Delivery of a sebum modulator by an engineered skin microbe in mice

Microorganisms can be equipped with synthetic genetic programs for the production of targeted therapeutic molecules. Cutibacterium acnes is the most abundant commensal of the human skin, making it an attractive chassis to create skin-delivered therapeutics. Here, we report the engineering of this ba...

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Detalles Bibliográficos
Autores: Knödlseder, Nastassia, Fábrega, María José, Santos Moreno, Javier, Manils, Joan, Toloza, Lorena, Marín Vilar, Maria, Fernández Avilés, Cristina, Broadbent, Katrina, Maruotti, Julien, Lemenager, Hélène, Carolis, Carlo, Zouboulis, Christos C., Soler Prat, Concepció, Lood, Rolf, Brüggemann, Holger, Güell Cargol, Marc, 1982-
Tipo de recurso: artículo
Estado:Versión aceptada para publicación
Fecha de publicación:2024
País:España
Institución:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Repositorio:Recercat. Dipósit de la Recerca de Catalunya
OAI Identifier:oai:recercat.cat:10230/60285
Acceso en línea:http://hdl.handle.net/10230/60285
http://dx.doi.org/10.1038/s41587-023-02072-4
Access Level:acceso abierto
Palabra clave:Applied microbiology
Genetic engineering
Descripción
Sumario:Microorganisms can be equipped with synthetic genetic programs for the production of targeted therapeutic molecules. Cutibacterium acnes is the most abundant commensal of the human skin, making it an attractive chassis to create skin-delivered therapeutics. Here, we report the engineering of this bacterium to produce and secrete the therapeutic molecule neutrophil gelatinase-associated lipocalin, in vivo, for the modulation of cutaneous sebum production.

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