Increased inflammation, oxidative stress and mitochondrial respiration in brown adipose tissue from obese mice

Obesity is associated with severe metabolic diseases such as type 2 diabetes, insulin resistance, cardiovascular disease and some forms of cancer. The pathophysiology of obesity-induced metabolic diseases has been strongly related to white adipose tissue (WAT) dysfunction through several mechanisms...

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Authors: Alcalá, Martín, Calderón Domínguez, María, Bustos Araya, Marta Eduviges, Ramos, Pilar, Casals i Farré, Núria, Serra i Cucurull, Dolors, Viana Arribas, Marta, Herrero Rodríguez, Laura
Format: article
Status:Published version
Publication Date:2017
Country:España
Institution:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Repository:Recercat. Dipósit de la Recerca de Catalunya
OAI Identifier:oai:recercat.cat:2445/119455
Online Access:https://hdl.handle.net/2445/119455
Access Level:Open access
Keyword:Obesitat
Teixit adipós
Estrès oxidatiu
Inflamació
Mitocondris
Obesity
Adipose tissues
Oxidative stress
Inflammation
Mitochondria
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spelling Increased inflammation, oxidative stress and mitochondrial respiration in brown adipose tissue from obese miceAlcalá, MartínCalderón Domínguez, MaríaBustos Araya, Marta EduvigesRamos, PilarCasals i Farré, NúriaSerra i Cucurull, DolorsViana Arribas, MartaHerrero Rodríguez, LauraObesitatTeixit adipósEstrès oxidatiuInflamacióMitocondrisObesityAdipose tissuesOxidative stressInflammationMitochondriaObesity is associated with severe metabolic diseases such as type 2 diabetes, insulin resistance, cardiovascular disease and some forms of cancer. The pathophysiology of obesity-induced metabolic diseases has been strongly related to white adipose tissue (WAT) dysfunction through several mechanisms such as fibrosis, apoptosis, inflammation, ER and oxidative stress. However, little is known of whether these processes are also present in brown adipose tissue (BAT) during obesity, and the potential consequences on mitochondrial activity. Here we characterized the BAT of obese and hyperglycemic mice treated with a high-fat diet (HFD) for 20 weeks. The hypertrophic BAT from obese mice showed no signs of fibrosis nor apoptosis, but higher levels of inflammation, ER stress, ROS generation and antioxidant enzyme activity than the lean counterparts. The response was attenuated compared with obesity-induced WAT derangements, which suggests that BAT is more resistant to the obesity-induced insult. In fact, mitochondrial respiration in BAT from obese mice was enhanced, with a 2-fold increase in basal oxygen consumption, through the upregulation of complex III of the electron transport chain and UCP1. Altogether, our results show that obesity is accompanied by an increase in BAT mitochondrial activity, inflammation and oxidative damage.Nature Publishing Group2018201820172018info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersion12 p.application/pdfhttps://hdl.handle.net/2445/119455Articles publicats en revistes (Bioquímica i Fisiologia)reponame:Recercat. Dipósit de la Recerca de Catalunyainstname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)InglésReproducció del document publicat a: https://doi.org/10.1038/s41598-017-16463-6Scientific Reports, 2017, vol. 7, num. 1, p. 16082https://doi.org/10.1038/s41598-017-16463-6cc-by (c) Alcalá, Martín et al., 2017http://creativecommons.org/licenses/by/3.0/esinfo:eu-repo/semantics/openAccessoai:recercat.cat:2445/1194552026-05-29T05:05:01Z
dc.title.none.fl_str_mv Increased inflammation, oxidative stress and mitochondrial respiration in brown adipose tissue from obese mice
title Increased inflammation, oxidative stress and mitochondrial respiration in brown adipose tissue from obese mice
spellingShingle Increased inflammation, oxidative stress and mitochondrial respiration in brown adipose tissue from obese mice
Alcalá, Martín
Obesitat
Teixit adipós
Estrès oxidatiu
Inflamació
Mitocondris
Obesity
Adipose tissues
Oxidative stress
Inflammation
Mitochondria
title_short Increased inflammation, oxidative stress and mitochondrial respiration in brown adipose tissue from obese mice
title_full Increased inflammation, oxidative stress and mitochondrial respiration in brown adipose tissue from obese mice
title_fullStr Increased inflammation, oxidative stress and mitochondrial respiration in brown adipose tissue from obese mice
title_full_unstemmed Increased inflammation, oxidative stress and mitochondrial respiration in brown adipose tissue from obese mice
title_sort Increased inflammation, oxidative stress and mitochondrial respiration in brown adipose tissue from obese mice
dc.creator.none.fl_str_mv Alcalá, Martín
Calderón Domínguez, María
Bustos Araya, Marta Eduviges
Ramos, Pilar
Casals i Farré, Núria
Serra i Cucurull, Dolors
Viana Arribas, Marta
Herrero Rodríguez, Laura
author Alcalá, Martín
author_facet Alcalá, Martín
Calderón Domínguez, María
Bustos Araya, Marta Eduviges
Ramos, Pilar
Casals i Farré, Núria
Serra i Cucurull, Dolors
Viana Arribas, Marta
Herrero Rodríguez, Laura
author_role author
author2 Calderón Domínguez, María
Bustos Araya, Marta Eduviges
Ramos, Pilar
Casals i Farré, Núria
Serra i Cucurull, Dolors
Viana Arribas, Marta
Herrero Rodríguez, Laura
author2_role author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Obesitat
Teixit adipós
Estrès oxidatiu
Inflamació
Mitocondris
Obesity
Adipose tissues
Oxidative stress
Inflammation
Mitochondria
topic Obesitat
Teixit adipós
Estrès oxidatiu
Inflamació
Mitocondris
Obesity
Adipose tissues
Oxidative stress
Inflammation
Mitochondria
description Obesity is associated with severe metabolic diseases such as type 2 diabetes, insulin resistance, cardiovascular disease and some forms of cancer. The pathophysiology of obesity-induced metabolic diseases has been strongly related to white adipose tissue (WAT) dysfunction through several mechanisms such as fibrosis, apoptosis, inflammation, ER and oxidative stress. However, little is known of whether these processes are also present in brown adipose tissue (BAT) during obesity, and the potential consequences on mitochondrial activity. Here we characterized the BAT of obese and hyperglycemic mice treated with a high-fat diet (HFD) for 20 weeks. The hypertrophic BAT from obese mice showed no signs of fibrosis nor apoptosis, but higher levels of inflammation, ER stress, ROS generation and antioxidant enzyme activity than the lean counterparts. The response was attenuated compared with obesity-induced WAT derangements, which suggests that BAT is more resistant to the obesity-induced insult. In fact, mitochondrial respiration in BAT from obese mice was enhanced, with a 2-fold increase in basal oxygen consumption, through the upregulation of complex III of the electron transport chain and UCP1. Altogether, our results show that obesity is accompanied by an increase in BAT mitochondrial activity, inflammation and oxidative damage.
publishDate 2017
dc.date.none.fl_str_mv 2017
2018
2018
2018
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/2445/119455
url https://hdl.handle.net/2445/119455
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Reproducció del document publicat a: https://doi.org/10.1038/s41598-017-16463-6
Scientific Reports, 2017, vol. 7, num. 1, p. 16082
https://doi.org/10.1038/s41598-017-16463-6
dc.rights.none.fl_str_mv cc-by (c) Alcalá, Martín et al., 2017
http://creativecommons.org/licenses/by/3.0/es
info:eu-repo/semantics/openAccess
rights_invalid_str_mv cc-by (c) Alcalá, Martín et al., 2017
http://creativecommons.org/licenses/by/3.0/es
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 12 p.
application/pdf
dc.publisher.none.fl_str_mv Nature Publishing Group
publisher.none.fl_str_mv Nature Publishing Group
dc.source.none.fl_str_mv Articles publicats en revistes (Bioquímica i Fisiologia)
reponame:Recercat. Dipósit de la Recerca de Catalunya
instname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
instname_str Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
reponame_str Recercat. Dipósit de la Recerca de Catalunya
collection Recercat. Dipósit de la Recerca de Catalunya
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,81155

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