Tumor-Intrinsic Perinuclear LOXL2: Prognostic Relevance and Relationship with YAP1 Activation Status in Oral Squamous Cell Carcinoma

[Introduction]: Lysyl oxidase-like 2 (LOXL2) expression and function is frequently altered in different cancers but scarcely explored in oral squamous cell carcinoma (OSCC). This prompted us to investigate the clinical relevance of LOXL2 expression pattern in OSCC and also a possible crosstalk with...

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Detalles Bibliográficos
Autores: Rodrigo, Juan P., Moreno-Bueno, Gema, Lequerica-Fernández, Paloma, Rodríguez-Santamarta, Tania, Díaz, Eva, Prieto-Fernández, Llara, Álvarez-Teijeiro, Saúl, García-Pedrero, Juana M., Vicente, Juan Carlos de
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2024
País:España
Institución:Consejo Superior de Investigaciones Científicas (CSIC)
Repositorio:DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:oai:digital.csic.es:10261/383887
Acceso en línea:http://hdl.handle.net/10261/383887
Access Level:acceso abierto
Palabra clave:Oral squamous cell carcinoma
Lysyl oxidase-like 2
YAP1
Epithelial-mesenchymal transition
Prognosis
Descripción
Sumario:[Introduction]: Lysyl oxidase-like 2 (LOXL2) expression and function is frequently altered in different cancers but scarcely explored in oral squamous cell carcinoma (OSCC). This prompted us to investigate the clinical relevance of LOXL2 expression pattern in OSCC and also a possible crosstalk with Hippo/YAP1 pathway signaling.

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