Molecular imaging of infarcted heart by biofunctionalized gold nanoshells
The unique combination of physical and optical properties of silica (core)/gold (shell) nanoparticles (gold nanoshells) makes them especially suitable for biomedicine. Gold nanoshells are used from high-resolution in vivo imaging to in vivo photothermal tumor treatment. Furthermore, their large scat...
| Autores: | , , , , , , , , , , , , , , , , |
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| Formato: | artículo |
| Estado: | Versión aceptada para publicación |
| Fecha de publicación: | 2021 |
| País: | España |
| Recursos: | Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya) |
| Repositorio: | Recercat. Dipósit de la Recerca de Catalunya |
| OAI Identifier: | oai:recercat.cat:10230/52746 |
| Acesso em linha: | http://hdl.handle.net/10230/52746 http://dx.doi.org/10.1002/adhm.202002186 |
| Access Level: | acceso abierto |
| Palavra-chave: | Gold nanoshells Infarctions Optical coherence tomography Surface functionalization |
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Molecular imaging of infarcted heart by biofunctionalized gold nanoshellsMuñoz-Ortiz, TamaraHu, JieOrtgies, Dirk H.Shrikhande, ShreyaZamora Pérez, Paula, 1988-Granado, MiriamGonzález-Hedström, DanielFuente-Fernández, María de laGarcía-Villalón, Ángel LuisAndrés-Delgado, LauraMartín Rodríguez, EmmaAguilar Torres, RíoAlfonso, FernandoGarcía Solé, JoséRivera Gil, Pilar, 1976-Jaque, DanielRivero, FernandoGold nanoshellsInfarctionsOptical coherence tomographySurface functionalizationThe unique combination of physical and optical properties of silica (core)/gold (shell) nanoparticles (gold nanoshells) makes them especially suitable for biomedicine. Gold nanoshells are used from high-resolution in vivo imaging to in vivo photothermal tumor treatment. Furthermore, their large scattering cross-section in the second biological window (1000-1700 nm) makes them also especially adequate for molecular optical coherence tomography (OCT). In this work, it is demonstrated that, after suitable functionalization, gold nanoshells in combination with clinical OCT systems are capable of imaging damage in the myocardium following an infarct. Since both inflammation and apoptosis are two of the main mechanisms underlying myocardial damage after ischemia, such damage imaging is achieved by endowing gold nanoshells with selective affinity for the inflammatory marker intercellular adhesion molecule 1 (ICAM-1), and the apoptotic marker phosphatidylserine. The results here presented constitute a first step toward a fast, safe, and accurate diagnosis of damaged tissue within infarcted hearts at the molecular level by means of the highly sensitive OCT interferometric technique.Wiley202220222021info:eu-repo/semantics/articleinfo:eu-repo/semantics/acceptedVersionapplication/pdfapplication/pdfhttp://hdl.handle.net/10230/52746http://dx.doi.org/10.1002/adhm.202002186reponame:Recercat. Dipósit de la Recerca de Catalunyainstname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)InglésAdv Healthc Mater. 2021 May;10(10):e2002186This is the peer reviewed version of the following article: Muñoz-Ortiz T, Hu J, Ortgies DH, Shrikhande S, Zamora-Perez P, Granado M, González-Hedström D, de la Fuente-Fernández M, García-Villalón ÁL, Andrés-Delgado L, Martín Rodríguez E, Aguilar R, Alfonso F, García Solé J, Rivera Gil P, Jaque D, Rivero F. Molecular imaging of infarcted heart by biofunctionalized gold nanoshells. Adv Healthc Mater. 2021 May;10(10):e2002186. DOI: 10.1002/adhm.202002186, which has been published in final form at http://dx.doi.org/10.1002/adhm.202002186. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions.info:eu-repo/semantics/openAccessoai:recercat.cat:10230/527462026-05-29T05:05:01Z |
| dc.title.none.fl_str_mv |
Molecular imaging of infarcted heart by biofunctionalized gold nanoshells |
| title |
Molecular imaging of infarcted heart by biofunctionalized gold nanoshells |
| spellingShingle |
Molecular imaging of infarcted heart by biofunctionalized gold nanoshells Muñoz-Ortiz, Tamara Gold nanoshells Infarctions Optical coherence tomography Surface functionalization |
| title_short |
Molecular imaging of infarcted heart by biofunctionalized gold nanoshells |
| title_full |
Molecular imaging of infarcted heart by biofunctionalized gold nanoshells |
| title_fullStr |
Molecular imaging of infarcted heart by biofunctionalized gold nanoshells |
| title_full_unstemmed |
Molecular imaging of infarcted heart by biofunctionalized gold nanoshells |
| title_sort |
Molecular imaging of infarcted heart by biofunctionalized gold nanoshells |
| dc.creator.none.fl_str_mv |
Muñoz-Ortiz, Tamara Hu, Jie Ortgies, Dirk H. Shrikhande, Shreya Zamora Pérez, Paula, 1988- Granado, Miriam González-Hedström, Daniel Fuente-Fernández, María de la García-Villalón, Ángel Luis Andrés-Delgado, Laura Martín Rodríguez, Emma Aguilar Torres, Río Alfonso, Fernando García Solé, José Rivera Gil, Pilar, 1976- Jaque, Daniel Rivero, Fernando |
| author |
Muñoz-Ortiz, Tamara |
| author_facet |
Muñoz-Ortiz, Tamara Hu, Jie Ortgies, Dirk H. Shrikhande, Shreya Zamora Pérez, Paula, 1988- Granado, Miriam González-Hedström, Daniel Fuente-Fernández, María de la García-Villalón, Ángel Luis Andrés-Delgado, Laura Martín Rodríguez, Emma Aguilar Torres, Río Alfonso, Fernando García Solé, José Rivera Gil, Pilar, 1976- Jaque, Daniel Rivero, Fernando |
| author_role |
author |
| author2 |
Hu, Jie Ortgies, Dirk H. Shrikhande, Shreya Zamora Pérez, Paula, 1988- Granado, Miriam González-Hedström, Daniel Fuente-Fernández, María de la García-Villalón, Ángel Luis Andrés-Delgado, Laura Martín Rodríguez, Emma Aguilar Torres, Río Alfonso, Fernando García Solé, José Rivera Gil, Pilar, 1976- Jaque, Daniel Rivero, Fernando |
| author2_role |
author author author author author author author author author author author author author author author author |
| dc.subject.none.fl_str_mv |
Gold nanoshells Infarctions Optical coherence tomography Surface functionalization |
| topic |
Gold nanoshells Infarctions Optical coherence tomography Surface functionalization |
| description |
The unique combination of physical and optical properties of silica (core)/gold (shell) nanoparticles (gold nanoshells) makes them especially suitable for biomedicine. Gold nanoshells are used from high-resolution in vivo imaging to in vivo photothermal tumor treatment. Furthermore, their large scattering cross-section in the second biological window (1000-1700 nm) makes them also especially adequate for molecular optical coherence tomography (OCT). In this work, it is demonstrated that, after suitable functionalization, gold nanoshells in combination with clinical OCT systems are capable of imaging damage in the myocardium following an infarct. Since both inflammation and apoptosis are two of the main mechanisms underlying myocardial damage after ischemia, such damage imaging is achieved by endowing gold nanoshells with selective affinity for the inflammatory marker intercellular adhesion molecule 1 (ICAM-1), and the apoptotic marker phosphatidylserine. The results here presented constitute a first step toward a fast, safe, and accurate diagnosis of damaged tissue within infarcted hearts at the molecular level by means of the highly sensitive OCT interferometric technique. |
| publishDate |
2021 |
| dc.date.none.fl_str_mv |
2021 2022 2022 |
| dc.type.none.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/acceptedVersion |
| format |
article |
| status_str |
acceptedVersion |
| dc.identifier.none.fl_str_mv |
http://hdl.handle.net/10230/52746 http://dx.doi.org/10.1002/adhm.202002186 |
| url |
http://hdl.handle.net/10230/52746 http://dx.doi.org/10.1002/adhm.202002186 |
| dc.language.none.fl_str_mv |
Inglés |
| language_invalid_str_mv |
Inglés |
| dc.relation.none.fl_str_mv |
Adv Healthc Mater. 2021 May;10(10):e2002186 |
| dc.rights.none.fl_str_mv |
info:eu-repo/semantics/openAccess |
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openAccess |
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application/pdf application/pdf |
| dc.publisher.none.fl_str_mv |
Wiley |
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Wiley |
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reponame:Recercat. Dipósit de la Recerca de Catalunya instname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya) |
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Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya) |
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Recercat. Dipósit de la Recerca de Catalunya |
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Recercat. Dipósit de la Recerca de Catalunya |
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