Isolation, identification, and activity evaluation of antioxidant components from Inula viscosa: A bioguided approach

Oxidative stress is linked to several invasive diseases which causes significant clinical and economic impact, therefore, there is a need to develop new antioxidants. The natural products could play an important role in overcoming the current need. In the present work, the antioxidant bioassay-guide...

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Authors: Zeouk, Ikrame, Sifaoui, Ines, Ben Jalloul, Amel, Bekhti, Khadija, López Bazzocchi, Isabel, Piñero Barroso, José Enrique, Jiménez Díaz, Ignacio Antonio, Lorenzo Morales, Jacob
Format: article
Status:Published version
Publication Date:2022
Country:España
Institution:Universidad de La Laguna (ULL)
Repository:RIULL. Repositorio Institucional de la Universidad de La Laguna
OAI Identifier:oai:riull.ull.es:915/35927
Online Access:http://riull.ull.es/xmlui/handle/915/35927
Access Level:Open access
Keyword:Bioguided fractionation
Inula viscosa
Taxifolin
Quercetin
Antioxidants
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spelling Isolation, identification, and activity evaluation of antioxidant components from Inula viscosa: A bioguided approachZeouk, IkrameSifaoui, InesBen Jalloul, AmelBekhti, KhadijaLópez Bazzocchi, IsabelPiñero Barroso, José EnriqueJiménez Díaz, Ignacio AntonioLorenzo Morales, JacobBioguided fractionationInula viscosaTaxifolinQuercetinAntioxidantsOxidative stress is linked to several invasive diseases which causes significant clinical and economic impact, therefore, there is a need to develop new antioxidants. The natural products could play an important role in overcoming the current need. In the present work, the antioxidant bioassay-guided fractionation of the ethanolic extract of Inula viscosa leaves (Asteraceae) was performed using DPPH and ABTS assays affording three known compounds, which were successfully characterized as ilicic acid (1), taxifolin (2) and quercetin (3) based on 1D, 2D NMR. Compounds 2 and 3 were identified as the most active, displaying similar or higher potency against ABTS (value 41.27 for quercetin and 142.58 for taxifolin) and similar activity against DPPH (value 41.27 for quercetin and 142.58 for taxifolin) than the well-known reference, ascorbic acid (value 65.36 for quercetin and 58.43 for taxifolin) but less potency than the standard gallic acid. The discussion of SAR of the antioxidant potential revealed that the type of natural product is crucial for the activity and the substitution pattern on the flavonoid skeleton modulate the antioxidant profile. Our findings show that I. viscosa leaves may be a natural source of antioxidants and once again the role of flavonoids health benefits is more strongly endorsed.202420242022info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://riull.ull.es/xmlui/handle/915/35927reponame:RIULL. Repositorio Institucional de la Universidad de La Lagunainstname:Universidad de La Laguna (ULL)InglésBioorganic Chemistry 119 (2022) 105551;Attribution-NonCommercial-NoDerivatives 4.0 Internacionalhttp://creativecommons.org/licenses/by-nc-nd/4.0/info:eu-repo/semantics/openAccessoai:riull.ull.es:915/359272026-06-22T13:13:57Z
dc.title.none.fl_str_mv Isolation, identification, and activity evaluation of antioxidant components from Inula viscosa: A bioguided approach
title Isolation, identification, and activity evaluation of antioxidant components from Inula viscosa: A bioguided approach
spellingShingle Isolation, identification, and activity evaluation of antioxidant components from Inula viscosa: A bioguided approach
Zeouk, Ikrame
Bioguided fractionation
Inula viscosa
Taxifolin
Quercetin
Antioxidants
title_short Isolation, identification, and activity evaluation of antioxidant components from Inula viscosa: A bioguided approach
title_full Isolation, identification, and activity evaluation of antioxidant components from Inula viscosa: A bioguided approach
title_fullStr Isolation, identification, and activity evaluation of antioxidant components from Inula viscosa: A bioguided approach
title_full_unstemmed Isolation, identification, and activity evaluation of antioxidant components from Inula viscosa: A bioguided approach
title_sort Isolation, identification, and activity evaluation of antioxidant components from Inula viscosa: A bioguided approach
dc.creator.none.fl_str_mv Zeouk, Ikrame
Sifaoui, Ines
Ben Jalloul, Amel
Bekhti, Khadija
López Bazzocchi, Isabel
Piñero Barroso, José Enrique
Jiménez Díaz, Ignacio Antonio
Lorenzo Morales, Jacob
author Zeouk, Ikrame
author_facet Zeouk, Ikrame
Sifaoui, Ines
Ben Jalloul, Amel
Bekhti, Khadija
López Bazzocchi, Isabel
Piñero Barroso, José Enrique
Jiménez Díaz, Ignacio Antonio
Lorenzo Morales, Jacob
author_role author
author2 Sifaoui, Ines
Ben Jalloul, Amel
Bekhti, Khadija
López Bazzocchi, Isabel
Piñero Barroso, José Enrique
Jiménez Díaz, Ignacio Antonio
Lorenzo Morales, Jacob
author2_role author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Bioguided fractionation
Inula viscosa
Taxifolin
Quercetin
Antioxidants
topic Bioguided fractionation
Inula viscosa
Taxifolin
Quercetin
Antioxidants
description Oxidative stress is linked to several invasive diseases which causes significant clinical and economic impact, therefore, there is a need to develop new antioxidants. The natural products could play an important role in overcoming the current need. In the present work, the antioxidant bioassay-guided fractionation of the ethanolic extract of Inula viscosa leaves (Asteraceae) was performed using DPPH and ABTS assays affording three known compounds, which were successfully characterized as ilicic acid (1), taxifolin (2) and quercetin (3) based on 1D, 2D NMR. Compounds 2 and 3 were identified as the most active, displaying similar or higher potency against ABTS (value 41.27 for quercetin and 142.58 for taxifolin) and similar activity against DPPH (value 41.27 for quercetin and 142.58 for taxifolin) than the well-known reference, ascorbic acid (value 65.36 for quercetin and 58.43 for taxifolin) but less potency than the standard gallic acid. The discussion of SAR of the antioxidant potential revealed that the type of natural product is crucial for the activity and the substitution pattern on the flavonoid skeleton modulate the antioxidant profile. Our findings show that I. viscosa leaves may be a natural source of antioxidants and once again the role of flavonoids health benefits is more strongly endorsed.
publishDate 2022
dc.date.none.fl_str_mv 2022
2024
2024
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://riull.ull.es/xmlui/handle/915/35927
url http://riull.ull.es/xmlui/handle/915/35927
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Bioorganic Chemistry 119 (2022) 105551;
dc.rights.none.fl_str_mv Attribution-NonCommercial-NoDerivatives 4.0 Internacional
http://creativecommons.org/licenses/by-nc-nd/4.0/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv Attribution-NonCommercial-NoDerivatives 4.0 Internacional
http://creativecommons.org/licenses/by-nc-nd/4.0/
eu_rights_str_mv openAccess
dc.source.none.fl_str_mv reponame:RIULL. Repositorio Institucional de la Universidad de La Laguna
instname:Universidad de La Laguna (ULL)
instname_str Universidad de La Laguna (ULL)
reponame_str RIULL. Repositorio Institucional de la Universidad de La Laguna
collection RIULL. Repositorio Institucional de la Universidad de La Laguna
repository.name.fl_str_mv
repository.mail.fl_str_mv
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