REM sleep microarchitecture in adolescent major depressive disorder

Available online on 30th March, 2026.

Detalhes bibliográficos
Autores: Baena, D., Legault, G., Ray, L.B., Lopez, J., Hoffman, R., Robillard, R., Armitage, R., Fogel, S.M.
Tipo de documento: artigo
Data de publicação:2026
País:España
Recursos:Universidad del País Vasco
Repositório:Addi. Archivo Digital para la Docencia y la Investigación
OAI Identifier:oai:dnet:addi________::88e6b81ead20e66941b7552a96c826be
Acesso em linha:http://hdl.handle.net/10810/79054
Access Level:Acceso aberto
Palavra-chave:Sleep
REM
Phasic
Tonic
Major depressive disorder
Adolescents
Depression
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spelling REM sleep microarchitecture in adolescent major depressive disorderBaena, D.Legault, G.Ray, L.B.Lopez, J.Hoffman, R.Robillard, R.Armitage, R.Fogel, S.M.SleepREMPhasicTonicMajor depressive disorderAdolescentsDepressionAvailable online on 30th March, 2026.Rapid eye movement (REM) sleep abnormalities in adolescents with major depressive disorder (MDD) remain poorly characterized. Although previous work has reported altered eye-movement density and burst dynamics, findings are inconsistent, and few studies have examined the distinct phasic and tonic microstates of REM sleep, each defined by unique neurophysiological signatures. Here, we investigated REM microarchitecture and its association with depressive symptom change using a sleep delay challenge (SDC), an experimental paradigm that delays bedtime by three hours while maintaining total sleep time. This manipulation extends REM sleep duration and shortens REM sleep latency, providing a controlled framework to assess REM regulation. Adolescents with MDD (n = 66) and healthy controls (n = 62) underwent polysomnography across three nights: adaptation, baseline, and SDC. MDD participants exhibited longer phasic REM duration but reduced burst intensity and density relative to controls, along with higher tonic eye-movement density. Only the MDD group showed SDC-related increases in theta–alpha activity time-locked to eye movements over frontal and parietal sites. Within the MDD group, shorter phasic REM duration, higher burst intensity, and lower tonic eye-movement density predicted greater improvement in depressive symptoms following the SDC. These findings suggest that REM microarchitecture, marked by shorter, more intense phasic bursts and reduced tonic eye-movement activity, underlies individual variability in the short-term change in depressive symptom severity response to sleep delay.This study was funded by grants at the University of Michigan (RO1-MH077744 to R.A.; UL1TR000433 to Shanley T.P.; UL1 RR024986 post-doctoral fellowship to J.L.) and proceeds from donations to The Ottawa Hospital Sleep Walk fund.Elsevier202620262026info:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10810/79054reponame:Addi. Archivo Digital para la Docencia y la Investigacióninstname:Universidad del País VascoIngléshttps://www.sciencedirect.com/journal/journal-of-affective-disordersinfo:eu-repo/semantics/openAccesshttp://creativecommons.org/licenses/bync- nd/4.0/© 2026 The Authors. Published by Elsevier B.V. This is an open access article under the CC BY-NC-ND license.oai:dnet:addi________::88e6b81ead20e66941b7552a96c826be2026-06-18T09:23:17Z
dc.title.none.fl_str_mv REM sleep microarchitecture in adolescent major depressive disorder
title REM sleep microarchitecture in adolescent major depressive disorder
spellingShingle REM sleep microarchitecture in adolescent major depressive disorder
Baena, D.
Sleep
REM
Phasic
Tonic
Major depressive disorder
Adolescents
Depression
title_short REM sleep microarchitecture in adolescent major depressive disorder
title_full REM sleep microarchitecture in adolescent major depressive disorder
title_fullStr REM sleep microarchitecture in adolescent major depressive disorder
title_full_unstemmed REM sleep microarchitecture in adolescent major depressive disorder
title_sort REM sleep microarchitecture in adolescent major depressive disorder
dc.creator.none.fl_str_mv Baena, D.
Legault, G.
Ray, L.B.
Lopez, J.
Hoffman, R.
Robillard, R.
Armitage, R.
Fogel, S.M.
author Baena, D.
author_facet Baena, D.
Legault, G.
Ray, L.B.
Lopez, J.
Hoffman, R.
Robillard, R.
Armitage, R.
Fogel, S.M.
author_role author
author2 Legault, G.
Ray, L.B.
Lopez, J.
Hoffman, R.
Robillard, R.
Armitage, R.
Fogel, S.M.
author2_role author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Sleep
REM
Phasic
Tonic
Major depressive disorder
Adolescents
Depression
topic Sleep
REM
Phasic
Tonic
Major depressive disorder
Adolescents
Depression
description Available online on 30th March, 2026.
publishDate 2026
dc.date.none.fl_str_mv 2026
2026
2026
dc.type.none.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv http://hdl.handle.net/10810/79054
url http://hdl.handle.net/10810/79054
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv https://www.sciencedirect.com/journal/journal-of-affective-disorders
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
http://creativecommons.org/licenses/bync- nd/4.0/
eu_rights_str_mv openAccess
rights_invalid_str_mv http://creativecommons.org/licenses/bync- nd/4.0/
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:Addi. Archivo Digital para la Docencia y la Investigación
instname:Universidad del País Vasco
instname_str Universidad del País Vasco
reponame_str Addi. Archivo Digital para la Docencia y la Investigación
collection Addi. Archivo Digital para la Docencia y la Investigación
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,811543

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