Deciphering the Contributions of CRH Receptors in the Brain and Pituitary to Stress-Induced Inhibition of the Reproductive Axis

Based on pharmacological studies, corticotropin-releasing hormone (CRH) and its receptors play a leading role in the inhibition of the hypothalamic-pituitary-gonadal (HPG) axis during acute stress. To further study the effects of CRH receptor signaling on the HPG axis, we generated and/or employed m...

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Autores: Raftogianni, Androniki, Roth, Lena C., García-González, Diego, Bus, Thorsten, Kühne, Claudia, Monyer, Hannah, Spergel, Daniel J., Deussing, Jan M., Grinevich, Valery
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2018
País:España
Institución:Consejo Superior de Investigaciones Científicas (CSIC)
Repositorio:DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:oai:digital.csic.es:10261/379097
Acceso en línea:http://hdl.handle.net/10261/379097
https://api.elsevier.com/content/abstract/scopus_id/85054862194
Access Level:acceso abierto
Palabra clave:Stress
CRH
CRH receptors
GnRH
GnRH neurons
Gonadotropes
Reproduction
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spelling Deciphering the Contributions of CRH Receptors in the Brain and Pituitary to Stress-Induced Inhibition of the Reproductive AxisRaftogianni, AndronikiRoth, Lena C.García-González, DiegoBus, ThorstenKühne, ClaudiaMonyer, HannahSpergel, Daniel J.Deussing, Jan M.Grinevich, ValeryStressCRHCRH receptorsGnRHGnRH neuronsGonadotropesReproductionBased on pharmacological studies, corticotropin-releasing hormone (CRH) and its receptors play a leading role in the inhibition of the hypothalamic-pituitary-gonadal (HPG) axis during acute stress. To further study the effects of CRH receptor signaling on the HPG axis, we generated and/or employed male mice lacking CRH receptor type 1 (CRHR1) or type 2 (CRHR2) in gonadotropin-releasing hormone neurons, GABAergic neurons, or in all central neurons and glia. The deletion of CRHRs revealed a preserved decrease of plasma luteinizing hormone (LH) in response to either psychophysical or immunological stress. However, under basal conditions, central infusion of CRH into mice lacking CRHR1 in all central neurons and glia, or application of CRH to pituitary cultures from mice lacking CRHR2, failed to suppress LH release, unlike in controls. Our results, taken together with those of the earlier pharmacological studies, suggest that inhibition of the male HPG axis during acute stress is mediated by other factors along with CRH, and that CRH suppresses the HPG axis at the central and pituitary levels via CRHR1 and CRHR2, respectively.This work was supported by the Schaller Research Foundation (VG), the Max Planck Society (AR, LR, TB, DS, JD, and VG), and by the German Research Foundation (DFG) grant GR3619/2-1 (VG).Peer reviewedFrontiers MediaChica and Heinz Schaller FoundationMax Planck SocietyGerman Research Foundation202520252018info:eu-repo/semantics/articlehttp://purl.org/coar/resource_type/c_6501Publisher's versioninfo:eu-repo/semantics/publishedVersionapplication/pdfhttp://hdl.handle.net/10261/379097https://api.elsevier.com/content/abstract/scopus_id/85054862194reponame:DIGITAL.CSIC. Repositorio Institucional del CSICinstname:Consejo Superior de Investigaciones Científicas (CSIC)Ingléshttps://doi.org/10.3389/fnmol.2018.00305Noinfo:eu-repo/semantics/openAccessoai:digital.csic.es:10261/3790972026-05-22T06:33:51Z
dc.title.none.fl_str_mv Deciphering the Contributions of CRH Receptors in the Brain and Pituitary to Stress-Induced Inhibition of the Reproductive Axis
title Deciphering the Contributions of CRH Receptors in the Brain and Pituitary to Stress-Induced Inhibition of the Reproductive Axis
spellingShingle Deciphering the Contributions of CRH Receptors in the Brain and Pituitary to Stress-Induced Inhibition of the Reproductive Axis
Raftogianni, Androniki
Stress
CRH
CRH receptors
GnRH
GnRH neurons
Gonadotropes
Reproduction
title_short Deciphering the Contributions of CRH Receptors in the Brain and Pituitary to Stress-Induced Inhibition of the Reproductive Axis
title_full Deciphering the Contributions of CRH Receptors in the Brain and Pituitary to Stress-Induced Inhibition of the Reproductive Axis
title_fullStr Deciphering the Contributions of CRH Receptors in the Brain and Pituitary to Stress-Induced Inhibition of the Reproductive Axis
title_full_unstemmed Deciphering the Contributions of CRH Receptors in the Brain and Pituitary to Stress-Induced Inhibition of the Reproductive Axis
title_sort Deciphering the Contributions of CRH Receptors in the Brain and Pituitary to Stress-Induced Inhibition of the Reproductive Axis
dc.creator.none.fl_str_mv Raftogianni, Androniki
Roth, Lena C.
García-González, Diego
Bus, Thorsten
Kühne, Claudia
Monyer, Hannah
Spergel, Daniel J.
Deussing, Jan M.
Grinevich, Valery
author Raftogianni, Androniki
author_facet Raftogianni, Androniki
Roth, Lena C.
García-González, Diego
Bus, Thorsten
Kühne, Claudia
Monyer, Hannah
Spergel, Daniel J.
Deussing, Jan M.
Grinevich, Valery
author_role author
author2 Roth, Lena C.
García-González, Diego
Bus, Thorsten
Kühne, Claudia
Monyer, Hannah
Spergel, Daniel J.
Deussing, Jan M.
Grinevich, Valery
author2_role author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Chica and Heinz Schaller Foundation
Max Planck Society
German Research Foundation
dc.subject.none.fl_str_mv Stress
CRH
CRH receptors
GnRH
GnRH neurons
Gonadotropes
Reproduction
topic Stress
CRH
CRH receptors
GnRH
GnRH neurons
Gonadotropes
Reproduction
description Based on pharmacological studies, corticotropin-releasing hormone (CRH) and its receptors play a leading role in the inhibition of the hypothalamic-pituitary-gonadal (HPG) axis during acute stress. To further study the effects of CRH receptor signaling on the HPG axis, we generated and/or employed male mice lacking CRH receptor type 1 (CRHR1) or type 2 (CRHR2) in gonadotropin-releasing hormone neurons, GABAergic neurons, or in all central neurons and glia. The deletion of CRHRs revealed a preserved decrease of plasma luteinizing hormone (LH) in response to either psychophysical or immunological stress. However, under basal conditions, central infusion of CRH into mice lacking CRHR1 in all central neurons and glia, or application of CRH to pituitary cultures from mice lacking CRHR2, failed to suppress LH release, unlike in controls. Our results, taken together with those of the earlier pharmacological studies, suggest that inhibition of the male HPG axis during acute stress is mediated by other factors along with CRH, and that CRH suppresses the HPG axis at the central and pituitary levels via CRHR1 and CRHR2, respectively.
publishDate 2018
dc.date.none.fl_str_mv 2018
2025
2025
dc.type.none.fl_str_mv info:eu-repo/semantics/article
http://purl.org/coar/resource_type/c_6501
Publisher's version
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10261/379097
https://api.elsevier.com/content/abstract/scopus_id/85054862194
url http://hdl.handle.net/10261/379097
https://api.elsevier.com/content/abstract/scopus_id/85054862194
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv https://doi.org/10.3389/fnmol.2018.00305
No
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Frontiers Media
publisher.none.fl_str_mv Frontiers Media
dc.source.none.fl_str_mv reponame:DIGITAL.CSIC. Repositorio Institucional del CSIC
instname:Consejo Superior de Investigaciones Científicas (CSIC)
instname_str Consejo Superior de Investigaciones Científicas (CSIC)
reponame_str DIGITAL.CSIC. Repositorio Institucional del CSIC
collection DIGITAL.CSIC. Repositorio Institucional del CSIC
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15.811543

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