HBM4EU chromates study - Overall results and recommendations for the biomonitoring of occupational exposure to hexavalent chromium

Exposure to hexavalent chromium [Cr(VI)] may occur in several occupational activities, e.g., welding, Cr(VI) electroplating and other surface treatment processes. The aim of this study was to provide EU relevant data on occupational Cr(VI) exposure to support the regulatory risk assessment and decis...

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Autores: Santonen, Tiina, Porras, Simo P, Bocca, Beatrice, Bousoumah, Radia, Duca, Radu Corneliu, Galea, Karen S, Godderis, Lode, Göen, Thomas, Hardy, Emilie, Iavicoli, Ivo, Janasik, Beata, Jones, Kate, Leese, Elizabeth, Leso, Veruscka, Louro, Henriqueta, Majery, Nicole, Ndaw, Sophie, Pinhal, Hermínia, Ruggieri, Flavia, Silva, Maria J, van Nieuwenhuyse, An, Verdonck, Jelle, Viegas, Susana, Wasowicz, Wojciech, Sepai, Ovnair, Scheepers, Paul T J, Castaño, Argelia, Esteban-Lopez, Marta, HBM4EU chromates study team
Tipo de recurso: artículo
Fecha de publicación:2022
País:España
Institución:Instituto de Salud Carlos III (ISCIII)
Repositorio:Repisalud
Idioma:inglés
OAI Identifier:oai:repisalud.isciii.es:20.500.12105/14200
Acceso en línea:http://hdl.handle.net/20.500.12105/14200
Access Level:acceso abierto
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spelling HBM4EU chromates study - Overall results and recommendations for the biomonitoring of occupational exposure to hexavalent chromiumSantonen, TiinaPorras, Simo PBocca, BeatriceBousoumah, RadiaDuca, Radu CorneliuGalea, Karen SGodderis, LodeGöen, ThomasHardy, EmilieIavicoli, IvoJanasik, BeataJones, KateLeese, ElizabethLeso, VerusckaLouro, HenriquetaMajery, NicoleNdaw, SophiePinhal, HermíniaRuggieri, FlaviaSilva, Maria Jvan Nieuwenhuyse, AnVerdonck, JelleViegas, SusanaWasowicz, WojciechSepai, OvnairScheepers, Paul T JCastaño, ArgeliaEsteban-Lopez, MartaHBM4EU chromates study teamExposure to hexavalent chromium [Cr(VI)] may occur in several occupational activities, e.g., welding, Cr(VI) electroplating and other surface treatment processes. The aim of this study was to provide EU relevant data on occupational Cr(VI) exposure to support the regulatory risk assessment and decision-making. In addition, the capability and validity of different biomarkers for the assessment of Cr(VI) exposure were evaluated. The study involved nine European countries and involved 399 workers in different industry sectors with exposures to Cr(VI) such as welding, bath plating, applying or removing paint and other tasks. We also studied 203 controls to establish a background in workers with no direct exposure to Cr(VI). We applied a cross-sectional study design and used chromium in urine as the primary biomonitoring method for Cr(VI) exposure. Additionally, we studied the use of red blood cells (RBC) and exhaled breath condensate (EBC) for biomonitoring of exposure to Cr(VI). Personal measurements were used to study exposure to inhalable and respirable Cr(VI) by personal air sampling. Dermal exposure was studied by taking hand wipe samples. The highest internal exposures were observed in the use of Cr(VI) in electrolytic bath plating. In stainless steel welding the internal Cr exposure was clearly lower when compared to plating activities. We observed a high correlation between chromium urinary levels and air Cr(VI) or dermal total Cr exposure. Urinary chromium showed its value as a first approach for the assessment of total, internal exposure. Correlations between urinary chromium and Cr(VI) in EBC and Cr in RBC were low, probably due to differences in kinetics and indicating that these biomonitoring approaches may not be interchangeable but rather complementary. This study showed that occupational biomonitoring studies can be conducted successfully by multi-national collaboration and provide relevant information to support policy actions aiming to reduce occupational exposure to chemicals.ElsevierUnión Europea. Comisión Europea. H202020222022-04-2720222022-03-0120222022-03-01research articlehttp://purl.org/coar/resource_type/c_2df8fbb1VoRhttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articleapplication/pdfapplication/pdfhttp://hdl.handle.net/20.500.12105/14200reponame:Repisaludinstname:Instituto de Salud Carlos III (ISCIII)InglésengEuropean Commission http://dx.doi.org/10.13039/501100000780 Horizon 2020 Framework Programme 733032open accesshttp://purl.org/coar/access_right/c_abf2Atribución 4.0 Internacionalhttp://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:repisalud.isciii.es:20.500.12105/142002026-06-12T12:43:37Z
dc.title.none.fl_str_mv HBM4EU chromates study - Overall results and recommendations for the biomonitoring of occupational exposure to hexavalent chromium
title HBM4EU chromates study - Overall results and recommendations for the biomonitoring of occupational exposure to hexavalent chromium
spellingShingle HBM4EU chromates study - Overall results and recommendations for the biomonitoring of occupational exposure to hexavalent chromium
Santonen, Tiina
title_short HBM4EU chromates study - Overall results and recommendations for the biomonitoring of occupational exposure to hexavalent chromium
title_full HBM4EU chromates study - Overall results and recommendations for the biomonitoring of occupational exposure to hexavalent chromium
title_fullStr HBM4EU chromates study - Overall results and recommendations for the biomonitoring of occupational exposure to hexavalent chromium
title_full_unstemmed HBM4EU chromates study - Overall results and recommendations for the biomonitoring of occupational exposure to hexavalent chromium
title_sort HBM4EU chromates study - Overall results and recommendations for the biomonitoring of occupational exposure to hexavalent chromium
dc.creator.none.fl_str_mv Santonen, Tiina
Porras, Simo P
Bocca, Beatrice
Bousoumah, Radia
Duca, Radu Corneliu
Galea, Karen S
Godderis, Lode
Göen, Thomas
Hardy, Emilie
Iavicoli, Ivo
Janasik, Beata
Jones, Kate
Leese, Elizabeth
Leso, Veruscka
Louro, Henriqueta
Majery, Nicole
Ndaw, Sophie
Pinhal, Hermínia
Ruggieri, Flavia
Silva, Maria J
van Nieuwenhuyse, An
Verdonck, Jelle
Viegas, Susana
Wasowicz, Wojciech
Sepai, Ovnair
Scheepers, Paul T J
Castaño, Argelia
Esteban-Lopez, Marta
HBM4EU chromates study team
author Santonen, Tiina
author_facet Santonen, Tiina
Porras, Simo P
Bocca, Beatrice
Bousoumah, Radia
Duca, Radu Corneliu
Galea, Karen S
Godderis, Lode
Göen, Thomas
Hardy, Emilie
Iavicoli, Ivo
Janasik, Beata
Jones, Kate
Leese, Elizabeth
Leso, Veruscka
Louro, Henriqueta
Majery, Nicole
Ndaw, Sophie
Pinhal, Hermínia
Ruggieri, Flavia
Silva, Maria J
van Nieuwenhuyse, An
Verdonck, Jelle
Viegas, Susana
Wasowicz, Wojciech
Sepai, Ovnair
Scheepers, Paul T J
Castaño, Argelia
Esteban-Lopez, Marta
HBM4EU chromates study team
author_role author
author2 Porras, Simo P
Bocca, Beatrice
Bousoumah, Radia
Duca, Radu Corneliu
Galea, Karen S
Godderis, Lode
Göen, Thomas
Hardy, Emilie
Iavicoli, Ivo
Janasik, Beata
Jones, Kate
Leese, Elizabeth
Leso, Veruscka
Louro, Henriqueta
Majery, Nicole
Ndaw, Sophie
Pinhal, Hermínia
Ruggieri, Flavia
Silva, Maria J
van Nieuwenhuyse, An
Verdonck, Jelle
Viegas, Susana
Wasowicz, Wojciech
Sepai, Ovnair
Scheepers, Paul T J
Castaño, Argelia
Esteban-Lopez, Marta
HBM4EU chromates study team
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Unión Europea. Comisión Europea. H2020
description Exposure to hexavalent chromium [Cr(VI)] may occur in several occupational activities, e.g., welding, Cr(VI) electroplating and other surface treatment processes. The aim of this study was to provide EU relevant data on occupational Cr(VI) exposure to support the regulatory risk assessment and decision-making. In addition, the capability and validity of different biomarkers for the assessment of Cr(VI) exposure were evaluated. The study involved nine European countries and involved 399 workers in different industry sectors with exposures to Cr(VI) such as welding, bath plating, applying or removing paint and other tasks. We also studied 203 controls to establish a background in workers with no direct exposure to Cr(VI). We applied a cross-sectional study design and used chromium in urine as the primary biomonitoring method for Cr(VI) exposure. Additionally, we studied the use of red blood cells (RBC) and exhaled breath condensate (EBC) for biomonitoring of exposure to Cr(VI). Personal measurements were used to study exposure to inhalable and respirable Cr(VI) by personal air sampling. Dermal exposure was studied by taking hand wipe samples. The highest internal exposures were observed in the use of Cr(VI) in electrolytic bath plating. In stainless steel welding the internal Cr exposure was clearly lower when compared to plating activities. We observed a high correlation between chromium urinary levels and air Cr(VI) or dermal total Cr exposure. Urinary chromium showed its value as a first approach for the assessment of total, internal exposure. Correlations between urinary chromium and Cr(VI) in EBC and Cr in RBC were low, probably due to differences in kinetics and indicating that these biomonitoring approaches may not be interchangeable but rather complementary. This study showed that occupational biomonitoring studies can be conducted successfully by multi-national collaboration and provide relevant information to support policy actions aiming to reduce occupational exposure to chemicals.
publishDate 2022
dc.date.none.fl_str_mv 2022
2022-04-27
2022
2022-03-01
2022
2022-03-01
dc.type.none.fl_str_mv research article
http://purl.org/coar/resource_type/c_2df8fbb1
VoR
http://purl.org/coar/version/c_970fb48d4fbd8a85
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv http://hdl.handle.net/20.500.12105/14200
url http://hdl.handle.net/20.500.12105/14200
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.relation.none.fl_str_mv European Commission http://dx.doi.org/10.13039/501100000780 Horizon 2020 Framework Programme 733032
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
Atribución 4.0 Internacional
http://creativecommons.org/licenses/by/4.0/
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
Atribución 4.0 Internacional
http://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:Repisalud
instname:Instituto de Salud Carlos III (ISCIII)
instname_str Instituto de Salud Carlos III (ISCIII)
reponame_str Repisalud
collection Repisalud
repository.name.fl_str_mv
repository.mail.fl_str_mv
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