Mechanisms linking excess adiposity and carcinogenesis promotion

Obesity constitutes one of the most important metabolic diseases being associated to insulin resistance development and increased cardiovascular risk. Association between obesity and cancer has also been well established for several tumor types, such as breast cancer in post-menopausal women, colore...

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Autores: Perez-Hernandez, A.I. (Ana I.)|||/items/0ded53e2-074a-4d0d-821e-f40f3ff13795, Catalán-Goñi, V. (Victoria)|||/items/9a5a055c-323a-4b41-800f-65abf7f22c79, Gomez-Ambrosi, J. (Javier)|||/items/21d09997-940a-45f7-9b4b-0a9f64b2ed8e, Rodriguez, A. (Amaia)|||/items/50976a5f-9842-47f1-8a9c-508e59996427, Frühbeck, G. (Gema)|||/items/7f0b1f72-bc91-4ab0-a3fd-21e9a3fb663b
Tipo de recurso: artículo
Fecha de publicación:2014
País:España
Institución:Universidad de Navarra
Repositorio:Dadun. Depósito Académico Digital de la Universidad de Navarra
Idioma:inglés
OAI Identifier:oai:dadun.unav.edu:10171/36209
Acceso en línea:https://hdl.handle.net/10171/36209
Access Level:acceso abierto
Palabra clave:Adipokine
Adipose tissue
Carcinogenesis
Hypoxia
Inflammation
Insulin resistance
Obesity
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spelling Mechanisms linking excess adiposity and carcinogenesis promotionPerez-Hernandez, A.I. (Ana I.)|||/items/0ded53e2-074a-4d0d-821e-f40f3ff13795Catalán-Goñi, V. (Victoria)|||/items/9a5a055c-323a-4b41-800f-65abf7f22c79Gomez-Ambrosi, J. (Javier)|||/items/21d09997-940a-45f7-9b4b-0a9f64b2ed8eRodriguez, A. (Amaia)|||/items/50976a5f-9842-47f1-8a9c-508e59996427Frühbeck, G. (Gema)|||/items/7f0b1f72-bc91-4ab0-a3fd-21e9a3fb663bAdipokineAdipose tissueCarcinogenesisHypoxiaInflammationInsulin resistanceObesityObesity constitutes one of the most important metabolic diseases being associated to insulin resistance development and increased cardiovascular risk. Association between obesity and cancer has also been well established for several tumor types, such as breast cancer in post-menopausal women, colorectal, and prostate cancer. Cancer is the first death cause in developed countries and the second one in developing countries, with high incidence rates around the world. Furthermore, it has been estimated that 15-20% of all cancer deaths may be attributable to obesity. Tumor growth is regulated by interactions between tumor cells and their tissue microenvironment. In this sense, obesity may lead to cancer development through dysfunctional adipose tissue and altered signaling pathways. In this review, three main pathways relating obesity and cancer development are examined: (i) inflammatory changes leading to macrophage polarization and altered adipokine profile; (ii) insulin resistance development; and (iii) adipose tissue hypoxia. Since obesity and cancer present a high prevalence, the association between these conditions is of great public health significance and studies showing mechanisms by which obesity lead to cancer development and progression are needed to improve prevention and management of these diseases.FrontiersDadun. Depósito Académico Digital Universidad de Navarra20142014-08-0220142014-01-0120142014-01-01journal articlehttp://purl.org/coar/resource_type/c_6501info:eu-repo/semantics/articleapplication/pdfhttps://hdl.handle.net/10171/36209reponame:Dadun. Depósito Académico Digital de la Universidad de Navarrainstname:Universidad de NavarraInglésengopen accesshttp://purl.org/coar/access_right/c_abf2info:eu-repo/semantics/openAccessoai:dadun.unav.edu:10171/362092026-06-21T12:47:57Z
dc.title.none.fl_str_mv Mechanisms linking excess adiposity and carcinogenesis promotion
title Mechanisms linking excess adiposity and carcinogenesis promotion
spellingShingle Mechanisms linking excess adiposity and carcinogenesis promotion
Perez-Hernandez, A.I. (Ana I.)|||/items/0ded53e2-074a-4d0d-821e-f40f3ff13795
Adipokine
Adipose tissue
Carcinogenesis
Hypoxia
Inflammation
Insulin resistance
Obesity
title_short Mechanisms linking excess adiposity and carcinogenesis promotion
title_full Mechanisms linking excess adiposity and carcinogenesis promotion
title_fullStr Mechanisms linking excess adiposity and carcinogenesis promotion
title_full_unstemmed Mechanisms linking excess adiposity and carcinogenesis promotion
title_sort Mechanisms linking excess adiposity and carcinogenesis promotion
dc.creator.none.fl_str_mv Perez-Hernandez, A.I. (Ana I.)|||/items/0ded53e2-074a-4d0d-821e-f40f3ff13795
Catalán-Goñi, V. (Victoria)|||/items/9a5a055c-323a-4b41-800f-65abf7f22c79
Gomez-Ambrosi, J. (Javier)|||/items/21d09997-940a-45f7-9b4b-0a9f64b2ed8e
Rodriguez, A. (Amaia)|||/items/50976a5f-9842-47f1-8a9c-508e59996427
Frühbeck, G. (Gema)|||/items/7f0b1f72-bc91-4ab0-a3fd-21e9a3fb663b
author Perez-Hernandez, A.I. (Ana I.)|||/items/0ded53e2-074a-4d0d-821e-f40f3ff13795
author_facet Perez-Hernandez, A.I. (Ana I.)|||/items/0ded53e2-074a-4d0d-821e-f40f3ff13795
Catalán-Goñi, V. (Victoria)|||/items/9a5a055c-323a-4b41-800f-65abf7f22c79
Gomez-Ambrosi, J. (Javier)|||/items/21d09997-940a-45f7-9b4b-0a9f64b2ed8e
Rodriguez, A. (Amaia)|||/items/50976a5f-9842-47f1-8a9c-508e59996427
Frühbeck, G. (Gema)|||/items/7f0b1f72-bc91-4ab0-a3fd-21e9a3fb663b
author_role author
author2 Catalán-Goñi, V. (Victoria)|||/items/9a5a055c-323a-4b41-800f-65abf7f22c79
Gomez-Ambrosi, J. (Javier)|||/items/21d09997-940a-45f7-9b4b-0a9f64b2ed8e
Rodriguez, A. (Amaia)|||/items/50976a5f-9842-47f1-8a9c-508e59996427
Frühbeck, G. (Gema)|||/items/7f0b1f72-bc91-4ab0-a3fd-21e9a3fb663b
author2_role author
author
author
author
dc.contributor.none.fl_str_mv Dadun. Depósito Académico Digital Universidad de Navarra
dc.subject.none.fl_str_mv Adipokine
Adipose tissue
Carcinogenesis
Hypoxia
Inflammation
Insulin resistance
Obesity
topic Adipokine
Adipose tissue
Carcinogenesis
Hypoxia
Inflammation
Insulin resistance
Obesity
description Obesity constitutes one of the most important metabolic diseases being associated to insulin resistance development and increased cardiovascular risk. Association between obesity and cancer has also been well established for several tumor types, such as breast cancer in post-menopausal women, colorectal, and prostate cancer. Cancer is the first death cause in developed countries and the second one in developing countries, with high incidence rates around the world. Furthermore, it has been estimated that 15-20% of all cancer deaths may be attributable to obesity. Tumor growth is regulated by interactions between tumor cells and their tissue microenvironment. In this sense, obesity may lead to cancer development through dysfunctional adipose tissue and altered signaling pathways. In this review, three main pathways relating obesity and cancer development are examined: (i) inflammatory changes leading to macrophage polarization and altered adipokine profile; (ii) insulin resistance development; and (iii) adipose tissue hypoxia. Since obesity and cancer present a high prevalence, the association between these conditions is of great public health significance and studies showing mechanisms by which obesity lead to cancer development and progression are needed to improve prevention and management of these diseases.
publishDate 2014
dc.date.none.fl_str_mv 2014
2014-08-02
2014
2014-01-01
2014
2014-01-01
dc.type.none.fl_str_mv journal article
http://purl.org/coar/resource_type/c_6501
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv https://hdl.handle.net/10171/36209
url https://hdl.handle.net/10171/36209
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Frontiers
publisher.none.fl_str_mv Frontiers
dc.source.none.fl_str_mv reponame:Dadun. Depósito Académico Digital de la Universidad de Navarra
instname:Universidad de Navarra
instname_str Universidad de Navarra
reponame_str Dadun. Depósito Académico Digital de la Universidad de Navarra
collection Dadun. Depósito Académico Digital de la Universidad de Navarra
repository.name.fl_str_mv
repository.mail.fl_str_mv
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