_sort |
Population genomics in the great apes |
| dc.creator.none.fl_str_mv |
Castellano Esteve, David Munch, Kasper |
| author |
Castellano Esteve, David |
| author_facet |
Castellano Esteve, David Munch, Kasper |
| author_role |
author |
| author2 |
Munch, Kasper |
| author2_role |
author |
| dc.subject.none.fl_str_mv |
Genètica Genòmica Genoma humà Homínids |
| topic |
Genètica Genòmica Genoma humà Homínids |
| description |
The great apes play an important role as model organisms. They are our closest living relatives, allowing us to identify the genetic basis of phenotypic traits that we think of as characteristically human. However, the most significant asset of great apes as model organisms is that they share with humans most of their genetic makeup. This means that we can extend our vast knowledge of the human genome, its genes, and the associated phenotypes to these species. Comparative genomic studies of humans and apes thus reveal how very similar genomes react when exposed to different population genetic regimes. In this way, each species represents a natural experiment, where a genome highly similar to the human one, is differently exposed to the evolutionary forces of demography, population structure, selection, recombination, and admixture/hybridization. The initial sequencing of reference genomes for chimpanzee, orangutan, gorilla, the bonobo, each provided new insights and a second generation of sequencing projects has provided diversity data for all the great apes. In this chapter, we will outline some of the findings that population genomic analysis of great apes has provided, and how comparative studies have helped us understand how the fundamental forces in evolution have contributed to shaping the genomes and the genetic diversity of the great apes. |
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2020 |
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2020 2020 2020 |
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info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
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article |
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publishedVersion |
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http://hdl.handle.net/10230/44434 http://dx.doi.org/10.1007/978-1-0716-0199-0_19 |
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http://hdl.handle.net/10230/44434 http://dx.doi.org/10.1007/978-1-0716-0199-0_19 |
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Inglés |
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Inglés |
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Methods in Molecular Biology. 2020;2090:453-63 |
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http://creativecommons.org/licenses/by/4.0/ info:eu-repo/semantics/openAccess |
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http://creativecommons.org/licenses/by/4.0/ |
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openAccess |
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application/pdf application/pdf |
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Humana Press (Springer Imprint) |
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Humana Press (Springer Imprint) |
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