In vitro approaches to determine the potential carcinogenic risk of environmental pollutants
One important environmental/health challenge is to determine, in a feasible way, the potential carcinogenic risk associated with environmental agents/exposures. Since a significant proportion of tumors have an environmental origin, detecting the potential carcinogenic risk of environmental agents is...
| Autores: | , , , , , |
|---|---|
| Tipo de recurso: | artículo |
| Fecha de publicación: | 2023 |
| País: | España |
| Institución: | Universitat Autònoma de Barcelona |
| Repositorio: | Dipòsit Digital de Documents de la UAB |
| Idioma: | inglés |
| OAI Identifier: | oai:ddd.uab.cat:274511 |
| Acceso en línea: | https://ddd.uab.cat/record/274511 https://dx.doi.org/urn:doi:10.3390/ijms24097851 |
| Access Level: | acceso abierto |
| Palabra clave: | In vitro cell transformation Oncogenic phenotype Cancer hallmarks Long-term exposure |
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In vitro approaches to determine the potential carcinogenic risk of environmental pollutantsBarguilla, Irene|||0000-0003-1081-4457Maguer-Satta, Veronique|||0000-0002-1556-068XGuyot, Boris|||0000-0002-4512-7123Pastor Benito, Susana|||0000-0003-2454-5163Marcos Dauder, Ricardo|||0000-0001-7891-357XHernández Bonilla, Alba|||0000-0001-6938-1233In vitro cell transformationOncogenic phenotypeCancer hallmarksLong-term exposureOne important environmental/health challenge is to determine, in a feasible way, the potential carcinogenic risk associated with environmental agents/exposures. Since a significant proportion of tumors have an environmental origin, detecting the potential carcinogenic risk of environmental agents is mandatory, as regulated by national and international agencies. The challenge mainly implies finding a way of how to overcome the inefficiencies of long-term trials with rodents when thousands of agents/exposures need to be tested. To such an end, the use of in vitro cell transformation assays (CTAs) was proposed, but the existing prevalidated CTAs do not cover the complexity associated with carcinogenesis processes and present serious limitations. To overcome such limitations, we propose to use a battery of assays covering most of the hallmarks of the carcinogenesis process. For the first time, we grouped such assays as early, intermediate, or advanced biomarkers which allow for the identification of the cells inthe initiation, promotion or aggressive stages of tumorigenesis. Our proposal, as a novelty, points out that using a battery containing assays from all three groups can identify if a certain agent/exposure can pose a carcinogenic risk; furthermore, it can gather mechanistic insights into the mode of the action of a specific carcinogen. This structured battery could be very useful for any type of in vitro study, containing human cell lines aiming to detect the potential carcinogenic risks of environmental agents/exposures. In fact, here, we include examples in which these approaches were successfully applied. Finally, we provide a series of advantages that, we believe, contribute to the suitability of our proposed approach for the evaluation of exposure-induced carcinogenic effects and for the development of an alternative strategy for conducting an exposure risk assessment. 22023-01-0120232023-01-01Articlehttp://purl.org/coar/resource_type/c_6501VoRhttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articleapplication/pdfhttps://ddd.uab.cat/record/274511https://dx.doi.org/urn:doi:10.3390/ijms24097851reponame:Dipòsit Digital de Documents de la UABinstname:Universitat Autònoma de BarcelonaInglésengEuropean Commission https://doi.org/10.13039/501100000780 965196Agencia Estatal de Investigación https://doi.org/10.13039/501100011033 PID2020-116789RB-C43Agència de Gestió d'Ajuts Universitaris i de Recerca https://doi.org/10.13039/501100003030 2021/SGR-00731open accesshttp://purl.org/coar/access_right/c_abf2Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.https://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:ddd.uab.cat:2745112026-06-06T12:50:31Z |
| dc.title.none.fl_str_mv |
In vitro approaches to determine the potential carcinogenic risk of environmental pollutants |
| title |
In vitro approaches to determine the potential carcinogenic risk of environmental pollutants |
| spellingShingle |
In vitro approaches to determine the potential carcinogenic risk of environmental pollutants Barguilla, Irene|||0000-0003-1081-4457 In vitro cell transformation Oncogenic phenotype Cancer hallmarks Long-term exposure |
| title_short |
In vitro approaches to determine the potential carcinogenic risk of environmental pollutants |
| title_full |
In vitro approaches to determine the potential carcinogenic risk of environmental pollutants |
| title_fullStr |
In vitro approaches to determine the potential carcinogenic risk of environmental pollutants |
| title_full_unstemmed |
In vitro approaches to determine the potential carcinogenic risk of environmental pollutants |
| title_sort |
In vitro approaches to determine the potential carcinogenic risk of environmental pollutants |
| dc.creator.none.fl_str_mv |
Barguilla, Irene|||0000-0003-1081-4457 Maguer-Satta, Veronique|||0000-0002-1556-068X Guyot, Boris|||0000-0002-4512-7123 Pastor Benito, Susana|||0000-0003-2454-5163 Marcos Dauder, Ricardo|||0000-0001-7891-357X Hernández Bonilla, Alba|||0000-0001-6938-1233 |
| author |
Barguilla, Irene|||0000-0003-1081-4457 |
| author_facet |
Barguilla, Irene|||0000-0003-1081-4457 Maguer-Satta, Veronique|||0000-0002-1556-068X Guyot, Boris|||0000-0002-4512-7123 Pastor Benito, Susana|||0000-0003-2454-5163 Marcos Dauder, Ricardo|||0000-0001-7891-357X Hernández Bonilla, Alba|||0000-0001-6938-1233 |
| author_role |
author |
| author2 |
Maguer-Satta, Veronique|||0000-0002-1556-068X Guyot, Boris|||0000-0002-4512-7123 Pastor Benito, Susana|||0000-0003-2454-5163 Marcos Dauder, Ricardo|||0000-0001-7891-357X Hernández Bonilla, Alba|||0000-0001-6938-1233 |
| author2_role |
author author author author author |
| dc.subject.none.fl_str_mv |
In vitro cell transformation Oncogenic phenotype Cancer hallmarks Long-term exposure |
| topic |
In vitro cell transformation Oncogenic phenotype Cancer hallmarks Long-term exposure |
| description |
One important environmental/health challenge is to determine, in a feasible way, the potential carcinogenic risk associated with environmental agents/exposures. Since a significant proportion of tumors have an environmental origin, detecting the potential carcinogenic risk of environmental agents is mandatory, as regulated by national and international agencies. The challenge mainly implies finding a way of how to overcome the inefficiencies of long-term trials with rodents when thousands of agents/exposures need to be tested. To such an end, the use of in vitro cell transformation assays (CTAs) was proposed, but the existing prevalidated CTAs do not cover the complexity associated with carcinogenesis processes and present serious limitations. To overcome such limitations, we propose to use a battery of assays covering most of the hallmarks of the carcinogenesis process. For the first time, we grouped such assays as early, intermediate, or advanced biomarkers which allow for the identification of the cells inthe initiation, promotion or aggressive stages of tumorigenesis. Our proposal, as a novelty, points out that using a battery containing assays from all three groups can identify if a certain agent/exposure can pose a carcinogenic risk; furthermore, it can gather mechanistic insights into the mode of the action of a specific carcinogen. This structured battery could be very useful for any type of in vitro study, containing human cell lines aiming to detect the potential carcinogenic risks of environmental agents/exposures. In fact, here, we include examples in which these approaches were successfully applied. Finally, we provide a series of advantages that, we believe, contribute to the suitability of our proposed approach for the evaluation of exposure-induced carcinogenic effects and for the development of an alternative strategy for conducting an exposure risk assessment. |
| publishDate |
2023 |
| dc.date.none.fl_str_mv |
2 2023-01-01 2023 2023-01-01 |
| dc.type.none.fl_str_mv |
Article http://purl.org/coar/resource_type/c_6501 VoR http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| dc.type.openaire.fl_str_mv |
info:eu-repo/semantics/article |
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article |
| dc.identifier.none.fl_str_mv |
https://ddd.uab.cat/record/274511 https://dx.doi.org/urn:doi:10.3390/ijms24097851 |
| url |
https://ddd.uab.cat/record/274511 https://dx.doi.org/urn:doi:10.3390/ijms24097851 |
| dc.language.none.fl_str_mv |
Inglés eng |
| language_invalid_str_mv |
Inglés |
| language |
eng |
| dc.relation.none.fl_str_mv |
European Commission https://doi.org/10.13039/501100000780 965196 Agencia Estatal de Investigación https://doi.org/10.13039/501100011033 PID2020-116789RB-C43 Agència de Gestió d'Ajuts Universitaris i de Recerca https://doi.org/10.13039/501100003030 2021/SGR-00731 |
| dc.rights.none.fl_str_mv |
open access http://purl.org/coar/access_right/c_abf2 https://creativecommons.org/licenses/by/4.0/ |
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info:eu-repo/semantics/openAccess |
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open access http://purl.org/coar/access_right/c_abf2 https://creativecommons.org/licenses/by/4.0/ |
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openAccess |
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application/pdf |
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