Alignment between glioblastoma internal clock and environmental cues ameliorates survival in Drosophila

Virtually every single living organism on Earth shows a circadian (i.e. “approximately a day”) internal rhythm that is coordinated with planet rotation (i.e. 24 hours). External cues synchronize the central clock of the organism. Consequences of biological rhythm disruptions have been extensively st...

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Detalles Bibliográficos
Autores: Jarabo, Patricia, Barredo, Celia G., Pablo, Carmen de, Casas-Tinto, Sergio, Martín, Francisco A.
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2022
País:España
Institución:Consejo Superior de Investigaciones Científicas (CSIC)
Repositorio:DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:oai:digital.csic.es:10261/279353
Acceso en línea:http://hdl.handle.net/10261/279353
Access Level:acceso abierto
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spelling Alignment between glioblastoma internal clock and environmental cues ameliorates survival in DrosophilaJarabo, PatriciaBarredo, Celia G.Pablo, Carmen deCasas-Tinto, SergioMartín, Francisco A.Virtually every single living organism on Earth shows a circadian (i.e. “approximately a day”) internal rhythm that is coordinated with planet rotation (i.e. 24 hours). External cues synchronize the central clock of the organism. Consequences of biological rhythm disruptions have been extensively studied on cancer. Still, mechanisms underlying these alterations, and how they favor tumor development remain largely unknown. Here, we show that glioblastoma-induced neurodegeneration also causes circadian alterations in Drosophila. Preventing neurodegeneration in all neurons by genetic means reestablishes normal biological rhythms. Interestingly, in early stages of tumor development, the central pacemaker lengthens its period, whereas in later stages this is severely disrupted. The re-adjustment of the external light:dark period to longer glioblastoma-induced internal rhythms delays glioblastoma progression and ameliorates associated deleterious effects, even after the tumor onset.The authors thank E. Beckwith, A. Ferrús, M. Milán, and members of the Cajal Fly hub for comments on the manuscript. We also appreciate flies and reagents from F. Rouyer, N. Romero, J. Botas, R. Read, and the Bloomington and VDRC stock centers. We would like to thank the FlyBase for its wealth of information. We acknowledge the support of the Confocal Microscopy unit and Molecular Biology unit at the Cajal Institute. We want to thank the continuous support from Emirates Khalifa Capital to this project and to P.J. This work was supported by the Spanish Research Agency (MICINN) under the grant PGC2018-094630-B-I00 to S.C.T. and grant PGC2018-094630-B-100 to F.A.M., cofinanced by the European Regional Development Fund (ERDF). F.A.M. is a recipient of a Ramon y Cajal contract (2014-14961). C.G.B. is a recipient of a FPU predoctoral fellowship (FPU19/04449 -MEFP-)Nature Publishing GroupCSIC - Instituto Cajal (IC)Ministerio de Ciencia e Innovación (España)European CommissionConsejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]2022202220222022info:eu-repo/semantics/articlehttp://purl.org/coar/resource_type/c_6501Publisher's versioninfo:eu-repo/semantics/publishedVersionhttp://hdl.handle.net/10261/279353reponame:DIGITAL.CSIC. Repositorio Institucional del CSICinstname:Consejo Superior de Investigaciones Científicas (CSIC)Inglés#PLACEHOLDER_PARENT_METADATA_VALUE##PLACEHOLDER_PARENT_METADATA_VALUE#info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/PGC2018-094630-B-I00info:eu-repo/grantAgreement/MINECO//RYC-2014-14961http://dx.doi.org/10.1038/s42003-022-03600-9Síinfo:eu-repo/semantics/openAccessoai:digital.csic.es:10261/2793532026-05-22T06:33:51Z
dc.title.none.fl_str_mv Alignment between glioblastoma internal clock and environmental cues ameliorates survival in Drosophila
title Alignment between glioblastoma internal clock and environmental cues ameliorates survival in Drosophila
spellingShingle Alignment between glioblastoma internal clock and environmental cues ameliorates survival in Drosophila
Jarabo, Patricia
title_short Alignment between glioblastoma internal clock and environmental cues ameliorates survival in Drosophila
title_full Alignment between glioblastoma internal clock and environmental cues ameliorates survival in Drosophila
title_fullStr Alignment between glioblastoma internal clock and environmental cues ameliorates survival in Drosophila
title_full_unstemmed Alignment between glioblastoma internal clock and environmental cues ameliorates survival in Drosophila
title_sort Alignment between glioblastoma internal clock and environmental cues ameliorates survival in Drosophila
dc.creator.none.fl_str_mv Jarabo, Patricia
Barredo, Celia G.
Pablo, Carmen de
Casas-Tinto, Sergio
Martín, Francisco A.
author Jarabo, Patricia
author_facet Jarabo, Patricia
Barredo, Celia G.
Pablo, Carmen de
Casas-Tinto, Sergio
Martín, Francisco A.
author_role author
author2 Barredo, Celia G.
Pablo, Carmen de
Casas-Tinto, Sergio
Martín, Francisco A.
author2_role author
author
author
author
dc.contributor.none.fl_str_mv CSIC - Instituto Cajal (IC)
Ministerio de Ciencia e Innovación (España)
European Commission
Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]
description Virtually every single living organism on Earth shows a circadian (i.e. “approximately a day”) internal rhythm that is coordinated with planet rotation (i.e. 24 hours). External cues synchronize the central clock of the organism. Consequences of biological rhythm disruptions have been extensively studied on cancer. Still, mechanisms underlying these alterations, and how they favor tumor development remain largely unknown. Here, we show that glioblastoma-induced neurodegeneration also causes circadian alterations in Drosophila. Preventing neurodegeneration in all neurons by genetic means reestablishes normal biological rhythms. Interestingly, in early stages of tumor development, the central pacemaker lengthens its period, whereas in later stages this is severely disrupted. The re-adjustment of the external light:dark period to longer glioblastoma-induced internal rhythms delays glioblastoma progression and ameliorates associated deleterious effects, even after the tumor onset.
publishDate 2022
dc.date.none.fl_str_mv 2022
2022
2022
2022
dc.type.none.fl_str_mv info:eu-repo/semantics/article
http://purl.org/coar/resource_type/c_6501
Publisher's version
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10261/279353
url http://hdl.handle.net/10261/279353
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv #PLACEHOLDER_PARENT_METADATA_VALUE#
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info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/PGC2018-094630-B-I00
info:eu-repo/grantAgreement/MINECO//RYC-2014-14961
http://dx.doi.org/10.1038/s42003-022-03600-9
Sí
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Nature Publishing Group
publisher.none.fl_str_mv Nature Publishing Group
dc.source.none.fl_str_mv reponame:DIGITAL.CSIC. Repositorio Institucional del CSIC
instname:Consejo Superior de Investigaciones Científicas (CSIC)
instname_str Consejo Superior de Investigaciones Científicas (CSIC)
reponame_str DIGITAL.CSIC. Repositorio Institucional del CSIC
collection DIGITAL.CSIC. Repositorio Institucional del CSIC
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