Electric field causes volumetric changes in the human brain

Recent longitudinal neuroimaging studies in patients with electroconvulsive therapy (ECT) suggest local effects of electric stimulation (lateralized) occur in tandem with global seizure activity (generalized). We used electric field (EF) modeling in 151 ECT treated patients with depression to determ...

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Detalles Bibliográficos
Autores: Argyelan, Miklos, Oltedal, Leif, Deng, Zhi-De, Wade, Benjamin S. C., Bikson, Marom, Joanlanne, Andrea, Sanghani, Sohag, Bartsch, Hauke, Cano Català, Marta, Dale, Anders M., Dannlowski, Udo, Dols, Annemiek, Enneking, Verena, Espinoza, Randall, Kessler, Ute, Narr, Katherine, Oedegaard, Ketil J., Oudega, Mardien L., Redlich, Ronny, Stek, Max L., Takamiya, Akihiro, Emsell, Louise, Bouckaert, Filip, Sienaert, Pascal, Pujol, Jesús, Tendolkar, Indira, Eijndhoven, Philip van, Petrides, Georgios, Malhotra, Anil K., Abbott, Christopher
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2019
País:España
Institución:Universidad de Barcelona
Repositorio:Dipòsit Digital de la UB
OAI Identifier:oai:diposit.ub.edu:2445/167278
Acceso en línea:https://hdl.handle.net/2445/167278
Access Level:acceso abierto
Palabra clave:Teràpia de xoc
Camps elèctrics
Cervell
Shock therapy
Electric fields
Brain
Descripción
Sumario:Recent longitudinal neuroimaging studies in patients with electroconvulsive therapy (ECT) suggest local effects of electric stimulation (lateralized) occur in tandem with global seizure activity (generalized). We used electric field (EF) modeling in 151 ECT treated patients with depression to determine the regional relationships between EF, unbiased longitudinal volume change, and antidepressant response across 85 brain regions. The majority of regional volumes increased significantly, and volumetric changes correlated with regional electric field (t = 3.77, df = 83, r = 0.38, p=0.0003). After controlling for nuisance variables (age, treatment number, and study site), we identified two regions (left amygdala and left hippocampus) with a strong relationship between EF and volume change (FDR corrected p<0.01). However, neither structural volume changes nor electric field was associated with antidepressant response. In summary, we showed that high electrical fields are strongly associated with robust volume changes in a dose-dependent fashion.

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