Sensitivity of cervical cytology in endometrial cancer detection in a tertiary hospital in Spain

Introduction: Cervical cytology is a well-stablished cervical cancer screening method. However, due to the anatomical continuity of the genital tract, it can also detect signs of endometrial disease. Our aim was to estimate the sensitivity of cervical cytology in endometrial cancer detection and pro...

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Autores: Frias-Gomez, Jon, Tovar, Eva, Vidal, August, Murgui, Lluís, Ibáñez, Raquel, Peremiquel Trillas, Paula, Paytubi, Sonia, Baixeras, Nuria, Zanca, Alba, Ponce, Jordi, Pineda, Marta, Brunet, Joan, Sanjosé, Silvia de, BOSCH JOSÉ, FRANCESC XAVIER, Matias Guiu, Xavier, Alemany, Laia, Costas, Laura
Tipo de documento: artigo
Estado:Versão publicada
Data de publicação:2021
País:España
Recursos:Universitat Oberta de Catalunya (UOC)
Repositório:O2, repositorio institucional de la UOC
OAI Identifier:oai:openaccess.uoc.edu:10609/137006
Acesso em linha:https://hdl.handle.net/10609/137006
https://doi.org/10.1002/cam4.4217
Access Level:Acceso aberto
Palavra-chave:cervical cytology
cervico-vaginal cytology
endometrial cancer
sensitivity
papillomaviruses
papil·lomavirus
papilomavirus
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network_acronym_str ES
network_name_str España
repository_id_str
spelling Sensitivity of cervical cytology in endometrial cancer detection in a tertiary hospital in SpainFrias-Gomez, JonTovar, EvaVidal, AugustMurgui, LluísIbáñez, RaquelPeremiquel Trillas, PaulaPaytubi, SoniaBaixeras, NuriaZanca, AlbaPonce, JordiPineda, MartaBrunet, JoanSanjosé, Silvia deBOSCH JOSÉ, FRANCESC XAVIERMatias Guiu, XavierAlemany, LaiaCostas, Lauracervical cytologycervico-vaginal cytologyendometrial cancersensitivitypapillomavirusespapil·lomaviruspapilomavirusIntroduction: Cervical cytology is a well-stablished cervical cancer screening method. However, due to the anatomical continuity of the genital tract, it can also detect signs of endometrial disease. Our aim was to estimate the sensitivity of cervical cytology in endometrial cancer detection and prognosis in a large population over a 30-year period in a large academic tertiary hospital in Spain. Methodology: We performed a search for women diagnosed with endometrial cancer from 1990 to 2020, who were surgically treated and had a previous cervical cytology result. Information Technologies Department databases from Bellvitge University Hospital and the Screenwide case¿control study's database were used. Cervical cytology results were classified as abnormal when squamous lesions, glandular atypia or malignant cells were identified. Results: Overall, we evaluated 371 women with endometrial cancer and a documented cervical cytology performed within 3 years previous to surgical treatment. Overall, the sensitivity of cervical cytology for endometrial cancer detection was 25.6%. Several clinico-pathological characteristics, such as non-endometrioid histology and a higher stage, were correlated with higher sensitivity. Discussion: We observed a low sensitivity of cervical cytology to effectively diagnose endometrial cancer. However, recent technological advances using genomics and epigenomics may offer a promising perspective to detect endometrial cancer with high sensitivity in these cervical specimens.Cancer MedicineUniversitat Oberta de Catalunya (UOC)Screenwide Team202220222021info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfapplication/pdfhttps://hdl.handle.net/10609/137006https://doi.org/10.1002/cam4.4217reponame:O2, repositorio institucional de la UOCinstname:Universitat Oberta de Catalunya (UOC)Inglés10;19CC BY 4.0http://creativecommons.org/licenses/by/4.0info:eu-repo/semantics/openAccessoai:openaccess.uoc.edu:10609/1370062026-05-28T12:42:01Z
dc.title.none.fl_str_mv Sensitivity of cervical cytology in endometrial cancer detection in a tertiary hospital in Spain
title Sensitivity of cervical cytology in endometrial cancer detection in a tertiary hospital in Spain
spellingShingle Sensitivity of cervical cytology in endometrial cancer detection in a tertiary hospital in Spain
Frias-Gomez, Jon
cervical cytology
cervico-vaginal cytology
endometrial cancer
sensitivity
papillomaviruses
papil·lomavirus
papilomavirus
title_short Sensitivity of cervical cytology in endometrial cancer detection in a tertiary hospital in Spain
title_full Sensitivity of cervical cytology in endometrial cancer detection in a tertiary hospital in Spain
title_fullStr Sensitivity of cervical cytology in endometrial cancer detection in a tertiary hospital in Spain
title_full_unstemmed Sensitivity of cervical cytology in endometrial cancer detection in a tertiary hospital in Spain
title_sort Sensitivity of cervical cytology in endometrial cancer detection in a tertiary hospital in Spain
dc.creator.none.fl_str_mv Frias-Gomez, Jon
Tovar, Eva
Vidal, August
Murgui, Lluís
Ibáñez, Raquel
Peremiquel Trillas, Paula
Paytubi, Sonia
Baixeras, Nuria
Zanca, Alba
Ponce, Jordi
Pineda, Marta
Brunet, Joan
Sanjosé, Silvia de
BOSCH JOSÉ, FRANCESC XAVIER
Matias Guiu, Xavier
Alemany, Laia
Costas, Laura
author Frias-Gomez, Jon
author_facet Frias-Gomez, Jon
Tovar, Eva
Vidal, August
Murgui, Lluís
Ibáñez, Raquel
Peremiquel Trillas, Paula
Paytubi, Sonia
Baixeras, Nuria
Zanca, Alba
Ponce, Jordi
Pineda, Marta
Brunet, Joan
Sanjosé, Silvia de
BOSCH JOSÉ, FRANCESC XAVIER
Matias Guiu, Xavier
Alemany, Laia
Costas, Laura
author_role author
author2 Tovar, Eva
Vidal, August
Murgui, Lluís
Ibáñez, Raquel
Peremiquel Trillas, Paula
Paytubi, Sonia
Baixeras, Nuria
Zanca, Alba
Ponce, Jordi
Pineda, Marta
Brunet, Joan
Sanjosé, Silvia de
BOSCH JOSÉ, FRANCESC XAVIER
Matias Guiu, Xavier
Alemany, Laia
Costas, Laura
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Universitat Oberta de Catalunya (UOC)
Screenwide Team
dc.subject.none.fl_str_mv cervical cytology
cervico-vaginal cytology
endometrial cancer
sensitivity
papillomaviruses
papil·lomavirus
papilomavirus
topic cervical cytology
cervico-vaginal cytology
endometrial cancer
sensitivity
papillomaviruses
papil·lomavirus
papilomavirus
description Introduction: Cervical cytology is a well-stablished cervical cancer screening method. However, due to the anatomical continuity of the genital tract, it can also detect signs of endometrial disease. Our aim was to estimate the sensitivity of cervical cytology in endometrial cancer detection and prognosis in a large population over a 30-year period in a large academic tertiary hospital in Spain. Methodology: We performed a search for women diagnosed with endometrial cancer from 1990 to 2020, who were surgically treated and had a previous cervical cytology result. Information Technologies Department databases from Bellvitge University Hospital and the Screenwide case¿control study's database were used. Cervical cytology results were classified as abnormal when squamous lesions, glandular atypia or malignant cells were identified. Results: Overall, we evaluated 371 women with endometrial cancer and a documented cervical cytology performed within 3 years previous to surgical treatment. Overall, the sensitivity of cervical cytology for endometrial cancer detection was 25.6%. Several clinico-pathological characteristics, such as non-endometrioid histology and a higher stage, were correlated with higher sensitivity. Discussion: We observed a low sensitivity of cervical cytology to effectively diagnose endometrial cancer. However, recent technological advances using genomics and epigenomics may offer a promising perspective to detect endometrial cancer with high sensitivity in these cervical specimens.
publishDate 2021
dc.date.none.fl_str_mv 2021
2022
2022
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/10609/137006
https://doi.org/10.1002/cam4.4217
url https://hdl.handle.net/10609/137006
https://doi.org/10.1002/cam4.4217
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv 10;19
dc.rights.none.fl_str_mv CC BY 4.0
http://creativecommons.org/licenses/by/4.0
info:eu-repo/semantics/openAccess
rights_invalid_str_mv CC BY 4.0
http://creativecommons.org/licenses/by/4.0
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Cancer Medicine
publisher.none.fl_str_mv Cancer Medicine
dc.source.none.fl_str_mv reponame:O2, repositorio institucional de la UOC
instname:Universitat Oberta de Catalunya (UOC)
instname_str Universitat Oberta de Catalunya (UOC)
reponame_str O2, repositorio institucional de la UOC
collection O2, repositorio institucional de la UOC
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,300719

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