The Effect of a Mediterranean Diet on the Incidence of Cataract Surgery
BACKGROUND: Cataract is a leading cause of vision impairment worldwide, and surgery is the only available treatment. The process that initiates lens opacification is dependent on the oxidative stress experienced by the lens components. A healthy overall dietary pattern, with the potential to reduce...
| Autores: | , , , , , , , , , , , , , , , , , , , |
|---|---|
| Formato: | artículo |
| Estado: | Versión publicada |
| Fecha de publicación: | 2017 |
| País: | España |
| Recursos: | Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya) |
| Repositorio: | Recercat. Dipósit de la Recerca de Catalunya |
| OAI Identifier: | oai:recercat.cat:10230/35037 |
| Acesso em linha: | http://hdl.handle.net/10230/35037 http://dx.doi.org/10.3390/nu9050453 |
| Access Level: | acceso abierto |
| Palavra-chave: | Cataractes -- Cirugia Dieta mediterrània Mediterranean diet PREDIMED Antioxidants Cataract Cataract surgery Extra-virgin olive oil Low-fat diet Nuts |
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The Effect of a Mediterranean Diet on the Incidence of Cataract SurgeryGarcía-Layana, AlfredoGianfranco, CiufoToledo, EstefaniaMartínez-González, Miguel Ángel, 1957-Corella, DoloresFitó Colomer, MontserratEstruch, RamónGómez-Gracia, EnriqueFiol, MiquelLapetra, JoséSerra-Majem, LuisPinto, XavierPortillo, María P.Sorlí, José VicenteBulló, MònicaVinyoles, ErnestSala Vila, AleixRos, EmilioSalas-Salvadó, JordiArós, FernandoCataractes -- CirugiaDieta mediterràniaMediterranean dietPREDIMEDAntioxidantsCataractCataract surgeryExtra-virgin olive oilLow-fat dietNutsBACKGROUND: Cataract is a leading cause of vision impairment worldwide, and surgery is the only available treatment. The process that initiates lens opacification is dependent on the oxidative stress experienced by the lens components. A healthy overall dietary pattern, with the potential to reduce oxidative stress, has been suggested as a means to decrease the risk of developing cataract. We aimed to investigate the hypothesis that an intervention with a Mediterranean diet (MedDiet) rather than a low-fat diet could decrease the incidence of cataract surgery in elderly subjects. METHODS: We included 5802 men and women (age range: 55-80 years) from the Prevención con Dieta Mediterránea study (multicenter, parallel-group, randomized controlled clinical trial) who had not undergone cataract surgery. They were randomly assigned to one of three intervention groups: (1) a MedDiet enriched with extra-virgin olive oil (EVOO) (n = 1998); (2) a MedDiet enriched with nuts (n = 1914), and a control group recommended to follow a low-fat diet (n = 1890). The incidence of cataract surgery was recorded yearly during follow-up clinical evaluations. Primary analyses were performed on an intention-to-treat basis. Cox regression analyses were used to assess the relationship between the nutritional intervention and the incidence of cataract surgery. RESULTS: During a follow-up period of 7.0 years (mean follow-up period: 5.7 years; median: 5.9 years), 559 subjects underwent cataract surgery. Two hundred and six participants from the MedDiet + EVOO group, 174 from the MedDiet + Nuts group, and 179 from the control group underwent cataract surgery. We did not observe a reduction in the incidence of cataract surgery in the MedDiet groups compared to the control group. The multivariable adjusted hazard ratios were 1.03 (95% confidence interval [CI]: 0.84-1.26, p = 0.79) for the control group versus the MedDiet + EVOO group and 1.06 (95% CI: 0.86-1.31, p = 0.58) for the control group versus the MedDiet + Nuts group. CONCLUSIONS: To our knowledge, this is the first large randomized trial assessing the role of a MedDiet on the incidence of cataract surgery. Our results showed that the incidence of cataract surgery was similar in the MedDiet with EVOO, MedDiet with nuts, and low-fat diet groups. Further studies are necessary to investigate whether a MedDiet could have a preventive role in cataract surgery.MDPI201820182017info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfapplication/pdfhttp://hdl.handle.net/10230/35037http://dx.doi.org/10.3390/nu9050453reponame:Recercat. Dipósit de la Recerca de Catalunyainstname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)InglésNutrients. 2017 May 3;9(5):E453Copyright © 2017 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).http://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:recercat.cat:10230/350372026-05-29T05:05:01Z |
| dc.title.none.fl_str_mv |
The Effect of a Mediterranean Diet on the Incidence of Cataract Surgery |
| title |
The Effect of a Mediterranean Diet on the Incidence of Cataract Surgery |
| spellingShingle |
The Effect of a Mediterranean Diet on the Incidence of Cataract Surgery García-Layana, Alfredo Cataractes -- Cirugia Dieta mediterrània Mediterranean diet PREDIMED Antioxidants Cataract Cataract surgery Extra-virgin olive oil Low-fat diet Nuts |
| title_short |
The Effect of a Mediterranean Diet on the Incidence of Cataract Surgery |
| title_full |
The Effect of a Mediterranean Diet on the Incidence of Cataract Surgery |
| title_fullStr |
The Effect of a Mediterranean Diet on the Incidence of Cataract Surgery |
| title_full_unstemmed |
The Effect of a Mediterranean Diet on the Incidence of Cataract Surgery |
| title_sort |
The Effect of a Mediterranean Diet on the Incidence of Cataract Surgery |
| dc.creator.none.fl_str_mv |
García-Layana, Alfredo Gianfranco, Ciufo Toledo, Estefania Martínez-González, Miguel Ángel, 1957- Corella, Dolores Fitó Colomer, Montserrat Estruch, Ramón Gómez-Gracia, Enrique Fiol, Miquel Lapetra, José Serra-Majem, Luis Pinto, Xavier Portillo, María P. Sorlí, José Vicente Bulló, Mònica Vinyoles, Ernest Sala Vila, Aleix Ros, Emilio Salas-Salvadó, Jordi Arós, Fernando |
| author |
García-Layana, Alfredo |
| author_facet |
García-Layana, Alfredo Gianfranco, Ciufo Toledo, Estefania Martínez-González, Miguel Ángel, 1957- Corella, Dolores Fitó Colomer, Montserrat Estruch, Ramón Gómez-Gracia, Enrique Fiol, Miquel Lapetra, José Serra-Majem, Luis Pinto, Xavier Portillo, María P. Sorlí, José Vicente Bulló, Mònica Vinyoles, Ernest Sala Vila, Aleix Ros, Emilio Salas-Salvadó, Jordi Arós, Fernando |
| author_role |
author |
| author2 |
Gianfranco, Ciufo Toledo, Estefania Martínez-González, Miguel Ángel, 1957- Corella, Dolores Fitó Colomer, Montserrat Estruch, Ramón Gómez-Gracia, Enrique Fiol, Miquel Lapetra, José Serra-Majem, Luis Pinto, Xavier Portillo, María P. Sorlí, José Vicente Bulló, Mònica Vinyoles, Ernest Sala Vila, Aleix Ros, Emilio Salas-Salvadó, Jordi Arós, Fernando |
| author2_role |
author author author author author author author author author author author author author author author author author author author |
| dc.subject.none.fl_str_mv |
Cataractes -- Cirugia Dieta mediterrània Mediterranean diet PREDIMED Antioxidants Cataract Cataract surgery Extra-virgin olive oil Low-fat diet Nuts |
| topic |
Cataractes -- Cirugia Dieta mediterrània Mediterranean diet PREDIMED Antioxidants Cataract Cataract surgery Extra-virgin olive oil Low-fat diet Nuts |
| description |
BACKGROUND: Cataract is a leading cause of vision impairment worldwide, and surgery is the only available treatment. The process that initiates lens opacification is dependent on the oxidative stress experienced by the lens components. A healthy overall dietary pattern, with the potential to reduce oxidative stress, has been suggested as a means to decrease the risk of developing cataract. We aimed to investigate the hypothesis that an intervention with a Mediterranean diet (MedDiet) rather than a low-fat diet could decrease the incidence of cataract surgery in elderly subjects. METHODS: We included 5802 men and women (age range: 55-80 years) from the Prevención con Dieta Mediterránea study (multicenter, parallel-group, randomized controlled clinical trial) who had not undergone cataract surgery. They were randomly assigned to one of three intervention groups: (1) a MedDiet enriched with extra-virgin olive oil (EVOO) (n = 1998); (2) a MedDiet enriched with nuts (n = 1914), and a control group recommended to follow a low-fat diet (n = 1890). The incidence of cataract surgery was recorded yearly during follow-up clinical evaluations. Primary analyses were performed on an intention-to-treat basis. Cox regression analyses were used to assess the relationship between the nutritional intervention and the incidence of cataract surgery. RESULTS: During a follow-up period of 7.0 years (mean follow-up period: 5.7 years; median: 5.9 years), 559 subjects underwent cataract surgery. Two hundred and six participants from the MedDiet + EVOO group, 174 from the MedDiet + Nuts group, and 179 from the control group underwent cataract surgery. We did not observe a reduction in the incidence of cataract surgery in the MedDiet groups compared to the control group. The multivariable adjusted hazard ratios were 1.03 (95% confidence interval [CI]: 0.84-1.26, p = 0.79) for the control group versus the MedDiet + EVOO group and 1.06 (95% CI: 0.86-1.31, p = 0.58) for the control group versus the MedDiet + Nuts group. CONCLUSIONS: To our knowledge, this is the first large randomized trial assessing the role of a MedDiet on the incidence of cataract surgery. Our results showed that the incidence of cataract surgery was similar in the MedDiet with EVOO, MedDiet with nuts, and low-fat diet groups. Further studies are necessary to investigate whether a MedDiet could have a preventive role in cataract surgery. |
| publishDate |
2017 |
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2017 2018 2018 |
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info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
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article |
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publishedVersion |
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http://hdl.handle.net/10230/35037 http://dx.doi.org/10.3390/nu9050453 |
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http://hdl.handle.net/10230/35037 http://dx.doi.org/10.3390/nu9050453 |
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Inglés |
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Inglés |
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Nutrients. 2017 May 3;9(5):E453 |
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http://creativecommons.org/licenses/by/4.0/ info:eu-repo/semantics/openAccess |
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http://creativecommons.org/licenses/by/4.0/ |
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openAccess |
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MDPI |
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MDPI |
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