Relationship of Diet to Gut Microbiota and Inflammatory Biomarkers in People with HIV

While changes in microbiome composition have been associated with HIV, the effect of diet and its potential impact on inflammation remains unclear. Methods: Twenty-seven people living with HIV (PWH) on antiretroviral therapy (ART) were studied. A comprehensive dietary analysis was performed and two...

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Detalhes bibliográficos
Autores: Manzano, Mónica, Talavera Rodríguez, Alba, Moreno, Elena, Madrid, Nadia, Gosalbes, María José, Ron, Raquel, Dronda, Fernando, Pérez Molina, José A., Lanza, Val F., Díaz, Jorge, Moreno, Santiago, Navia, Beatriz, Serrano Villar, Sergio
Formato: artículo
Fecha de publicación:2022
País:España
Recursos:Universidad Complutense de Madrid (UCM)
Repositorio:Docta Complutense
Idioma:inglés
OAI Identifier:oai:docta.ucm.es:20.500.14352/72524
Acesso em linha:https://hdl.handle.net/20.500.14352/72524
Access Level:acceso abierto
Palavra-chave:HIV
diet
microbiota
Lachnospira
Erysipelotrichaceae
inflammatory biomarkers
D-dimer
TNF
Endocrinología
Nutrición
3205.02 Endocrinología
3206 Ciencias de la Nutrición
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oai_identifier_str oai:docta.ucm.es:20.500.14352/72524
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network_name_str España
repository_id_str
spelling Relationship of Diet to Gut Microbiota and Inflammatory Biomarkers in People with HIVManzano, MónicaTalavera Rodríguez, AlbaMoreno, ElenaMadrid, NadiaGosalbes, María JoséRon, RaquelDronda, FernandoPérez Molina, José A.Lanza, Val F.Díaz, JorgeMoreno, SantiagoNavia, BeatrizSerrano Villar, SergioHIVdietmicrobiotaLachnospiraErysipelotrichaceaeinflammatory biomarkersD-dimerTNFEndocrinologíaNutrición3205.02 Endocrinología3206 Ciencias de la NutriciónWhile changes in microbiome composition have been associated with HIV, the effect of diet and its potential impact on inflammation remains unclear. Methods: Twenty-seven people living with HIV (PWH) on antiretroviral therapy (ART) were studied. A comprehensive dietary analysis was performed and two types of dietary patterns were determined. We explored the associations of each dietary pattern with gut microbiota and plasma inflammatory biomarkers. Results: We appreciated two dietary patterns, Mediterranean-like (MEL) and one Western-like (WEL). Compared to participants with the WEL pattern, participants with MEL pattern showed higher abundance of Lachnospira (p-value = 0.02) and lower levels of the inflammatory biomarkers D-dimer (p-value = 0.050) and soluble TNF-alpha receptor 2 (sTNFR2) (p-value = 0.049). Men who have sex with men (MSM) with MEL pattern had lower abundance of Erysipelotrichaceae (p-value < 0.001) and lower levels of D-dimer (p-value = 0.026) than MSM with WEL pattern. Conclusion: MEL pattern favours Lachnospira abundance, and protects against Erysipelotrichaceae abundance and higher levels of the inflammatory biomarkers D-dimer and sTNFR2, precursors of inflammatory processes in HIV-infected patients. Our study contributes to understanding the determinants of a healthier diet and its connections with gut microbiota and inflammation.MPDIUniversidad Complutense de Madrid20222022-03-1420222022-03-14journal articlehttp://purl.org/coar/resource_type/c_6501info:eu-repo/semantics/articleapplication/pdfhttps://hdl.handle.net/20.500.14352/72524reponame:Docta Complutenseinstname:Universidad Complutense de Madrid (UCM)Inglésengopen accesshttp://purl.org/coar/access_right/c_abf2Atribución 3.0 Españahttps://creativecommons.org/licenses/by/3.0/es/info:eu-repo/semantics/openAccessoai:docta.ucm.es:20.500.14352/725242026-06-02T12:44:21Z
dc.title.none.fl_str_mv Relationship of Diet to Gut Microbiota and Inflammatory Biomarkers in People with HIV
title Relationship of Diet to Gut Microbiota and Inflammatory Biomarkers in People with HIV
spellingShingle Relationship of Diet to Gut Microbiota and Inflammatory Biomarkers in People with HIV
Manzano, Mónica
HIV
diet
microbiota
Lachnospira
Erysipelotrichaceae
inflammatory biomarkers
D-dimer
TNF
Endocrinología
Nutrición
3205.02 Endocrinología
3206 Ciencias de la Nutrición
title_short Relationship of Diet to Gut Microbiota and Inflammatory Biomarkers in People with HIV
title_full Relationship of Diet to Gut Microbiota and Inflammatory Biomarkers in People with HIV
title_fullStr Relationship of Diet to Gut Microbiota and Inflammatory Biomarkers in People with HIV
title_full_unstemmed Relationship of Diet to Gut Microbiota and Inflammatory Biomarkers in People with HIV
title_sort Relationship of Diet to Gut Microbiota and Inflammatory Biomarkers in People with HIV
dc.creator.none.fl_str_mv Manzano, Mónica
Talavera Rodríguez, Alba
Moreno, Elena
Madrid, Nadia
Gosalbes, María José
Ron, Raquel
Dronda, Fernando
Pérez Molina, José A.
Lanza, Val F.
Díaz, Jorge
Moreno, Santiago
Navia, Beatriz
Serrano Villar, Sergio
author Manzano, Mónica
author_facet Manzano, Mónica
Talavera Rodríguez, Alba
Moreno, Elena
Madrid, Nadia
Gosalbes, María José
Ron, Raquel
Dronda, Fernando
Pérez Molina, José A.
Lanza, Val F.
Díaz, Jorge
Moreno, Santiago
Navia, Beatriz
Serrano Villar, Sergio
author_role author
author2 Talavera Rodríguez, Alba
Moreno, Elena
Madrid, Nadia
Gosalbes, María José
Ron, Raquel
Dronda, Fernando
Pérez Molina, José A.
Lanza, Val F.
Díaz, Jorge
Moreno, Santiago
Navia, Beatriz
Serrano Villar, Sergio
author2_role author
author
author
author
author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Universidad Complutense de Madrid
dc.subject.none.fl_str_mv HIV
diet
microbiota
Lachnospira
Erysipelotrichaceae
inflammatory biomarkers
D-dimer
TNF
Endocrinología
Nutrición
3205.02 Endocrinología
3206 Ciencias de la Nutrición
topic HIV
diet
microbiota
Lachnospira
Erysipelotrichaceae
inflammatory biomarkers
D-dimer
TNF
Endocrinología
Nutrición
3205.02 Endocrinología
3206 Ciencias de la Nutrición
description While changes in microbiome composition have been associated with HIV, the effect of diet and its potential impact on inflammation remains unclear. Methods: Twenty-seven people living with HIV (PWH) on antiretroviral therapy (ART) were studied. A comprehensive dietary analysis was performed and two types of dietary patterns were determined. We explored the associations of each dietary pattern with gut microbiota and plasma inflammatory biomarkers. Results: We appreciated two dietary patterns, Mediterranean-like (MEL) and one Western-like (WEL). Compared to participants with the WEL pattern, participants with MEL pattern showed higher abundance of Lachnospira (p-value = 0.02) and lower levels of the inflammatory biomarkers D-dimer (p-value = 0.050) and soluble TNF-alpha receptor 2 (sTNFR2) (p-value = 0.049). Men who have sex with men (MSM) with MEL pattern had lower abundance of Erysipelotrichaceae (p-value < 0.001) and lower levels of D-dimer (p-value = 0.026) than MSM with WEL pattern. Conclusion: MEL pattern favours Lachnospira abundance, and protects against Erysipelotrichaceae abundance and higher levels of the inflammatory biomarkers D-dimer and sTNFR2, precursors of inflammatory processes in HIV-infected patients. Our study contributes to understanding the determinants of a healthier diet and its connections with gut microbiota and inflammation.
publishDate 2022
dc.date.none.fl_str_mv 2022
2022-03-14
2022
2022-03-14
dc.type.none.fl_str_mv journal article
http://purl.org/coar/resource_type/c_6501
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv https://hdl.handle.net/20.500.14352/72524
url https://hdl.handle.net/20.500.14352/72524
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
Atribución 3.0 España
https://creativecommons.org/licenses/by/3.0/es/
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
Atribución 3.0 España
https://creativecommons.org/licenses/by/3.0/es/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv MPDI
publisher.none.fl_str_mv MPDI
dc.source.none.fl_str_mv reponame:Docta Complutense
instname:Universidad Complutense de Madrid (UCM)
instname_str Universidad Complutense de Madrid (UCM)
reponame_str Docta Complutense
collection Docta Complutense
repository.name.fl_str_mv
repository.mail.fl_str_mv
_version_ 1869422236368109568
score 15,300724

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