High invasiveness of pneumococcal serotypes included in the new generation of conjugate vaccines
The implementation of the seven-valent pneumococcal conjugate vaccine, PCV7, has resulted in significant changes in the pneumococcal population being carried and causing disease. We aimed to determine the invasive disease potential of serotypes causing invasive paediatric disease in the era of conju...
| Autores: | , , , , , , , |
|---|---|
| Tipo de recurso: | artículo |
| Fecha de publicación: | 2014 |
| País: | España |
| Institución: | Universidad de Navarra |
| Repositorio: | Dadun. Depósito Académico Digital de la Universidad de Navarra |
| Idioma: | inglés |
| OAI Identifier: | oai:dadun.unav.edu:10171/68849 |
| Acceso en línea: | https://hdl.handle.net/10171/68849 |
| Access Level: | acceso abierto |
| Palabra clave: | Materias Investigacion::Ciencias de la Salud Carriage Conjugate vaccines Pneumococcal disease Serotypes Streptococcus pneumoniae |
| id |
ES_e09643ec2f4a9ea73bac9ad81e16feb0 |
|---|---|
| oai_identifier_str |
oai:dadun.unav.edu:10171/68849 |
| network_acronym_str |
ES |
| network_name_str |
España |
| repository_id_str |
|
| spelling |
High invasiveness of pneumococcal serotypes included in the new generation of conjugate vaccinesdel-Amo, E. (Eva)|||/items/c2fb2019-169f-4a07-8c2a-967b2a51bacdBrotons, P. (Pedro)|||/items/f7a0dab8-85f4-46af-b718-ce8083cd53d4Monsonis, M. (Manuel)|||/items/b67a0d2c-06f0-4b7f-b12a-7bf557f3e7f3Triviño, M. (Miriam)|||/items/65a27479-7279-4a4f-a5ab-e3ad8f482cdcIñigo, M. (Melania)|||/items/e7bb3b46-f293-4564-80f1-b572b1e08920Selva, L. (Laura)|||/items/bc9e23f0-6087-4b9d-8cbe-81e9de2b4088Sa-Leao, R. (Raquel)|||/items/56b76ba9-afbb-49f2-8da0-0b467cf0bf8aMuñoz-Almagro, C. (Carmen)|||/items/92b43bc4-88f7-4313-acc9-4861f9eec4c5Materias Investigacion::Ciencias de la SaludCarriageConjugate vaccinesPneumococcal diseaseSerotypesStreptococcus pneumoniaeThe implementation of the seven-valent pneumococcal conjugate vaccine, PCV7, has resulted in significant changes in the pneumococcal population being carried and causing disease. We aimed to determine the invasive disease potential of serotypes causing invasive paediatric disease in the era of conjugate vaccines in Catalonia, Spain, and their potential coverage by the 13-valent pneumococcal conjugate vaccine, PCV13. As a secondary objective, we evaluated whether implementation of PCV7 had resulted in significant changes in the invasive disease potential of the most frequent serotypes circulating in the area. Two pneumococcal collections obtained from children admitted to the University Hospital Sant Joan de Deu (Barcelona, Spain) between 2007 and 2011 were compared: a first set of 159 invasive disease isolates, and a second set of 209 nasopharyngeal isolates recovered from healthy children admitted for minor surgery. The most common invasive serotypes were 1 (24.5%, n = 39), 19A (21.2%, n = 34), 5 (8.8%, n = 14), 7F (8.8%, n = 14) and 3 (5%, n = 8). The most common serotypes in carriage were 19A (10%, n = 21), 6C (9%, n = 19), 23B (8.1%, n = 17), 6A (7.6%, n = 16) and 19F (6.2%, n = 13). A significantly higher propensity to cause invasive disease was observed for serotypes 1, 3, 5, 7F and 19A, all of which are included in PCV13. After false-discovery-rate correction, the results were robust for serotypes 1, 5, 7F and 19A. Non-PCV13 serotypes had a low invasive disease potential. Our data reinforce the need for continuous surveillance and should encourage efforts to introduce universal vaccination with PCV13 in children in our region.European Society of Clinical Microbiology and InfectionDadun. Depósito Académico Digital Universidad de Navarra20242024-02-0620142014-01-0120142014-01-01journal articlehttp://purl.org/coar/resource_type/c_6501info:eu-repo/semantics/articleapplication/pdfhttps://hdl.handle.net/10171/68849reponame:Dadun. Depósito Académico Digital de la Universidad de Navarrainstname:Universidad de NavarraInglésengopen accesshttp://purl.org/coar/access_right/c_abf2info:eu-repo/semantics/openAccessoai:dadun.unav.edu:10171/688492026-06-21T12:47:57Z |
| dc.title.none.fl_str_mv |
High invasiveness of pneumococcal serotypes included in the new generation of conjugate vaccines |
| title |
High invasiveness of pneumococcal serotypes included in the new generation of conjugate vaccines |
| spellingShingle |
High invasiveness of pneumococcal serotypes included in the new generation of conjugate vaccines del-Amo, E. (Eva)|||/items/c2fb2019-169f-4a07-8c2a-967b2a51bacd Materias Investigacion::Ciencias de la Salud Carriage Conjugate vaccines Pneumococcal disease Serotypes Streptococcus pneumoniae |
| title_short |
High invasiveness of pneumococcal serotypes included in the new generation of conjugate vaccines |
| title_full |
High invasiveness of pneumococcal serotypes included in the new generation of conjugate vaccines |
| title_fullStr |
High invasiveness of pneumococcal serotypes included in the new generation of conjugate vaccines |
| title_full_unstemmed |
High invasiveness of pneumococcal serotypes included in the new generation of conjugate vaccines |
| title_sort |
High invasiveness of pneumococcal serotypes included in the new generation of conjugate vaccines |
| dc.creator.none.fl_str_mv |
del-Amo, E. (Eva)|||/items/c2fb2019-169f-4a07-8c2a-967b2a51bacd Brotons, P. (Pedro)|||/items/f7a0dab8-85f4-46af-b718-ce8083cd53d4 Monsonis, M. (Manuel)|||/items/b67a0d2c-06f0-4b7f-b12a-7bf557f3e7f3 Triviño, M. (Miriam)|||/items/65a27479-7279-4a4f-a5ab-e3ad8f482cdc Iñigo, M. (Melania)|||/items/e7bb3b46-f293-4564-80f1-b572b1e08920 Selva, L. (Laura)|||/items/bc9e23f0-6087-4b9d-8cbe-81e9de2b4088 Sa-Leao, R. (Raquel)|||/items/56b76ba9-afbb-49f2-8da0-0b467cf0bf8a Muñoz-Almagro, C. (Carmen)|||/items/92b43bc4-88f7-4313-acc9-4861f9eec4c5 |
| author |
del-Amo, E. (Eva)|||/items/c2fb2019-169f-4a07-8c2a-967b2a51bacd |
| author_facet |
del-Amo, E. (Eva)|||/items/c2fb2019-169f-4a07-8c2a-967b2a51bacd Brotons, P. (Pedro)|||/items/f7a0dab8-85f4-46af-b718-ce8083cd53d4 Monsonis, M. (Manuel)|||/items/b67a0d2c-06f0-4b7f-b12a-7bf557f3e7f3 Triviño, M. (Miriam)|||/items/65a27479-7279-4a4f-a5ab-e3ad8f482cdc Iñigo, M. (Melania)|||/items/e7bb3b46-f293-4564-80f1-b572b1e08920 Selva, L. (Laura)|||/items/bc9e23f0-6087-4b9d-8cbe-81e9de2b4088 Sa-Leao, R. (Raquel)|||/items/56b76ba9-afbb-49f2-8da0-0b467cf0bf8a Muñoz-Almagro, C. (Carmen)|||/items/92b43bc4-88f7-4313-acc9-4861f9eec4c5 |
| author_role |
author |
| author2 |
Brotons, P. (Pedro)|||/items/f7a0dab8-85f4-46af-b718-ce8083cd53d4 Monsonis, M. (Manuel)|||/items/b67a0d2c-06f0-4b7f-b12a-7bf557f3e7f3 Triviño, M. (Miriam)|||/items/65a27479-7279-4a4f-a5ab-e3ad8f482cdc Iñigo, M. (Melania)|||/items/e7bb3b46-f293-4564-80f1-b572b1e08920 Selva, L. (Laura)|||/items/bc9e23f0-6087-4b9d-8cbe-81e9de2b4088 Sa-Leao, R. (Raquel)|||/items/56b76ba9-afbb-49f2-8da0-0b467cf0bf8a Muñoz-Almagro, C. (Carmen)|||/items/92b43bc4-88f7-4313-acc9-4861f9eec4c5 |
| author2_role |
author author author author author author author |
| dc.contributor.none.fl_str_mv |
Dadun. Depósito Académico Digital Universidad de Navarra |
| dc.subject.none.fl_str_mv |
Materias Investigacion::Ciencias de la Salud Carriage Conjugate vaccines Pneumococcal disease Serotypes Streptococcus pneumoniae |
| topic |
Materias Investigacion::Ciencias de la Salud Carriage Conjugate vaccines Pneumococcal disease Serotypes Streptococcus pneumoniae |
| description |
The implementation of the seven-valent pneumococcal conjugate vaccine, PCV7, has resulted in significant changes in the pneumococcal population being carried and causing disease. We aimed to determine the invasive disease potential of serotypes causing invasive paediatric disease in the era of conjugate vaccines in Catalonia, Spain, and their potential coverage by the 13-valent pneumococcal conjugate vaccine, PCV13. As a secondary objective, we evaluated whether implementation of PCV7 had resulted in significant changes in the invasive disease potential of the most frequent serotypes circulating in the area. Two pneumococcal collections obtained from children admitted to the University Hospital Sant Joan de Deu (Barcelona, Spain) between 2007 and 2011 were compared: a first set of 159 invasive disease isolates, and a second set of 209 nasopharyngeal isolates recovered from healthy children admitted for minor surgery. The most common invasive serotypes were 1 (24.5%, n = 39), 19A (21.2%, n = 34), 5 (8.8%, n = 14), 7F (8.8%, n = 14) and 3 (5%, n = 8). The most common serotypes in carriage were 19A (10%, n = 21), 6C (9%, n = 19), 23B (8.1%, n = 17), 6A (7.6%, n = 16) and 19F (6.2%, n = 13). A significantly higher propensity to cause invasive disease was observed for serotypes 1, 3, 5, 7F and 19A, all of which are included in PCV13. After false-discovery-rate correction, the results were robust for serotypes 1, 5, 7F and 19A. Non-PCV13 serotypes had a low invasive disease potential. Our data reinforce the need for continuous surveillance and should encourage efforts to introduce universal vaccination with PCV13 in children in our region. |
| publishDate |
2014 |
| dc.date.none.fl_str_mv |
2014 2014-01-01 2014 2014-01-01 2024 2024-02-06 |
| dc.type.none.fl_str_mv |
journal article http://purl.org/coar/resource_type/c_6501 |
| dc.type.openaire.fl_str_mv |
info:eu-repo/semantics/article |
| format |
article |
| dc.identifier.none.fl_str_mv |
https://hdl.handle.net/10171/68849 |
| url |
https://hdl.handle.net/10171/68849 |
| dc.language.none.fl_str_mv |
Inglés eng |
| language_invalid_str_mv |
Inglés |
| language |
eng |
| dc.rights.none.fl_str_mv |
open access http://purl.org/coar/access_right/c_abf2 |
| dc.rights.openaire.fl_str_mv |
info:eu-repo/semantics/openAccess |
| rights_invalid_str_mv |
open access http://purl.org/coar/access_right/c_abf2 |
| eu_rights_str_mv |
openAccess |
| dc.format.none.fl_str_mv |
application/pdf |
| dc.publisher.none.fl_str_mv |
European Society of Clinical Microbiology and Infection |
| publisher.none.fl_str_mv |
European Society of Clinical Microbiology and Infection |
| dc.source.none.fl_str_mv |
reponame:Dadun. Depósito Académico Digital de la Universidad de Navarra instname:Universidad de Navarra |
| instname_str |
Universidad de Navarra |
| reponame_str |
Dadun. Depósito Académico Digital de la Universidad de Navarra |
| collection |
Dadun. Depósito Académico Digital de la Universidad de Navarra |
| repository.name.fl_str_mv |
|
| repository.mail.fl_str_mv |
|
| _version_ |
1869422216110669824 |
| score |
15.301629 |