Hipermetilación del promotor del gen reparador hMLH1 en la patogénesis del carcinoma de células renales esporádico.

Background and objective: Epigenetic inactivation is a gene function abnormality that produces no changes in the DNA sequence, with the most frequent epigenetic alteration being hypermethylation of CpG islands in the promoter regions of the genes.

Detalhes bibliográficos
Autores: Salinas Sánchez, Antonio Santiago, Rubio del Campo, Antonio, Sánchez Sánchez, Francisco, Giménez Bachs, José Miguel, Donate Moreno, María José, García Olmo, Dolores C., Escribano Martínez, Julio
Formato: artículo
Fecha de publicación:2006
País:España
Recursos:Universidad de Castilla-La Mancha
Repositorio:RUIdeRA. Repositorio Institucional de la UCLM
OAI Identifier:oai:ruidera.uclm.es:10578/34928
Acesso em linha:https://hdl.handle.net/10578/34928
Access Level:acceso abierto
Descrição
Resumo:Background and objective: Epigenetic inactivation is a gene function abnormality that produces no changes in the DNA sequence, with the most frequent epigenetic alteration being hypermethylation of CpG islands in the promoter regions of the genes.